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MRC-5 (人胚肺細(xì)胞) (STR鑒定正確)
貨號(hào)：CL-0161
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價(jià)格： ￥1600
生長(zhǎng)培養(yǎng)基：MEM（含NEAA）＋10% FBS＋1% P/S
產(chǎn)品概述
| 名稱(chēng) | MRC-5 (人胚肺細(xì)胞) (STR鑒定正確) |
| 別稱(chēng) | MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 |
| 種屬 | 人 |
| 生長(zhǎng)特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 成纖維細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長(zhǎng)培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項(xiàng) | 該細(xì)胞為有限傳代細(xì)胞系，傳代次數(shù)過(guò)高會(huì)導(dǎo)致細(xì)胞生長(zhǎng)特性發(fā)生變化，建議到貨3代內(nèi)完成實(shí)驗(yàn)。 |
| 年齡（性別） | 男性；14周齡 |
| 組織來(lái)源 | 肺 |
| 細(xì)胞類(lèi)型 | 有限細(xì)胞系 |
| 生物安全等級(jí) | BSL-1 |
| 保藏機(jī)構(gòu) | ATCC; CCL-171 ECACC; 97112601 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X,Y CSF1PO 11,12 D2S1338 20 D3S1358 15,17 D5S818 11,12 D7S820 10,11 D8S1179 13 D13S317 11,14 D16S539 9,11 D18S51 15,21 D19S433 14,15 D21S11 31.2 FGA 21,23 PentaD 12 PentaE 12,16 TH01 8 TPOX 8 vWA 15 D6S1043 11,19 D12S391 20,22 D2S441 10,11 -
STR鑒定圖
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參考文獻(xiàn)
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Biomimetic Topological Micropattern Arrays Regulate the Heterogeneity of Cellular Fates in Lung Fibroblasts between Fibrosis and Invasion (2025-01-01)
期刊：ACS Nano
影響因子 ：15.8
引用產(chǎn)品： MRC-5 細(xì)胞
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A microfluidic co-culture platform for lung cancer cells electrotaxis study under the existence of stromal cells (2025-02-03)
期刊：BIOELECTROCHEMISTRY
DOI：10.1016/j.bioelechem.2025.108917
影響因子 ：4.8
引用產(chǎn)品： MRC-5 細(xì)胞 , 特級(jí)胎牛血清
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Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease (2025-01-22)
期刊：RESPIRATORY RESEARCH
DOI：10.1186/s12931-025-03111-1
影響因子 ：4.7
引用產(chǎn)品： HL-60 細(xì)胞 , MRC-5 細(xì)胞
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Cancer-Derived Extracellular Vesicle ITGB2 Promotes the Progression of Triple-Negative Breast Cancer via the Activation of Cancer-Associated Fibroblasts (2025-01-23)
期刊：GLOBAL CHALLENGES
影響因子 ：4.4
引用產(chǎn)品： MRC-5 細(xì)胞
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Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation (2024-04-22)
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2024.04.013
影響因子 ：14.5
引用產(chǎn)品： MRC-5 細(xì)胞 , Hela 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基
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Fatty Acid Oxidation-Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica-Induced Pulmonary Fibrosis (2024-12-25)
期刊：Advanced Science
影響因子 ：14.3
引用產(chǎn)品： MRC-5 細(xì)胞
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Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase (2024-08-28)
期刊：ACS Central Science
DOI：10.1021/acscentsci.4c00798
影響因子 ：12.7
引用產(chǎn)品： MRC-5 細(xì)胞 , NIH/3T3 細(xì)胞
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Telomerase-Responsive CRISPR System-Regulated Nanobomb for Triggering Research on Telomerase “Self-Detonation” (2024-12-16)
期刊：ACS Applied Materials & Interfaces
影響因子 ：8.3
引用產(chǎn)品： MCF7 [MCF-7] 細(xì)胞 , MDA-MB-231 細(xì)胞 , Hela 細(xì)胞 , MRC-5 細(xì)胞
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Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy (2024-01-06)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c01889
影響因子 ：7.3
引用產(chǎn)品： A549 [A-549] 細(xì)胞 , A549/DDP 細(xì)胞 , A549/Tax 細(xì)胞 , A-431 細(xì)胞 , MRC-5 細(xì)胞
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Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket (2024-11-15)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.4c01533
影響因子 ：6.8
引用產(chǎn)品： MRC-5 細(xì)胞
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Bruceine A inhibits TGF-β1/Smad pathway in pulmonary fibrosis by blocking gal3/TGF-β1 interaction (2024-11-21)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.156267
影響因子 ：6.7
引用產(chǎn)品： HFL1 細(xì)胞 , MRC-5 細(xì)胞
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SULF1 expression is increased and promotes fibrosis through the TGF-β1/SMAD pathway in idiopathic pulmonary fibrosis (2024-10-01)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-05698-3
