產(chǎn)品中心Cell Resources
聯(lián)系我們CONTACT US
400-999-210024小時服務(wù)熱線
產(chǎn)品概述
| 名稱 | HCC1937 (人乳腺癌細(xì)胞) (STR鑒定正確) |
| 別稱 | HCC-1937 |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | HCC1937細(xì)胞1995年10月13日最初來源于原發(fā)性導(dǎo)管癌，用了11.5個月建株。腫瘤分類為TNMⅡB期，3級。BRCA1分析表明，HCC1937細(xì)胞是BRCA 15382C突變純合的，而來源于同一病人的類淋巴母細(xì)胞細(xì)胞株在這個突變位點上是雜合的。另兩個家庭成員也有這個突變；一個同卵雙生姐妹也患有乳腺癌。HCC1937細(xì)胞有一個后天的Tp53突變，而其野生型等位基因丟失；一個PTEN基因的后天的純合缺失，以及多個與乳腺癌發(fā)病機理相關(guān)的位點上發(fā)生的雜合突變。HCC1937細(xì)胞Her2-neu和p53表達(dá)都呈陰性。HCC1937細(xì)胞的上皮細(xì)胞特異性標(biāo)志上皮細(xì)胞糖蛋2(EGP2)和細(xì)胞角蛋白19都呈陽性；雌激素受體(ER)和孕酮(PR)表達(dá)陰性。 |
| 年齡（性別） | 女性；23歲 |
| 組織來源 | 乳房；原發(fā)性導(dǎo)管癌；3級，ⅡB期 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 乳腺癌細(xì)胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~50-60 hours |
| 受體表達(dá)情況 | estrogen receptor, negative;progesterone receptor, negative |
| 基因表達(dá)情況 | Epithelial glycoprotein 2 (EGP2); cytokeratin 19 |
| 保藏機構(gòu) | ATCC; CRL-2336 DSMZ; ACC-513 |
STR鑒定
-
STR位點信息
Amelogenin X CSF1PO 12 D2S1338 25 D3S1358 18 D5S818 12 D7S820 9,10 D8S1179 12,13 D13S317 13 D16S539 13,14 D18S51 12 D19S433 14,15 D21S11 28 FGA 20,22 PentaD 9 PentaE 13 TH01 6 TPOX 11 vWA 16,17 D6S1043 11 D12S391 17.3,21 D2S441 10 -
STR鑒定圖
-
參考文獻(xiàn)
-
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine (2025-02-10)
期刊：EMBO REPORTS
DOI：10.1038/s44319-025-00385-w
影響因子 ：6.5
引用產(chǎn)品： 293FT 細(xì)胞 , JeKo-1 細(xì)胞 , Jurkat, Clone E6-1 細(xì)胞 , T-47D 細(xì)胞 , BT-549 細(xì)胞 , HCC1937 細(xì)胞 , SK-BR-3 [SKBR3] 細(xì)胞 , ZR-75-1 細(xì)胞 , BT-474 [BT474] 細(xì)胞 , MDA-MB-436 細(xì)胞 , RPMI-1640 培養(yǎng)基 , McCoy's 5A 培養(yǎng)基 , DMEM高糖 培養(yǎng)基
-
CDKN3 as a key regulator of G2M phase in triple-negative breast cancer: Insights from multi-transcriptomic analysis (2025-01-26)
期刊：IUBMB LIFE
DOI：10.1002/iub.2922
影響因子 ：3.7
引用產(chǎn)品： MCF 10A 細(xì)胞 , MDA-MB-231 細(xì)胞 , T-47D 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , HCC1937 細(xì)胞 , 特級胎牛血清
-
Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets (2024-10-17)
期刊：Advanced Science
影響因子 ：14.3
引用產(chǎn)品： HCC1937 細(xì)胞 , MCF 10A細(xì)胞專用培養(yǎng)基
-
Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-α signaling axis in triple-negative breast cancer (2024-01-24)
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2024.216642
影響因子 ：9.7
引用產(chǎn)品： MDA-MB-231 細(xì)胞 , HCC1937 細(xì)胞
-
Vertical pathway inhibition of receptor tyrosine kinases and BAD with synergistic efficacy in triple negative breast cancer (2024-01-10)
期刊：npj Precision Oncology
DOI：10.1038/s41698-023-00489-3
影響因子 ：7.9
引用產(chǎn)品： MDA-MB-231/GFP 細(xì)胞 , BT-549 細(xì)胞 , HCC1937 細(xì)胞 , Hs 578T 細(xì)胞
-
Tanshinone I improves TNBC chemosensitivity by suppressing late-phase autophagy through AKT/p38 MAPK signaling pathway (2024-07-02)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2024.117037
影響因子 ：6.9
引用產(chǎn)品： HCC1937 細(xì)胞 , HCC1954 細(xì)胞 , 重組人胰島素溶液（10 mg/mL）
-
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids (2024-10-18)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.156155
影響因子 ：6.7
引用產(chǎn)品： MDA-MB-231 細(xì)胞 , HCC1937 細(xì)胞
-
Antiplatelet drug ticagrelor suppresses triple negative breast cancer metastasis by targeting PI3K (2024-07-03)
期刊：BIOCHEMICAL PHARMACOLOGY
影響因子 ：5.3
