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THLE-2 (人肝永生化細(xì)胞) (STR鑒定正確)
貨號：CL-0833
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價格： ￥2500
生長培養(yǎng)基：THLE-2 專用培養(yǎng)基
產(chǎn)品概述
| 名稱 | THLE-2 (人肝永生化細(xì)胞) (STR鑒定正確) |
| 別稱 | THLE2; Transformed Human Liver Epithelial-2 |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55%DM/F12+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:6 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | THLE-2 is an epithelial cell that was isolated from the left lobe of a donor.THLE-2 and THLE-3 cells express phenotypic characteristics of normal adult liver epithelial cells. They are nontumorigenic when injected into athymic nude mice, have near-diploid karyotypes, and do not express alpha-fetoprotein. [RF84750] THLE-2 and THLE-3 cells metabolize benzo[a]pyrene, N-nitrosodimethylamine, and aflatoxin B1 to their ultimate carcinogenic metabolites that adduct DNA, which indicates functional cytochrome P450 pathways. |
| 年齡（性別） | 男性 |
| 組織來源 | 肝臟；左葉 |
| 細(xì)胞類型 | 轉(zhuǎn)化細(xì)胞系 |
| 生物安全等級 | BSL-2 |
| 致瘤性 | No; No, nude mice |
| 保藏機(jī)構(gòu) | ATCC; CRL-2706 |
STR鑒定
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STR位點信息
Amelogenin X, Y CSF1PO 11,13 D2S1338 17,23 D3S1358 14,15 D5S818 11,13 D7S820 10,12 D8S1179 13 D13S317 8,12 D16S539 11,13 D18S51 13,16 D19S433 14 D21S11 30,32.2 FGA 22,24 PentaD 10,13 PentaE 12,13 TH01 7,9.3 TPOX 8,11 vWA 16,17 D6S1043 12,18 D12S391 21,23 D2S441 11 -
STR鑒定圖
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參考文獻(xiàn)
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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis (2025-01-27)
期刊：Molecular Cancer
DOI：10.1186/s12943-024-02224-3
影響因子 ：27.7
引用產(chǎn)品： THLE-2 細(xì)胞
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Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (2025-01-21)
期刊：Advanced Science
影響因子 ：14.3
引用產(chǎn)品： THLE-2 細(xì)胞 , THLE-2細(xì)胞專用培養(yǎng)基
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Revealing Molecular Connections between Dissolved Organic Matter in Surface Water Sources and Their Cytotoxicity Influenced by Chlorination Disinfection (2025-01-27)
期刊：ENVIRONMENTAL SCIENCE & TECHNOLOGY
影響因子 ：10.8
引用產(chǎn)品： THLE-2 細(xì)胞
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The role of transketolase in the immunotherapy and prognosis of hepatocellular carcinoma: a multi-omics approach (2025-03-31)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2025.1529029
影響因子 ：5.7
引用產(chǎn)品： Hep G2 細(xì)胞 , THLE-2 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification (2025-03-05)
期刊：Biology Direct
DOI：10.1186/s13062-025-00620-3
影響因子 ：5.7
引用產(chǎn)品： THLE-2 細(xì)胞 , THLE-2細(xì)胞專用培養(yǎng)基
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Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma (2025-02-14)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2025.114278
影響因子 ：4.8
引用產(chǎn)品： THLE-2 細(xì)胞 , THLE-2細(xì)胞專用培養(yǎng)基
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The promoting effect of the POU3F2/METTL16/PFKM cascade on glycolysis and tumorigenesis of hepatocellular carcinoma: Role of the POU3F2/METTL16/PFKM axis in HCC (2025-01-03)
期刊：Annals of Hepatology
DOI：10.1016/j.aohep.2025.101776
影響因子 ：3.7
引用產(chǎn)品： THLE-2 細(xì)胞 , THLE-2細(xì)胞專用培養(yǎng)基
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miR-183-5p-enriched extracellular vesicles promote the crosstalk between hepatocellular carcinoma cell and endothelial cell via SIK1/PI3K/AKT and CCL20/CCR6 signaling pathways (2025-03-06)
期刊：Frontiers in Oncology
影響因子 ：3.5