影響因子 ：6.1
引用產(chǎn)品： MRC-5 細(xì)胞 , HFL1 細(xì)胞
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Identification of idiopathic pulmonary fibrosis hub genes and exploration of the mechanisms of action of Jinshui Huanxian formula (2024-04-08)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112048
影響因子 ：5.6
引用產(chǎn)品： MRC-5 細(xì)胞
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Anti-carbamylated protein antibodies drive AEC II toward a profibrotic phenotype by interacting with carbamylated TLR5 (2024-02-16)
期刊：RHEUMATOLOGY
DOI：10.1093/rheumatology/keae111
影響因子 ：5.5
引用產(chǎn)品： MRC-5 細(xì)胞 , IMR-90 細(xì)胞 , A549 [A-549] 細(xì)胞 , BEAS-2B 細(xì)胞
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Inhalable Carbonyl Sulfide Donor-Hybridized Selective Phosphodiesterase 10A Inhibitor for Treating Idiopathic Pulmonary Fibrosis by Inhibiting Tumor Growth Factor-β Signaling and Activating the cAMP/Protein Kinase A/cAMP Response Element-Binding Protein (CREB)/p53 Axis (2024-12-28)
期刊：ACS Pharmacology & Translational Science
影響因子 ：4.9
引用產(chǎn)品： MRC-5 細(xì)胞
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Turmeric pomace-derived polysaccharides: Extraction, structural insights, and anti-aging potential (2024-12-16)
期刊：Food Bioscience
DOI：10.1016/j.fbio.2024.105717
影響因子 ：4.8
引用產(chǎn)品： MRC-5 細(xì)胞 , MEM 培養(yǎng)基
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Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway (2024-06-25)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112542
影響因子 ：4.8
引用產(chǎn)品： MRC-5 細(xì)胞
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Exploring ABHD5 as a Lipid-Related Biomarker in Idiopathic Pulmonary Fibrosis: Integrating Machine Learning, Bioinformatics, and In Vitro Experiments (2024-07-24)
期刊：INFLAMMATION
DOI：10.1007/s10753-024-02107-1
影響因子 ：4.5
引用產(chǎn)品： MRC-5 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基 , 青霉素-鏈霉素溶液（雙抗），100×
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High expression of SLC7A1 in high-grade serous ovarian cancer promotes tumor progression and is involved in MAPK/ERK pathway and EMT (2024-05-16)
期刊：Cancer Medicine
影響因子 ：4.0
引用產(chǎn)品： TGFB1/TGFβ1/TGF-β1, Human, Recombinant , MRC-5 細(xì)胞
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Cevanine-type alkaloids from the bulbs of Fritillaria unibracteata var. wabuensis and their antifibrotic activities in vitro (2024-02-10)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2024.114018
影響因子 ：3.8
引用產(chǎn)品： MRC-5 細(xì)胞 , MEM 培養(yǎng)基
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Discovery of Oxidized p-Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi (2024-06-29)
期刊：JOURNAL OF NATURAL PRODUCTS
DOI：10.1021/acs.jnatprod.4c00422
影響因子 ：3.3
引用產(chǎn)品： RAW 264.7 細(xì)胞 , MRC-5 細(xì)胞
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Integrative Analysis and Validation of a Cancer-associated Fibroblasts Senescence-related Signature for Risk Stratification and Therapeutic Prediction in Esophageal Squamous Cell Carcinoma (2024-09-09)
期刊：Journal of Cancer
影響因子 ：3.3
引用產(chǎn)品： MRC-5 細(xì)胞
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Improvement of idiopathic pulmonary fibrosis through a combination of Astragalus radix and Angelica sinensis radix via mammalian target of rapamycin signaling pathway-induced autophagy in rat (2024-02-27)
期刊：Journal of Thoracic Disease
影響因子 ：2.1
引用產(chǎn)品： MRC-5 細(xì)胞
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Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma (2024-01-30)
期刊：JOURNAL OF CHEMOTHERAPY
DOI：10.1080/1120009X.2024.2308975
影響因子 ：1.9
引用產(chǎn)品： LLC [LL/2; LLC1] 細(xì)胞 , CMT64 細(xì)胞 , A549 [A-549] 細(xì)胞 , NCI-H1299 細(xì)胞 , WI-38 細(xì)胞 , MRC-5 細(xì)胞
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SMURF1-Interference Effects Autophagy and Pulmonary Fibrosis through SMAD7 and the TGF-β1/SMAD Pathway (2024-05-02)
期刊：MOLECULAR BIOLOGY
影響因子 ：1.2
引用產(chǎn)品： MRC-5 細(xì)胞
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Intelligent Dual-Lock Deoxyribonucleic Acid Automatons Boosting Precise Tumor Imaging (2023-01-10)