引用產(chǎn)品： 特級胎牛血清 , MDA-MB-157 細(xì)胞 , SUM159PT 細(xì)胞 , MDA-MB-435 細(xì)胞 , HCC1937 細(xì)胞 , MDA-MB-468-06 細(xì)胞 , MDA-MB-231 細(xì)胞
-
Triple-Negative Breast Cancer Intrinsic FTSJ1 Favors Tumor Progression and Attenuates CD8+ T Cell Infiltration (2024-01-31)
期刊：Cancers
影響因子 ：5.2
引用產(chǎn)品： MDA-MB-231 細(xì)胞 , HCC1937 細(xì)胞 , 4T1 細(xì)胞 , 特級胎牛血清 , DMEM高糖 培養(yǎng)基 , RPMI-1640 培養(yǎng)基
-
Constructing a novel prognostic model for triple-negative breast cancer based on genes associated with vasculogenic mimicry (2024-05-08)
期刊：Aging-US
影響因子 ：5.2
引用產(chǎn)品： BT-549 細(xì)胞 , MDA-MB-231 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , HCC1937 細(xì)胞 , Hs 578T 細(xì)胞 , MCF 10A 細(xì)胞 , BT-474 [BT474] 細(xì)胞 , SK-BR-3 [SKBR3] 細(xì)胞
-
Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors (2024-04-04)
期刊：Chinese Journal of Cancer Research
DOI：10.21147/j.issn.1000-9604.2024.02.03
影響因子 ：5.1
引用產(chǎn)品： HCC1937 細(xì)胞
-
PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell (2024-08-12)
期刊：Biomolecules
影響因子 ：4.8
引用產(chǎn)品： 4T1 細(xì)胞 , BT-549 細(xì)胞 , HCC1937 細(xì)胞
-
The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation (2024-01-22)
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影響因子 ：4.8
引用產(chǎn)品： MCF 10A 細(xì)胞 , HCC1806 細(xì)胞 , HCC1937 細(xì)胞 , MDA-MB-468 細(xì)胞 , BT-20 細(xì)胞 , Hs 578T 細(xì)胞 , MDA-MB-436 細(xì)胞 , MCF 10A細(xì)胞專用培養(yǎng)基 , HCC1806細(xì)胞專用培養(yǎng)基 , HCC1937細(xì)胞專用培養(yǎng)基 , MDA-MB-468細(xì)胞專用培養(yǎng)基 (L15) , BT-20細(xì)胞專用培養(yǎng)基 , Hs 578T細(xì)胞專用培養(yǎng)基 , MDA-MB-436細(xì)胞專用培養(yǎng)基 (L15)
-
Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines (2024-03-21)
期刊：MOLECULES
影響因子 ：4.6
引用產(chǎn)品： HCT-15 細(xì)胞 , HCC1937 細(xì)胞 , MDA-MB-231 細(xì)胞 , HL-7702 [L-02; LO2] 細(xì)胞 , NCM460 細(xì)胞
-
GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3 (2024-11-02)
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2024.2420383
影響因子 ：4.4
引用產(chǎn)品： SK-BR-3 [SKBR3] 細(xì)胞 , MDA-MB-468-06 細(xì)胞 , MCF 10A 細(xì)胞 , MDA-MB-231 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , HCC1937 細(xì)胞
-
CAPRIN1 Transcriptionally Activated PLPP4 to Inhibit DOX Sensitivity and Promote Breast Cancer Progression (2024-11-18)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01614-0
影響因子 ：1.8
引用產(chǎn)品： DMEM/F12 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , RPMI-1640 培養(yǎng)基 , 293T [HEK-293T] 細(xì)胞 , HCC1937 細(xì)胞 , Leibovitz's L-15 培養(yǎng)基 , MDA-MB-231 細(xì)胞 , MCF 10A 細(xì)胞 , 馬血清 , 特級胎牛血清
-
Oxypalmatine regulates proliferation and apoptosis of breast cancer cells by inhibiting PI3K/AKT signaling and its efficacy against breast cancer organoids (2023-03-10)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154752
影響因子 ：7.9
引用產(chǎn)品： MCF7 [MCF-7] 細(xì)胞 , HCC1937 細(xì)胞 , DU4475 細(xì)胞 , MDA-MB-231 細(xì)胞
-
Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis (2023-06-09)
期刊：AMERICAN JOURNAL OF PATHOLOGY
DOI：10.1016/j.ajpath.2023.05.010
影響因子 ：6.0
引用產(chǎn)品： HCC1937 細(xì)胞 , MDA-MB-231 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
-
Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer (2023-10-27)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.6
引用產(chǎn)品： HCC1937 細(xì)胞 , NCI-H520 細(xì)胞 , SNU-387 細(xì)胞 , SNU-182 細(xì)胞 , BEAS-2B 細(xì)胞 , MCF 10A細(xì)胞專用培養(yǎng)基
