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PLC/PRF/5 (人肝癌亞力山大細(xì)胞) (STR鑒定正確)
貨號：CL-0415
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價格： ￥2000
生長培養(yǎng)基：MEM（含NEAA）＋10% FBS＋1% P/S
產(chǎn)品概述
| 名稱 | PLC/PRF/5 (人肝癌亞力山大細(xì)胞) (STR鑒定正確) |
| 別稱 | PLC-PRF-5; PLC PRF 5; PLC/PRF5; PLCPRF5; PLC-8024; PLC8024; PLC; Alexander cells; Alexander; Primary Liver Carcinoma/Poliomyelitis Research Foundation/5 |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | PLC/PRF/5細(xì)胞分泌乙肝病毒表面抗原(HBsAg)；PLC/PRF/5細(xì)胞原先被支原體污染，后用BM-cycline去除支原體。 |
| 組織來源 | 肝癌；亞力山大細(xì)胞 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 肝膽癌細(xì)胞 |
| 生物安全等級 | BSL-2 [Cells contain hepatitis B] |
| 倍增時間 | ~36-48 hours |
| 基因表達(dá)情況 | hepatitis virus B surface antigen (HBsAg) |
| 保藏機(jī)構(gòu) | ATCC; CRL-8024 ECACC; 85061113 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 10 D2S1338 19,22 D3S1358 15 D5S818 12 D7S820 9,11 D8S1179 13,16 D13S317 11,12 D16S539 13 D18S51 17 D19S433 11,13 D21S11 30,33.2 FGA 19.2,25 PentaD 6,10 PentaE 10,16 TH01 8 TPOX 8 vWA 15,16 D6S1043 13,21 D12S391 15,20 D2S441 12,14 -
STR鑒定圖
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參考文獻(xiàn)
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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration (2025-02-19)
期刊：Chinese Medicine
DOI：10.1186/s13020-025-01061-w
影響因子 ：5.3
引用產(chǎn)品： PLC/PRF/5 細(xì)胞
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The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine (2024-06-12)
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01323-4
影響因子 ：13.7
引用產(chǎn)品： Hep G2 細(xì)胞 , B16 細(xì)胞 , PLC/PRF/5 細(xì)胞
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GPR56 facilitates hepatocellular carcinoma metastasis by promoting the TGF-β signaling pathway (2024-10-01)
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-07095-6
影響因子 ：8.1
引用產(chǎn)品： PLC/PRF/5 細(xì)胞 , 特級胎牛血清
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RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling (2024-02-18)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-04964-8
影響因子 ：7.4
引用產(chǎn)品： Hep 3B2.1-7 細(xì)胞 , HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , Li-7 細(xì)胞 , THLE-2 細(xì)胞
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Design, synthesis, and antitumor activities of novel ureido/thioureido derivatives with a 4-phenylthiazol-2-amine scaffold (2024-07-02)
期刊：Journal of Saudi Chemical Society
DOI：10.1016/j.jscs.2024.101900
影響因子 ：5.8
引用產(chǎn)品： MCF7 [MCF-7] 細(xì)胞 , PLC/PRF/5 細(xì)胞 , HuH-7 細(xì)胞 , Hep G2 細(xì)胞
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Transcription factor E2F4 facilitates SUMOylation to promote HCC progression through interaction with LIN9 (2024-09-02)
期刊：INTERNATIONAL JOURNAL OF ONCOLOGY
影響因子 ：4.5
引用產(chǎn)品： Hep G2 細(xì)胞 , HCCLM3 細(xì)胞 , HuH-7 細(xì)胞 , HuH-6 細(xì)胞 , PLC/PRF/5 細(xì)胞
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MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway (2024-08-23)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2024.111366
影響因子 ：4.4
引用產(chǎn)品： HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞
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The extract of an herbal medicine Chebulae fructus inhibits hepatocellular carcinoma by suppressing the Apelin/APJ system (2024-05-30)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1413463
影響因子 ：4.4
引用產(chǎn)品： Hep G2 細(xì)胞 , PLC/PRF/5 細(xì)胞 , HuH-7 細(xì)胞 , HCCLM3 細(xì)胞 , Hep 3B2.1-7 細(xì)胞
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New HCC Subtypes Based on CD8 Tex-Related lncRNA Signature Could Predict Prognosis, Immunological and Drug Sensitivity Characteristics of Hepatocellular Carcinoma (2024-07-05)
期刊：Journal of Hepatocellular Carcinoma
影響因子 ：4.2
引用產(chǎn)品： HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , HL-7702 [L-02; LO2] 細(xì)胞 , Hep G2 細(xì)胞 , Hep-G2/2.2.15 細(xì)胞
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Combining a glycolysis?related prognostic model based on scRNA?Seq with experimental verification identifies ZFP41 as a potential prognostic biomarker for HCC (2024-03-19)
期刊：Molecular Medicine Reports
影響因子 ：3.4
引用產(chǎn)品： 293T [HEK-293T] 細(xì)胞 , HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞
