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產(chǎn)品概述
| 名稱 | HL-60 (人原髓細胞白血病細胞) (STR鑒定正確) |
| 別稱 | HL 60; HL60 |
| 種屬 | 人 |
| 生長特性 | 懸浮細胞 |
| 細胞形態(tài) | 原粒細胞 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 3×10^5-1×10^6cells/mL |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項 | 該細胞為懸浮細胞，請注意離心收集細胞懸液；請勿直接倒掉細胞培養(yǎng)液。 |
| 背景描述 | HL-60細胞是一株早幼粒細胞；HL-60細胞源自一位患有急性粒-單核細胞白血病的36歲白人女性。HL-60細胞自發(fā)分化，丁酸鹽、次黃嘌呤、佛波醇、肉豆蔻酸、DMSO(1%-1.5%)、放線菌素D和視黃酸均可以促進分化。HL-60細胞表現(xiàn)出吞噬活性，并對趨化刺激有響應；HL-60細胞致癌基因myc表達陽性。 |
| 年齡（性別） | 女性；36歲 |
| 組織來源 | 外周血；早幼粒細胞；急性粒－單核細胞白血病 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 白血病細胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~28-40 hours |
| 致瘤性 | Yes, in nude mice (subcutaneous myeloid tumors).Yes, in semi-solid media. |
| 受體表達情況 | complement, expressed;Fc, expressed |
| 基因表達情況 | tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid, myc+ |
| 保藏機構(gòu) | ATCC; CCL-240 BCRC; 60027 BCRJ; 0104 DSMZ; ACC-3 ECACC; 98070106 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 13,14 D2S1338 17 D3S1358 16 D5S818 12 D7S820 11,12 D8S1179 12,13 D13S317 8,11 D16S539 11 D18S51 14,15 D19S433 14 D21S11 29,30 FGA 21,24 PentaD 10,12 PentaE 13,14 TH01 7,8 TPOX 8,11 vWA 16 D6S1043 12 D12S391 18,20 D2S441 10,14 -
STR鑒定圖
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參考文獻
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Inhibiting Neutrophil Extracellular Trap Formation through Iron Regulation for Enhanced Cancer Immunotherapy (2025-02-26)
期刊：ACS Nano
影響因子 ：15.8
引用產(chǎn)品： HL-60 細胞
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Astragaloside IV- loaded biomimetic nanoparticles target IκBα to regulate neutrophil extracellular trap formation for sepsis therapy (2025-02-28)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-025-03260-x
影響因子 ：10.6
引用產(chǎn)品： 小鼠外周血中性粒細胞 , MLE-12細胞專用培養(yǎng)基 , HL-60 細胞 , 人臍靜脈內(nèi)皮細胞
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Neutrophil-like cell membrane-coated metal-organic frameworks for siRNA delivery targeting NOX4 to alleviate oxidative stress in acute ischemic injury (2025-02-28)
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2025.02.061
影響因子 ：9.4
引用產(chǎn)品： HL-60 細胞 , RAW 264.7 細胞 , 人臍靜脈內(nèi)皮細胞 , 293T [HEK-293T] 細胞
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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression (2025-01-18)
期刊：Cell Reports
DOI：10.1016/j.celrep.2024.115226
影響因子 ：7.5
引用產(chǎn)品： IMDM 培養(yǎng)基 , HL-60 細胞 , 293T [HEK-293T] 細胞 , MIA PaCa-2 細胞 , RPMI-1640 培養(yǎng)基 , 磷酸鹽緩沖液（PBS） 1×
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Discovery of a selective and reversible LSD1 inhibitor with potent anticancer effects in vitro and in vivo (2025-02-20)
期刊：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
DOI：10.1080/14756366.2025.2466093
影響因子 ：5.6
引用產(chǎn)品： PC-3 細胞 , Caco-2 細胞 , Hep G2 細胞 , Hep 3B2.1-7 細胞 , HuH-6 細胞 , HuH-7 細胞 , MCF7 [MCF-7] 細胞 , HL-60 細胞 , NIH:OVCAR-3 [OVCAR3] 細胞 , A549 [A-549] 細胞
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Glycyrrhizic acid reduces neutrophil extracellular trap formation to ameliorate colitis-associated colorectal cancer by inhibiting peptidyl arginine deiminase 4 (2025-01-07)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：4.8
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Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease (2025-01-22)
期刊：RESPIRATORY RESEARCH
DOI：10.1186/s12931-025-03111-1
影響因子 ：4.7
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N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2 (2024-05-31)
期刊：Molecular Cancer
DOI：10.1186/s12943-024-02013-y
影響因子 ：27.7
引用產(chǎn)品： 293T [HEK-293T] 細胞 , HL-60 細胞 , THP-1 細胞 , NB4 細胞 , DMEM高糖完全培養(yǎng)基（含10% FBS） , IMDM完全培養(yǎng)基（含10% FBS） , RPMI-1640完全培養(yǎng)基（含10% FBS）
