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產品概述
| 名稱 | LX-2 (人肝星形細胞) (STR鑒定正確) |
| 別稱 | Lieming Xu-2 |
| 種屬 | 人 |
| 生長特性 | 貼壁細胞 |
| 細胞形態(tài) | 上皮細胞樣 |
| 凍存條件 | 凍存液：55% 基礎培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 細胞類型 | 轉化細胞系 |
| 倍增時間 | ~48-96 hours |
STR鑒定
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STR位點信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 17 D3S1358 13,15 D5S818 11,12 D7S820 11 D8S1179 13 D13S317 11,13 D16S539 13 D18S51 12 D19S433 13,15.2 D21S11 28,31 FGA 21,26 PentaD 12,13,15 PentaE 5,21 TH01 9.3 TPOX 8 vWA 17 D6S1043 11,12 D12S391 15,17 D2S441 11,14 -
STR鑒定圖
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參考文獻
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Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining (2025-01-28)
期刊：Cell Metabolism
DOI：10.1016/j.cmet.2024.12.005
影響因子 ：27.7
引用產品： 青霉素-鏈霉素溶液（雙抗），100× , C2C12 細胞 , LX-2 細胞 , Hepa 1-6 細胞
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Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk (2025-02-19)
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2025.02.017
影響因子 ：14.7
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Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma (2025-01-28)
期刊：Cell Discovery
DOI：10.1038/s41421-024-00747-z
影響因子 ：13.0
引用產品： LX-2 細胞
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in the UK biobank (2025-02-03)
期刊：ANNALS OF MEDICINE
DOI：10.1080/07853890.2025.2458201
影響因子 ：4.9
引用產品： LX-2 細胞
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The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2 (2025-01-18)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2025.114053
影響因子 ：4.8
引用產品： LX-2 細胞
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Triptolide combined with salvianolic acid B alleviates CCL4-induced liver fibrosis by suppressing the Th17/IL-17A axis (2025-02-17)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2025.114300
影響因子 ：4.8
引用產品： LX-2 細胞 , 青霉素-鏈霉素溶液（雙抗），100×
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miR-372-3p represses hepatic stellate cell activation via the RhoC/ROCK pathway (2025-02-14)
期刊：CYTOTECHNOLOGY
DOI：10.1007/s10616-025-00715-9
影響因子 ：2.0
引用產品： LX-2 細胞
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Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence (2024-10-15)
期刊：ADVANCED MATERIALS
影響因子 ：27.4
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An all-in-one tetrazine reagent for cysteine-selective labeling and bioorthogonal activable prodrug construction (2024-04-02)
期刊：Nature Communications
DOI：10.1038/s41467-024-47188-6
影響因子 ：16.6
引用產品： SK-OV-3 細胞 , MCF7 [MCF-7] 細胞 , MDA-MB-231 細胞 , U-87 MG 細胞 , LX-2 細胞 , Hep G2 細胞 , B16-F10 細胞
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RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment (2024-08-27)
期刊：Nature Communications
DOI：10.1038/s41467-024-51571-8
影響因子 ：14.7
引用產品： THP-1 細胞 , RAW 264.7 細胞 , NIH/3T3 細胞 , LX-2 細胞 , 特級胎牛血清
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FGF19-Activated Hepatic Stellate Cells Release ANGPTL4 that Promotes Colorectal Cancer Liver Metastasis (2024-12-24)
期刊：Advanced Science
影響因子 ：14.3
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Cancer Cell-Derived Exosomal miR-500a-3p Modulates Hepatic Stellate Cell Activation and the Immunosuppressive Microenvironment (2024-11-22)
期刊：Advanced Science
影響因子 ：14.3
引用產品： HuH-7 細胞 , LX-2 細胞 , SNU-387 細胞
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MafG/MYH9-LCN2 axis promotes liver fibrosis through inhibiting ferroptosis of hepatic stellate cells (2024-06-13)
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01322-5
影響因子 ：13.7
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Impact of fine particulate matter on liver injury: evidence from human, mice and cells (2024-03-04)
期刊：JOURNAL OF HAZARDOUS MATERIALS
DOI：10.1016/j.jhazmat.2024.133958
影響因子 ：13.6
引用產品： LX-2 細胞
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A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2 (2024-08-05)
期刊：Nature Chemical Biology
DOI：10.1038/s41589-024-01704-3
影響因子 ：12.9
引用產品： LX-2 細胞
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Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP (2024-08-10)
期刊：JOURNAL OF HAZARDOUS MATERIALS
DOI：10.1016/j.jhazmat.2024.135480
影響因子 ：12.2
引用產品： LX-2 細胞
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Multivalent supramolecular fluorescent probes for accurate disease imaging (2024-10-18)
期刊：Science Advances
影響因子 ：11.7
引用產品： RAW 264.7 細胞 , LX-2 細胞 , CT26.WT 細胞 , HK-2 細胞 , AML12 細胞