引用產(chǎn)品： MHCC97-L 細(xì)胞 , HuH-7 細(xì)胞 , HuH-1 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , THLE-2 細(xì)胞 , 人臍靜脈內(nèi)皮細(xì)胞
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Deubiquitinase USP28 promotes the malignant progression and radio-resistance of hepatocellular carcinoma by stabilizing WDHD1 (2025-02-10)
期刊：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
DOI：10.1007/s00210-025-03793-w
影響因子 ：3.1
引用產(chǎn)品： THLE-2 細(xì)胞 , THLE-2細(xì)胞專用培養(yǎng)基 , HuH-7 細(xì)胞 , DMEM高糖 培養(yǎng)基
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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway (2025-01-29)
期刊：PLoS One
DOI：10.1371/journal.pone.0318450
影響因子 ：2.9
引用產(chǎn)品： THLE-2 細(xì)胞 , AML12 細(xì)胞
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MICAL1 Mediates TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma by Activating Smad2/3 (2025-02-15)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-025-01668-8
影響因子 ：1.8
引用產(chǎn)品： THLE-2 細(xì)胞 , TGFB1/TGFβ1/TGF-β1, Human, Recombinant
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Accumulation of TOX high mobility group box family member 3 promotes the oncogenesis and development of hepatocellular carcinoma through the MAPK signaling pathway (2024-03-09)
期刊：MedComm
DOI：10.1002/mco2.510
影響因子 ：9.9
引用產(chǎn)品： THLE-2 細(xì)胞
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O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export (2024-07-01)
期刊：International Journal of Biological Sciences
影響因子 ：8.2
引用產(chǎn)品： HuH-7 細(xì)胞 , THLE-2 細(xì)胞 , Hep 3B2.1-7 細(xì)胞
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RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling (2024-02-18)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-04964-8
影響因子 ：7.4
引用產(chǎn)品： Hep 3B2.1-7 細(xì)胞 , HuH-7 細(xì)胞 , PLC/PRF/5 細(xì)胞 , Li-7 細(xì)胞 , THLE-2 細(xì)胞
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Development of cantharidin/baicalin co-delivery system based on mitochondrial targeting strategy for enhanced hepatocellular carcinoma therapy (2024-08-03)
期刊：Applied Materials Today
DOI：10.1016/j.apmt.2024.102374
影響因子 ：7.2
引用產(chǎn)品： Hep G2 細(xì)胞 , HuH-7 細(xì)胞 , THLE-2 細(xì)胞
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TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population (2024-02-22)
期刊：DIABETES OBESITY & METABOLISM
影響因子 ：5.8
引用產(chǎn)品： THLE-2 細(xì)胞 , Hep G2 細(xì)胞
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USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1 (2024-10-08)
期刊：Communications Biology
DOI：10.1038/s42003-024-06999-5
影響因子 ：5.2
引用產(chǎn)品： Hep G2 細(xì)胞 , SMMC-7721 細(xì)胞 , HuH-7 細(xì)胞 , HCCLM3 細(xì)胞 , THLE-2 細(xì)胞
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The prognostic significance and potential mechanism of PFDN4 in hepatocellular carcinoma (2024-12-06)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.113761
影響因子 ：4.8
引用產(chǎn)品： THLE-2 細(xì)胞 , MHCC97-L 細(xì)胞 , HuH-7 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , HLF-a 細(xì)胞 , SNU-449 細(xì)胞
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Schisandra chinensis Bee Pollen Extract Inhibits Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells via Ferroptosis-, Wnt-, and Focal Adhesion–Signaling Pathways (2024-07-02)
期刊：Drug Design Development and Therapy
影響因子 ：4.7
引用產(chǎn)品： Hep G2 細(xì)胞 , Hep G2細(xì)胞專用培養(yǎng)基 , THLE-2 細(xì)胞
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HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway (2024-04-05)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23723
影響因子 ：4.6