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Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS (2024-03-12)
期刊：Cellular & Molecular Immunology
DOI：10.1038/s41423-024-01146-w
影響因子 ：24.1
引用產(chǎn)品： HL-60 細胞
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Ozone-delivering nanocomposite hydrogel for acute Staphylococcus aureus osteomyelitis treatment via neutrophil regulation (2024-04-10)
期刊：CHEMICAL ENGINEERING JOURNAL
影響因子 ：15.1
引用產(chǎn)品： HL-60 細胞
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A cationic hydrogel with anti-IL-17A-specific nanobodies for rheumatoid arthritis treatment via inhibition of inflammatory activities of neutrophils (2024-09-20)
期刊：Nano Today
DOI：10.1016/j.nantod.2024.102507
影響因子 ：13.2
引用產(chǎn)品： HL-60 細胞 , RAW 264.7 細胞
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Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis (2024-02-02)
期刊：Redox Biology
DOI：10.1016/j.redox.2024.103072
影響因子 ：11.4
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A PET Probe Targeting Polyamine Transport System for Precise Tumor Diagnosis and Therapy (2024-04-25)
期刊：Asian Journal of Pharmaceutical Sciences
DOI：10.1016/j.ajps.2024.100924
影響因子 ：10.2
引用產(chǎn)品： HL-60 細胞 , SK-OV-3 細胞
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Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration (2024-08-07)
期刊：ACTA PHARMACOLOGICA SINICA
DOI：10.1038/s41401-024-01352-2
影響因子 ：6.9
引用產(chǎn)品： IMDM 培養(yǎng)基 , HL-60 細胞
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Immune infiltration-related genes regulate the progression of AML by invading the bone marrow microenvironment (2024-07-12)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2024.1409945
影響因子 ：5.7
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Assessing immune hepatotoxicity of troglitazone with a versatile liver-immune-microphysiological-system (2024-05-30)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1335836
影響因子 ：5.6
引用產(chǎn)品： HL-60 細胞 , NK-92 細胞 , NK-92細胞專用培養(yǎng)基
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Targeting protein tyrosine phosphatase non-receptor type 6 (PTPN6) as a therapeutic strategy in acute myeloid leukemia (2024-12-21)
期刊：CELL BIOLOGY AND TOXICOLOGY
DOI：10.1007/s10565-024-09965-3
影響因子 ：5.3
引用產(chǎn)品： HL-60 細胞
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GANT61 surmounts drug resistance of ADR by upregulating lysosome activities and reducing BCL2 expression in HL-60/ADR cells (2024-12-26)
期刊：Cancer Cell International
DOI：10.1186/s12935-024-03626-5
影響因子 ：5.3
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Sequential Immune Acquisition of Monoclonal Antibodies Enhances Phagocytosis of Acinetobacter baumannii by Recognizing ATP Synthase (2024-09-29)
期刊：Vaccines
影響因子 ：5.2
引用產(chǎn)品： HL-60 細胞
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Neutrophil PPIF exacerbates lung ischemia–reperfusion injury after lung transplantation by promoting calcium overload-induced neutrophil extracellular traps formation (2024-09-04)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.113051
影響因子 ：4.8
引用產(chǎn)品： HL-60 細胞
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Neutrophil-to-lymphocyte ratio in colorectal tissue affects prognosis in patients with colorectal cancer (2024-05-15)
期刊：PATHOLOGY
DOI：10.1016/j.pathol.2024.03.003
影響因子 ：4.5
引用產(chǎn)品： HL-60 細胞 , HCT 116 細胞 , LoVo 細胞 , HT-29 細胞 , H9 [derivative of HuT 78] 細胞
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Identifying PTAFR as a hub gene in atherosclerosis: implications for NETosis and disease progression (2024-12-21)
期刊：Human Genomics
DOI：10.1186/s40246-024-00708-3
影響因子 ：3.8
引用產(chǎn)品： HL-60 細胞