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Single-cell RNA sequencing reveals reduced intercellular adhesion molecule crosstalk between activated hepatic stellate cells and neutrophils alleviating liver fibrosis in hepatitis B virus transgenic mice post menstrual blood-derived mesenchymal stem cell transplantation (2024-07-22)
期刊：MedComm
DOI：10.1002/mco2.654
影響因子 ：10.7
引用產品： LX-2 細胞
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FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis (2024-04-09)
期刊：Journal of Advanced Research
DOI：10.1016/j.jare.2024.04.004
影響因子 ：10.7
引用產品： LX-2 細胞
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Hepatic stellate cells promote hepatocellular carcinoma development by regulating histone lactylation: Novel insights from single-cell RNA sequencing and spatial transcriptomics analyses (2024-09-10)
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2024.217243
影響因子 ：9.1
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Hepatic Surf4 Deficiency Impairs Serum Amyloid A1 Secretion and Attenuates Liver Fibrosis in Mice (2024-08-05)
期刊：Research
影響因子 ：8.5
引用產品： LX-2 細胞 , LX-2細胞專用培養(yǎng)基
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Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways (2024-01-26)
期刊：ACTA PHARMACOLOGICA SINICA
DOI：10.1038/s41401-024-01226-7
影響因子 ：8.2
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Lichen pectin-containing polysaccharide from Xanthoria elegans and its ability to effectively protect LX-2 cells from H2O2-induced oxidative damage (2024-03-11)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2024.130712
影響因子 ：8.2
引用產品： LX-2 細胞 , DMEM高糖 培養(yǎng)基
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BMP7-Loaded Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorate Liver Fibrosis by Targeting Activated Hepatic Stellate Cells (2024-04-11)
期刊：International Journal of Nanomedicine
影響因子 ：8.0
引用產品： HSC-T6 細胞 , LX-2 細胞 , 293T [HEK-293T] 細胞
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Esculin inhibits hepatic stellate cell activation and CCl4-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway (2024-02-17)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155465
影響因子 ：7.9
引用產品： LX-2 細胞
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Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress (2024-12-30)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.12.055
影響因子 ：7.1
引用產品： AML12 細胞 , Hep G2 細胞 , LX-2 細胞 , 293T [HEK-293T] 細胞
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RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis (2024-04-30)
期刊：Cellular and Molecular Gastroenterology and Hepatology
DOI：10.1016/j.jcmgh.2024.04.005
影響因子 ：7.1
引用產品： Hep G2 細胞 , MHCC97-L 細胞 , HuH-7 細胞 , LX-2 細胞
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Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis (2024-04-26)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.4c00461
影響因子 ：6.8
引用產品： LX-2 細胞
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Catalpol ameliorates liver fibrosis via inhibiting aerobic glycolysis by EphA2/FAK/Src signaling pathway (2024-09-13)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.156047
影響因子 ：6.7
引用產品： LX-2 細胞
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CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation (2024-02-03)
期刊：JOURNAL OF GASTROENTEROLOGY
DOI：10.1007/s00535-023-02068-6
影響因子 ：6.3
引用產品： LX-2 細胞
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Fluorescence imaging sheds light on the immune evasion mechanisms of hepatic stellate cells mediated by superoxide anion (2024-05-10)
期刊：Communications Biology
DOI：10.1038/s42003-024-06245-y
影響因子 ：5.9
引用產品： LX-2 細胞
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Sevelamer reverses liver fibrosis by deactivation of hepatic stellate cells (2024-03-08)
期刊：BIOCHEMICAL PHARMACOLOGY
影響因子 ：5.8
引用產品： LX-2 細胞
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Single-cell and bulk transcriptomic datasets enable the development of prognostic models based on dynamic changes in the tumor immune microenvironment in patients with hepatocellular carcinoma and portal vein tumor thrombus (2024-10-28)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2024.1414121
影響因子 ：5.7
引用產品： DMEM高糖 培養(yǎng)基 , Hep G2 細胞 , HuH-7 細胞 , LX-2 細胞 , 特級胎牛血清
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The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice (2024-04-12)
期刊：BIOCHEMICAL PHARMACOLOGY
影響因子 ：5.3
引用產品： LX-2 細胞
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Targeting hyperactive mitochondria in activated HSCs and inhibition of liver fibrogenesis in mice using sorafenib complex micelles (2024-12-07)
期刊：INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI：10.1016/j.ijpharm.2024.125058