引用產(chǎn)品： THLE-2 細(xì)胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清 , THLE-2細(xì)胞專用培養(yǎng)基
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Tumor exosomal RNPEP promotes lung metastasis of liver cancer via inducing cancer-associated fibroblast activation (2024-12-10)
期刊：CANCER SCIENCE
影響因子 ：4.5
引用產(chǎn)品： THLE-2 細(xì)胞 , THLE-2細(xì)胞專用培養(yǎng)基
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LINC02987 suppression hepatocellular carcinoma progression by modulating autophagy via the miR-338-3p/ATG12 axis (2024-12-31)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.114398
影響因子 ：3.3
引用產(chǎn)品： HuH-7 細(xì)胞 , Li-7 細(xì)胞 , THLE-2 細(xì)胞 , SK-Hep-1 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , Hep G2 細(xì)胞
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Cancer-associated fibroblasts-derived exosomal ZNF250 promotes the proliferation, migration, invasion, and immune escape of hepatocellular carcinoma cells by transcriptionally activating PD-L1 (2024-09-09)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影響因子 ：3.2
引用產(chǎn)品： DMEM高糖 培養(yǎng)基 , 青霉素-鏈霉素溶液（雙抗），100× , Hep 3B2.1-7 細(xì)胞 , 特級胎牛血清 , THLE-2 細(xì)胞 , RPMI-1640 培養(yǎng)基
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Circ_0084615 promotes epithelial-mesenchymal transition-mediated tumor progression in hepatocellular carcinoma (2024-06-03)
期刊：Annals of Gastroenterological Surgery
影響因子 ：2.9
引用產(chǎn)品： MHCC97-L 細(xì)胞 , Hep 3B2.1-7 細(xì)胞 , THLE-2 細(xì)胞 , BEL-7405 細(xì)胞 , SK-Hep-1 細(xì)胞
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METTL3-mediated m6A modification of ZNF384 promotes hepatocellular carcinoma progression by transcriptionally activating ACSM1 (2024-09-29)
期刊：Clinical & Translational Oncology
DOI：10.1007/s12094-024-03701-3
影響因子 ：2.8
引用產(chǎn)品： DMEM高糖完全培養(yǎng)基（含10% FBS） , THLE-2 細(xì)胞 , DMEM高糖 培養(yǎng)基 , THLE-2細(xì)胞專用培養(yǎng)基
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Overexpression of ZFP69B promotes hepatocellular carcinoma growth by upregulating the expression of TLX1 and TRAPPC9 (2024-09-11)
期刊：Cell Division
DOI：10.1186/s13008-024-00131-z
影響因子 ：2.8
引用產(chǎn)品： THLE-2細(xì)胞專用培養(yǎng)基 , THLE-2 細(xì)胞
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Purpurogallin carboxylic acid exhibits synergistic effects with 5?fluorouracil on liver cancer cells in vitro by targeting ABCG2 (2024-05-08)
期刊：Experimental and Therapeutic Medicine
影響因子 ：2.7
引用產(chǎn)品： THLE-2細(xì)胞專用培養(yǎng)基 , HuH-7 細(xì)胞 , Hep G2 細(xì)胞 , THLE-2 細(xì)胞
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hsa_circ_0072309 Inhibits Oncogenesis in Hepatocellular Carcinoma by Epigenetic Activation of its Host Gene (2024-09-16)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01330-9
影響因子 ：1.8
引用產(chǎn)品： Hep 3B2.1-7 細(xì)胞 , HuH-7 細(xì)胞 , THLE-2 細(xì)胞
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miR-145-5p regulates hepatocellular carcinoma malignant advancement and immune escape via down-regulation of AcylCoA synthase ACSL4 (2024-12-07)
期刊：Biomolecules and Biomedicine
影響因子 ：0.0
引用產(chǎn)品： THLE-2 細(xì)胞
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F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway (2024-09-10)
期刊：Biomolecules and Biomedicine
影響因子 ：
引用產(chǎn)品： THLE-2 細(xì)胞
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KIN17 promotes cell migration and invasion through stimulating the TGF-β/Smad2 pathway in hepatocellular carcinoma (2022-12-05)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23492
影響因子 ：5.1
引用產(chǎn)品： HuH-7 細(xì)胞 , MHCC-97H 細(xì)胞 , Hep G2 細(xì)胞 , MHCC97-L 細(xì)胞 , THLE-2 細(xì)胞
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