-
Leveraging senescence-oxidative stress co-relation to predict prognosis and drug sensitivity in breast invasive carcinoma (2023-08-04)
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2023.1179050
影響因子 ：5.2
引用產(chǎn)品： MCF7 [MCF-7] 細(xì)胞 , BT-20 細(xì)胞 , MDA-MB-231 細(xì)胞 , HCC1806 細(xì)胞 , HCC1937 細(xì)胞 , MCF7 [MCF-7]細(xì)胞專用培養(yǎng)基 , BT-20細(xì)胞專用培養(yǎng)基 , MDA-MB-231細(xì)胞專用培養(yǎng)基 (L15) , HCC1806細(xì)胞專用培養(yǎng)基 , HCC1937細(xì)胞專用培養(yǎng)基
-
Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells (2023-12-08)
期刊：Scientific Reports
DOI：10.1038/s41598-023-49136-8
影響因子 ：4.6
引用產(chǎn)品： MDA-MB-231 細(xì)胞 , HCC1937 細(xì)胞 , MDA-MB-468 細(xì)胞 , BT-20 細(xì)胞 , Hs 578T 細(xì)胞 , MCF 10A 細(xì)胞
-
Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis (2023-02-06)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116415
影響因子 ：3.8
引用產(chǎn)品： MDA-MB-231 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , MDA-MB-468 細(xì)胞 , HCC1937 細(xì)胞 , MDA-MB-453 細(xì)胞 , 4T1 細(xì)胞 , MCF 10A 細(xì)胞 , Annexin V-FITC/ PI熒光雙染細(xì)胞凋亡檢測試劑盒
-
Prognosis stratification of patients with breast invasive carcinoma based on cysteine metabolism-disulfidptosis affinity (2023-07-08)
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-05028-y
影響因子 ：3.6
引用產(chǎn)品： MCF7 [MCF-7] 細(xì)胞 , MCF7 [MCF-7]細(xì)胞專用培養(yǎng)基 , BT-20 細(xì)胞 , BT-20細(xì)胞專用培養(yǎng)基 , MDA-MB-231 細(xì)胞 , MDA-MB-231細(xì)胞專用培養(yǎng)基 (L15) , MDA-kb2 細(xì)胞 , MDA-kb2細(xì)胞專用培養(yǎng)基 (L15) , HCC1937 細(xì)胞 , HCC1937細(xì)胞專用培養(yǎng)基
-
LINC01140 Hinders the Development of Breast Cancer Through Targeting miR-200b-3p to Downregulate DMD (2023-11-27)
期刊：CELL TRANSPLANTATION
影響因子 ：3.3
引用產(chǎn)品： DMEM/F12 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , RPMI-1640 培養(yǎng)基 , 馬血清 , 特級胎牛血清 , MCF 10A 細(xì)胞 , HCC1937 細(xì)胞 , MDA-MB-231 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞
-
Scoparone inhibits breast cancer cell viability through the NF?κB signaling pathway (2023-05-17)
期刊：Experimental and Therapeutic Medicine
影響因子 ：2.7
引用產(chǎn)品： MCF 10A 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , MDA-MB-231 細(xì)胞 , ZR-75-1 細(xì)胞 , HCC1937 細(xì)胞 , 293 [HEK-293] 細(xì)胞
-
RAMP2-AS1 inhibits CXCL11 expression to suppress malignant phenotype of breast cancer by recruiting DNMT1 and DNMT3B (2022-04-04)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113139
影響因子 ：3.7
引用產(chǎn)品： HCC1937 細(xì)胞 , MDA-MB-231 細(xì)胞 , MDA-MB-453 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , MCF 10A 細(xì)胞
-
LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability (2021-11-05)
期刊：Aging-US
影響因子 ：5.2
引用產(chǎn)品： MDA-MB-231 細(xì)胞 , HCC1937 細(xì)胞
-
Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint (2021-11-08)
期刊：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI：10.1016/j.bbamcr.2021.119169
影響因子 ：5.1
引用產(chǎn)品： HCC1937 細(xì)胞
-
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion (2020-07-07)
期刊：Cell Reports
DOI：10.1016/j.celrep.2020.107879
影響因子 ：8.1
引用產(chǎn)品： HCC1937 細(xì)胞 , BT-549 細(xì)胞 , BEAS-2B 細(xì)胞 , 人胰腺星狀細(xì)胞
-
Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway (2020-10-30)
期刊：Frontiers in Oncology
影響因子 ：4.7
引用產(chǎn)品： HCC1937 細(xì)胞
FAQs
Q：{{item.question}}
A：
產(chǎn)品資料
識別碼示意圖