影響因子 ：5.3
引用產品： LX-2 細胞
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Network pharmacology and transcriptomic profiling elucidate the therapeutic effects of Ranunculus ternatus Thunb on liver fibrosis via MK3-NF-κB inhibition (2024-03-08)
期刊：Aging-US
影響因子 ：5.2
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Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells (2024-02-28)
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2024.1344971
影響因子 ：5.2
引用產品： LX-2 細胞 , DMEM高糖 (不含L-谷氨酰胺) 培養(yǎng)基 , DMEM高糖 (不含L-谷氨酰胺) 培養(yǎng)基
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Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice (2024-04-26)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2024.176629
影響因子 ：5.0
引用產品： LX-2 細胞
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Oncolytic Activity of Sindbis Virus with the Help of GM-CSF in Hepatocellular Carcinoma (2024-06-29)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：4.9
引用產品： Hep 3B2.1-7 細胞 , C2C12 細胞 , Hep G2 細胞 , LX-2 細胞 , HuH-7 細胞
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Chrysin exacerbates mitophagy-mediated pyroptosis to inhibit the proliferation of hepatocellular carcinoma cells by targeting p53 (2024-09-23)
期刊：Food Bioscience
DOI：10.1016/j.fbio.2024.105148
影響因子 ：4.8
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Kaempferol from Alpinia officinarum Hance induces G2/M cell cycle arrest in hepatocellular carcinoma cells by regulating the ATM/CHEK2/KNL1 pathway (2024-06-08)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：4.8
引用產品： LX-2 細胞
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Human placental mesenchymal stromal cells promote the formation of CD8+CD122+PD-1+Tregs via CD73/Foxo1 to alleviate liver injury in graft-versus-host disease mice (2024-07-04)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112554
影響因子 ：4.8
引用產品： LX-2 細胞
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Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X (HBX) gene-transfected hepatic stellate cells (2024-06-01)
期刊：Journal of Zhejiang University-SCIENCE B
影響因子 ：4.7
引用產品： LX-2 細胞 , Hep-G2/2.2.15 細胞
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Cordycepin alleviates diabetes mellitus-associated hepatic fibrosis by inhibiting SOX9-mediated Wnt/β-catenin signal axis (2024-09-06)
期刊：BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2024.107812
影響因子 ：4.5
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Role of autophagy-related genes in liver cancer prognosis (2024-05-03)
期刊：GENOMICS
DOI：10.1016/j.ygeno.2024.110852
影響因子 ：4.4
引用產品： MHCC97-L 細胞 , HuH-7 細胞 , 293T [HEK-293T] 細胞 , HCCLM3 細胞 , LX-2 細胞
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System analysis based on weighted gene co-expression analysis identifies SOX7 as a novel regulator of hepatic stellate cell activation and liver fibrosis (2024-08-10)
期刊：FASEB JOURNAL
影響因子 ：4.4
引用產品： LX-2 細胞
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Mechanism Study of Xiaoyao San against Nonalcoholic Steatohepatitis-Related Liver Fibrosis Based on a Combined Strategy of Transcriptome Analysis and Network Pharmacology (2024-08-27)
期刊：Pharmaceuticals
影響因子 ：4.3
引用產品： LX-2 細胞
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The Potential of the lncRNAs ADAMTSL4-AS1, AC067931 and SOCS2-AS1 in Peripheral Blood Mononuclear Cells as Novel Diagnostic Biomarkers for Hepatitis B Virus-Associated Hepatocellular Carcinoma (2024-06-28)
期刊：Journal of Hepatocellular Carcinoma
影響因子 ：4.2
引用產品： HepG2.215 細胞 , Hep 3B2.1-7 細胞 , HuH-7 細胞 , Hep G2 細胞 , LX-2 細胞
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The Role of miR-150-5p/SOCS1 Pathway in Arsenic-Induced Pyroptosis of LX-2 Cells (2024-04-30)
期刊：BIOLOGICAL TRACE ELEMENT RESEARCH
DOI：10.1007/s12011-024-04211-7
影響因子 ：3.9
引用產品： LX-2 細胞
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LINC00942 Alleviates NaAsO2-induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p (2024-04-05)
期刊：BIOLOGICAL TRACE ELEMENT RESEARCH
DOI：10.1007/s12011-024-04167-8
影響因子 ：3.9
引用產品： LX-2 細胞
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Exploring heterogeneous cell population dynamics in different microenvironments by novel analytical strategy based on images (2024-11-06)
期刊：npj Systems Biology and Applications
DOI：10.1038/s41540-024-00459-w
影響因子 ：3.5
引用產品： LX-2 細胞
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Long non-coding RNA LINC01554 overexpression suppresses viability, migration, and invasion of liver cancer cells through regulating miR-148b-3p/EIF4E3 (2024-03-04)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e27319
影響因子 ：3.4