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Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway (2024-07-01)
期刊：Lupus Science & Medicine
影響因子 ：3.7
引用產(chǎn)品： HL-60 細胞
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Activation of non-classical Wnt signaling pathway effectively enhances HLA-A presentation in acute myeloid leukemia (2024-06-19)
期刊：Frontiers in Oncology
影響因子 ：3.5
引用產(chǎn)品： MOLM-13 細胞 , 人骨髓造血干細胞完全培養(yǎng)基 , 人骨髓造血干細胞 , HL-60 細胞 , THP-1 細胞
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ZNF521 promotes acute myeloid leukemogenesis by suppressing the expression and acetylation of SMC3 (2024-09-06)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e37528
影響因子 ：3.4
引用產(chǎn)品： THP-1 細胞 , HL-60 細胞 , 293T [HEK-293T] 細胞
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Correlating gene expression levels with transcription factor binding sites facilitates identification of key transcription factors from transcriptome data (2024-11-29)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2024.1511456
影響因子 ：2.8
引用產(chǎn)品： MOLM-13 細胞 , HL-60 細胞 , U-937 細胞 , OCI-AML-3 細胞
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NAP1L5 promotes epithelial–mesenchymal transition by regulating PEG10 expression in acute myeloid leukaemia (2024-11-13)
期刊：LEUKEMIA RESEARCH
DOI：10.1016/j.leukres.2024.107623
影響因子 ：2.1
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High STAT4 expression correlates with poor prognosis in acute myeloid leukemia and facilitates disease progression by upregulating VEGFA expression (2024-05-09)
期刊：Open Medicine
影響因子 ：2.1
引用產(chǎn)品： KG-1 細胞 , HL-60 細胞 , Kasumi-1 細胞 , HUV-EC-C [HUVEC]細胞專用培養(yǎng)基 , HL-60細胞專用培養(yǎng)基 , NB4細胞專用培養(yǎng)基 , Kasumi-1細胞專用培養(yǎng)基 , NB4 細胞 , HUV-EC-C [HUVEC] 細胞
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CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients (2023-09-22)
期刊：Nature Communications
DOI：10.1038/s41467-023-41484-3
影響因子 ：16.6
引用產(chǎn)品： HL-60 細胞
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Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligand (2023-06-01)
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2023.121080
影響因子 ：11.2
引用產(chǎn)品： HL-60 細胞
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METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling. (2023-03-14)
期刊：Cell Reports
DOI：10.1016/j.celrep.2023.112259
影響因子 ：8.8
引用產(chǎn)品： HL-60 細胞 , 293T/17 細胞
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Multifunctional targetable liposomal drug delivery system in the management of leukemia: Potential, opportunities, and emerging strategies (2023-05-13)
期刊：LIFE SCIENCES
影響因子 ：6.1
引用產(chǎn)品： HL-60 細胞 , K-562 [K562] 細胞
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Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis (2023-10-26)
期刊：Communications Biology
DOI：10.1038/s42003-023-05473-y
影響因子 ：5.9
引用產(chǎn)品： HL-60 細胞
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Multiomic landscape of immune pathogenesis in Kimura's disease (2023-04-01)
期刊：iScience
DOI：10.1016/j.isci.2023.106559
影響因子 ：5.8
引用產(chǎn)品： HL-60 細胞
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Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia (2023-01-31)
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影響因子 ：4.8
引用產(chǎn)品： HL-60 細胞 , Kasumi-1 細胞 , KG-1 細胞
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Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling (2023-05-03)
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e15826
影響因子 ：4.0
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Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells: hsa_circ_0013880/USP32/Rap1b in acute myeloid leukemia (2023-03-23)
期刊：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
影響因子 ：3.7