期刊：ACS Applied Materials & Interfaces
影響因子 ：9.5
引用產(chǎn)品： A549 [A-549] 細(xì)胞 , MRC-5 細(xì)胞
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Interleukin-18-primed human umbilical cord-mesenchymal stem cells achieve superior therapeutic efficacy for severe viral pneumonia via enhancing T-cell immunosuppression (2023-01-28)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05597-3
影響因子 ：9.0
引用產(chǎn)品： MRC-5 細(xì)胞 , 小鼠Ⅱ型肺泡上皮細(xì)胞
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CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function (2023-12-18)
期刊：CELLULAR & MOLECULAR BIOLOGY LETTERS
DOI：10.1186/s11658-023-00518-w
影響因子 ：8.3
引用產(chǎn)品： MRC-5 細(xì)胞
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Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma (2023-01-12)
期刊：International Journal of Nanomedicine
影響因子 ：8.0
引用產(chǎn)品： AML12 細(xì)胞 , MRC-5 細(xì)胞 , 293T [HEK-293T] 細(xì)胞 , RAW 264.7 細(xì)胞 , Hep G2 細(xì)胞
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Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis (2023-04-14)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1159856
影響因子 ：7.3
引用產(chǎn)品： MRC-5 細(xì)胞 , MEM 培養(yǎng)基
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A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis (2023-11-14)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1268141
影響因子 ：7.3
引用產(chǎn)品： MRC-5 細(xì)胞
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Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly (2023-12-17)
期刊：RESPIRATORY RESEARCH
DOI：10.1186/s12931-023-02633-w
影響因子 ：5.8
引用產(chǎn)品： MRC-5 細(xì)胞
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CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF-β/Smad signaling (2023-03-02)
期刊：BIOCHEMICAL PHARMACOLOGY
影響因子 ：5.8
引用產(chǎn)品： MRC-5 細(xì)胞
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Study of the antiaging effects of bird's nest peptide based on biochemical, cellular, and animal models (2023-03-05)
期刊：Journal of Functional Foods
影響因子 ：5.6
引用產(chǎn)品： Hacat 細(xì)胞 , B16 細(xì)胞 , MRC-5 細(xì)胞
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Co-treatment of nicotinamide mononucleotide and neoagarooligosaccharide mitigates aging-induced cognitive impairment by promoting mitochondrial dynamics (2023-11-29)
期刊：Journal of Functional Foods
影響因子 ：5.6
引用產(chǎn)品： MRC-5 細(xì)胞
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YuPingFeng (YPF) upregulates caveolin-1 (CAV1) to alleviate pulmonary fibrosis through the TGF-β1/Smad2 pathway (2023-10-28)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：5.4
引用產(chǎn)品： MRC-5 細(xì)胞
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Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients (2023-06-10)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：5.4
引用產(chǎn)品： MRC-5 細(xì)胞
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Construction of a TFs-miRNA-mRNA network related to idiopathic pulmonary fibrosis (2023-01-31)
期刊：Annals of Translational Medicine
影響因子 ：3.6
引用產(chǎn)品： MRC-5 細(xì)胞
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Integrated bioinformatics analysis for the identification of idiopathic pulmonary fibrosis–related genes and potential therapeutic drugs (2023-10-04)
期刊：BMC Pulmonary Medicine
DOI：10.1186/s12890-023-02678-z
影響因子 ：3.1
引用產(chǎn)品： 人胚肺成纖維細(xì)胞 , MRC-5 細(xì)胞 , MEM 培養(yǎng)基
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Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p (2023-10-02)
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影響因子 ：2.9
引用產(chǎn)品： MRC-5 細(xì)胞 , MEM 培養(yǎng)基 , 特級(jí)胎牛血清 , MEM非必需氨基酸溶液 (NEAA)，100× , 青霉素-鏈霉素溶液 (雙抗)，100×
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Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma (2023-02-24)
期刊：Thoracic Cancer
影響因子 ：2.9
引用產(chǎn)品： MRC-5 細(xì)胞 , MRC-5細(xì)胞專(zhuān)用培養(yǎng)基 , NCI-H1299 細(xì)胞 , NCI-H1975 細(xì)胞 , A549 [A-549] 細(xì)胞 , NCI-H1650 細(xì)胞 , PC-9 細(xì)胞