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Liquidambaric acid inhibits the proliferation of hepatocellular carcinoma cells by targeting PPARα-RXRα to down-regulate fatty acid metabolism (2024-07-25)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2024.117042
影響因子 ：3.3
引用產(chǎn)品： Li-7 細(xì)胞 , Annexin V-FITC/PI熒光雙染細(xì)胞凋亡檢測試劑盒 , Hep G2 細(xì)胞 , HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , Hep 3B2.1-7 細(xì)胞
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STAMBPL1, transcriptionally regulated by SREBP1, promotes malignant behaviors of hepatocellular carcinoma cells via Wnt/β-catenin signaling pathway (2024-08-16)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23801
影響因子 ：3.0
引用產(chǎn)品： PLC/PRF/5 細(xì)胞 , Hep 3B2.1-7 細(xì)胞
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The diagnostic, prognostic, drug sensitivity and ceRNA internet of PPP4R1 in liver hepatocellular carcinoma (LIHC) (2024-02-26)
期刊：Translational Cancer Research
影響因子 ：0.9
引用產(chǎn)品： LX-2 細(xì)胞 , HLE 細(xì)胞 , HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , Hep G2 細(xì)胞 , 特級胎牛血清
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Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT (2023-10-22)
期刊：Advanced Science
影響因子 ：15.1
引用產(chǎn)品： HCCLM3 細(xì)胞 , Hep G2 細(xì)胞 , HuH-7 細(xì)胞 , BEL-7404 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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Conjugating 4β-NH-(5-Aminoindazole)-podophyllotoxin and Galectin-1-Targeted Aptamer for Synergistic Chemo-Immunotherapy of Hepatocellular Carcinoma (2023-05-04)
期刊：Advanced Healthcare Materials
影響因子 ：10.0
引用產(chǎn)品： Hep G2 細(xì)胞 , HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , SNU387 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , Hepa 1-6 細(xì)胞
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Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination (2023-11-25)
期刊：ONCOGENE
DOI：10.1038/s41388-023-02898-x
影響因子 ：8.0
引用產(chǎn)品： MHCC97-L 細(xì)胞 , Hep G2 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , HuH-7 細(xì)胞
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Targeting NAD+ metabolism of hepatocellular carcinoma cells by lenvatinib promotes M2 macrophages reverse polarization, suppressing the HCC progression (2023-05-19)
期刊：Hepatology International
DOI：10.1007/s12072-023-10544-7
影響因子 ：6.6
引用產(chǎn)品： Li-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , SNU-182 細(xì)胞 , SNU-387 細(xì)胞 , RAW 264.7 細(xì)胞
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Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β?catenin pathway in liver cancer (2023-08-30)
期刊：Oncology Letters
影響因子 ：2.9
引用產(chǎn)品： HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , Hep G2 細(xì)胞 , Li-7 細(xì)胞 , RPMI-1640 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , 青霉素-鏈霉素溶液 (雙抗)，100×
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VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4 (2022-10-14)
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00540-8
影響因子 ：5.9
引用產(chǎn)品： SK-Hep-1 細(xì)胞 , PLC/PRF/5 細(xì)胞 , HuH-7 細(xì)胞 , Hep 3B2.1-7 細(xì)胞
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SLC39A10 Upregulation Predicts Poor Prognosis, Promotes Proliferation and Migration, and Correlates with Immune Infiltration in Hepatocellular Carcinoma (2022-11-14)
期刊：Journal of Hepatocellular Carcinoma
影響因子 ：5.0
引用產(chǎn)品： MHCC97-L 細(xì)胞 , HCCLM3 細(xì)胞 , Hep G2 細(xì)胞 , HL-7702 [L-02; LO2] 細(xì)胞 , PLC/PRF/5 細(xì)胞 , HuH-7 細(xì)胞 , Hep 3B2.1-7 細(xì)胞
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LncRNA AC026401.3 interacts with OCT1 to intensify sorafenib and lenvatinib resistance by activating E2F2 signaling in hepatocellular carcinoma (2022-09-06)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113335
影響因子 ：4.1
引用產(chǎn)品： Hep 3B2.1-7 細(xì)胞 , Hep G2 細(xì)胞 , HuH-7 細(xì)胞 , MHCC97-L 細(xì)胞 , PLC/PRF/5 細(xì)胞 , MIHA 細(xì)胞
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PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway (2021-10-30)
期刊：Acta Biochimica Et Biophysica Sinica
影響因子 ：3.5
引用產(chǎn)品： HuH-7 細(xì)胞 , SK-Hep-1 細(xì)胞 , PLC/PRF/5 細(xì)胞
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