引用產(chǎn)品： HL-60 細胞 , U-937 細胞 , IMDM 培養(yǎng)基
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Role of Lipocalin-2 in N1/N2 Neutrophil Polarization After Stroke (2023-05-29)
期刊：CNS & Neurological Disorders-Drug Targets
DOI：10.2174/1871527322666230417112850
影響因子 ：3.0
引用產(chǎn)品： HL-60 細胞
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Hyposterolactone A, a 3α-Hydroxy Steroidal Lactone from the Deep-Sea-Derived Fungus Hypocrea sp. ZEN14 (2023-06-02)
期刊：CHEMISTRY & BIODIVERSITY
影響因子 ：2.9
引用產(chǎn)品： HuH-7 細胞 , Hep G2 細胞 , HL-60 細胞 , Jurkat, Clone E6-1 細胞
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CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis (2023-06-05)
期刊：Hematology
DOI：10.1080/16078454.2023.2220522
影響因子 ：1.9
引用產(chǎn)品： HL-60 細胞 , Kasumi-1 細胞 , 293T [HEK-293T] 細胞
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Artesunate reverses cytarabine resistance in acute myeloid leukemia by blocking the JAK/STAT3 signaling (2023-10-10)
期刊：Hematology
DOI：10.1080/16078454.2023.2255802
影響因子 ：1.9
引用產(chǎn)品： Annexin V-FITC/PI熒光雙染細胞凋亡檢測試劑盒 , HSPC-1 細胞 , HL-60 細胞
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Circ_0001602 aggravates the progression of acute myeloid leukemia by regulating the miR-192-5p/ZBTB20 axis (2023-08-10)
期刊：Hematology
DOI：10.1080/16078454.2023.2240133
影響因子 ：1.9
引用產(chǎn)品： THP-1 細胞 , HL-60 細胞 , NB4 細胞 , 293T [HEK-293T] 細胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清 , IMDM 培養(yǎng)基 , RPMI-1640 培養(yǎng)基
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The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability (2022-02-25)
期刊：Experimental And Molecular Medicine
DOI：10.1038/s12276-022-00735-x
影響因子 ：12.8
引用產(chǎn)品： HL-60 細胞
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Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization (2022-01-18)
期刊：LAB ON A CHIP
影響因子 ：6.1
引用產(chǎn)品： A549 [A-549] 細胞 , MCF7 [MCF-7] 細胞 , Hela 細胞 , HL-60 細胞
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RAB3D/MDM2/β-catenin/c-MYC axis exacerbates the malignant behaviors of acute myeloid leukemia cells in vitro and in vivo (2022-10-24)
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00549-z
影響因子 ：5.9
引用產(chǎn)品： HL-60 細胞 , U-937 細胞 , Kasumi-1 細胞 , KG-1 細胞
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Comprehensive analysis of ferroptosis-related gene signatures as a potential therapeutic target for acute myeloid leukemia: A bioinformatics analysis and experimental verification (2022-08-11)
期刊：Frontiers in Oncology
影響因子 ：5.7
引用產(chǎn)品： Kasumi-1 細胞 , HL-60 細胞
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LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit (2021-05-18)
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03767-9
影響因子 ：9.0
引用產(chǎn)品： Kasumi-1 細胞 , KG-1 細胞 , HL-60 細胞 , IMDM 培養(yǎng)基 , RPMI-1640 培養(yǎng)基
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Estrone-targeted liposomes for mitoxantrone delivery via estrogen receptor: In vivo targeting efficacy, antitumor activity, acute toxicity and pharmacokinetics (2021-03-02)
期刊：European Journal Of Pharmaceutical Sciences
DOI：10.1016/j.ejps.2021.105780
影響因子 ：4.6
引用產(chǎn)品： HL-60 細胞
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A Novel Phenoxazine-based Fluorescent Probe for the Detection of HOCl in Living Cells (2020-05-05)
期刊：Zeitschrift Fur Anorganische Und Allgemeine Chemie
影響因子 ：1.4
引用產(chǎn)品： RAW 264.7 細胞 , HL-60 細胞
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Oestrone‐targeted liposomes for mitoxantrone delivery via oestrogen receptor – synthesis, physicochemical characterization and in‐vitro evaluation (2017-04-26)
期刊：Journal of Pharmacy and Pharmacology
影響因子 ：3.3
引用產(chǎn)品： HL-60 細胞
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