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Krüppel-like factor 15 counteracts endoplasmic reticulum stress and suppresses lung fibroblast proliferation and extracellular matrix accumulation (2023-07-26)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2023.102183
影響因子 ：2.6
引用產(chǎn)品： MRC-5 細(xì)胞
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CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis (2022-11-25)
期刊：Signal Transduction and Targeted Therapy
DOI：10.1038/s41392-022-01230-5
影響因子 ：38.1
引用產(chǎn)品： MRC-5 細(xì)胞
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Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model (2022-10-18)
期刊：Redox Biology
DOI：10.1016/j.redox.2022.102509
影響因子 ：10.8
引用產(chǎn)品： MRC-5 細(xì)胞
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Rational engineering of adeno-associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity (2022-09-22)
期刊：CELL PROLIFERATION
影響因子 ：8.8
引用產(chǎn)品： 293T [HEK-293T] 細(xì)胞 , HuH-7 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , MRC-5 細(xì)胞 , Hepa 1-6 細(xì)胞 , Renca [RenCa] 細(xì)胞
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Exosome-transmitted S100A4 induces immunosuppression and non-small cell lung cancer development by activating STAT3 (2022-11-12)
期刊：CLINICAL AND EXPERIMENTAL IMMUNOLOGY
影響因子 ：5.7
引用產(chǎn)品： MRC-5 細(xì)胞 , A549 [A-549] 細(xì)胞 , NCI-H358 細(xì)胞 , NCI-H1299 細(xì)胞 , NCI-H460 [H460] 細(xì)胞
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Circular RNA circESPL1 knockdown alleviates lipopolysaccharide (LPS)-induced lung cell injury via sponging miR-326 to regulate MAPK14 (2022-08-26)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109146
影響因子 ：5.7
引用產(chǎn)品： WI-38 細(xì)胞 , MRC-5 細(xì)胞 , WI-38細(xì)胞專(zhuān)用培養(yǎng)基 , MRC-5細(xì)胞專(zhuān)用培養(yǎng)基
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Circ_0044411 silencing protects infantile pneumonia from lipopolysaccharide-induced cell injury by sponging miR-141-3p to inhibit CCL16 expression (2022-12-19)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109425
影響因子 ：5.7
引用產(chǎn)品： MRC-5 細(xì)胞
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Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild Lignosus rhinocerotis (2022-09-17)
期刊：Biomed Research International
影響因子 ：3.2
引用產(chǎn)品： MRC-5 細(xì)胞
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Hsa_circ_0092887 targeting miR-490-5p/UBE2T promotes paclitaxel resistance in non-small cell lung cancer (2022-12-22)
期刊：JOURNAL OF CLINICAL LABORATORY ANALYSIS
影響因子 ：3.1
引用產(chǎn)品： MRC-5 細(xì)胞 , DMEM高糖 培養(yǎng)基 , 特級(jí)胎牛血清 , NCI-H1299 細(xì)胞 , A549 [A-549] 細(xì)胞 , Ham's F-12K 培養(yǎng)基 , RPMI-1640 培養(yǎng)基
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Hsa_circ_0079530/AQP4 Axis Is Related to Non-Small Cell Lung Cancer Development and Radiosensitivity (2022-10-20)
期刊：Annals of Thoracic and Cardiovascular Surgery
影響因子 ：1.9
引用產(chǎn)品： NCI-H2170 細(xì)胞 , A549 [A-549] 細(xì)胞 , MRC-5 細(xì)胞
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1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway (2021-11-07)
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2021.108339
影響因子 ：5.6
引用產(chǎn)品： MRC-5 細(xì)胞 , HELF 細(xì)胞
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Deubiquitylation and stabilization of Acf7 by ubiquitin carboxyl-terminal hydrolase 14 (USP14) is critical for NSCLC migration (2021-02-13)
期刊：JOURNAL OF BIOSCIENCES
DOI：10.1007/s12038-021-00140-y
影響因子 ：1.8
引用產(chǎn)品： A549 [A-549] 細(xì)胞 , 95-D [PLA-801D] 細(xì)胞 , NCI-H1299 細(xì)胞 , MRC-5 細(xì)胞
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Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis, and inflammatory response by miR-195-5p/TLR4 axis through NF-κB pathway in MRC-5 cells (2021-03-22)
期刊：Bioscience Biotechnology and Biochemistry
影響因子 ：1.6
引用產(chǎn)品： MRC-5 細(xì)胞
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Retracted: Circular RNA ANKRD36 attends to lipopolysaccharide-aroused MRC-5 cell injury via regulating microRNA-31-3p (2019-12-02)
期刊：BIOFACTORS
影響因子 ：3.6
引用產(chǎn)品： MRC-5 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基 , 特級(jí)胎牛血清
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識(shí)別碼示意圖
娜胡文君.png "邱國(guó)娜/胡文君")
.png "梅文強(qiáng)")