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Lycorine relieves the CCl4-induced liver fibrosis mainly via the JAK2/STAT3 and PI3K/AKT signaling pathways (2024-06-24)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2024.117017
影響因子 ：3.3
引用產品： LX-2 細胞
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Network Pharmacology, Molecular Docking Analysis and Molecular Dynamics Simulation of Scutellaria baicalensis in the Treatment of Liver Fibrosis (2024-05-01)
期刊：CURRENT PHARMACEUTICAL DESIGN
DOI：10.2174/0113816128297074240327090020
影響因子 ：3.1
引用產品： LX-2 細胞
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Expression of SDF-1/CXCR4 and related inflammatory factors in sodium fluoride-treated hepatocytes (2024-06-21)
期刊：PLoS One
DOI：10.1371/journal.pone.0302530
影響因子 ：2.9
引用產品： LX-2 細胞 , LX-2細胞專用培養(yǎng)基
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SIGIRR suppresses hepatitis B virus X protein-induced chronic inflammation in hepatocytes (2024-07-14)
期刊：GENE
DOI：10.1016/j.gene.2024.148768
影響因子 ：2.6
引用產品： HepRG 細胞 , LX-2 細胞
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Wedelolactone attenuates liver fibrosis and hepatic stellate cell activation by suppressing the Hippo pathway (2024-09-14)
期刊：REJUVENATION RESEARCH
影響因子 ：2.2
引用產品： LX-2 細胞
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Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11 (2024-05-13)
期刊：Open Medicine
影響因子 ：2.1
引用產品： DMEM高糖 培養(yǎng)基 , 青霉素-鏈霉素溶液（雙抗），100× , LX-2 細胞
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E2F8—TPX2 axis regulates glycolysis and angiogenesis to promote progression and reduce chemosensitivity of liver cancer (2024-09-21)
期刊：CYTOTECHNOLOGY
DOI：10.1007/s10616-024-00655-w
影響因子 ：2.0
引用產品： 人臍靜脈內皮細胞 , HuH-7 細胞 , LX-2 細胞 , Hep G2 細胞 , Hep 3B2.1-7 細胞 , 293T [HEK-293T] 細胞
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Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice (2023-02-22)
期刊：Military Medical Research
DOI：10.1186/s40779-023-00441-3
影響因子 ：21.1
引用產品： LX-2 細胞
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Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice (2023-04-01)
期刊：Nature Communications
DOI：10.1038/s41467-023-37459-z
影響因子 ：16.6
引用產品： LX-2 細胞
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A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression (2023-05-04)
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2023.04.010
影響因子 ：14.5
引用產品： LX-2 細胞 , 人臍靜脈內皮細胞 , NK-92 細胞 , NK-92細胞專用培養(yǎng)基
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TRIM21 promotes ubiquitination of SARS-CoV-2 nucleocapsid protein to regulate innate immunity (2023-04-13)
期刊：JOURNAL OF MEDICAL VIROLOGY
影響因子 ：12.7
引用產品： LX-2 細胞
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Matrix stiffness triggers lipid metabolic crosstalk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases (2023-08-23)
期刊：CANCER RESEARCH
DOI：10.1158/0008-5472.CAN-23-0025
影響因子 ：11.2
引用產品： LX-2 細胞
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Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells (2023-02-28)
期刊：JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI：10.1016/j.jcis.2023.02.133
影響因子 ：9.9
引用產品： Hela 細胞 , 293 [HEK-293] 細胞 , Hep G2 細胞 , LX-2 細胞
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Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen (2023-01-02)
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2022.12.062
影響因子 ：9.7
引用產品： LX-2 細胞
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The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis (2023-11-30)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-06324-8
影響因子 ：9.0
引用產品： LX-2 細胞
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Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis (2023-11-29)
期刊：Journal of Pharmaceutical Analysis
DOI：10.1016/j.jpha.2023.11.009
影響因子 ：8.8
引用產品： LX-2 細胞
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Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway (2023-04-21)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2023.114653
影響因子 ：7.5
引用產品： LX-2 細胞
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Sappanone A Alleviates the Severity of Carbon Tetrachloride-Induced Liver Fibrosis in Mice (2023-09-04)
期刊：Antioxidants
影響因子 ：7.0
引用產品： AML12 細胞 , RAW 264.7 細胞 , LX-2 細胞
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Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver (2023-08-15)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115374
影響因子 ：6.8
引用產品： RAW 264.7 細胞 , AML12 細胞 , LX-2 細胞
-
Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis (2023-01-23)
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2023.115144
影響因子 ：6.7
引用產品： J774A.1 細胞 , THP-1 細胞 , LX-2 細胞
-
Nanodrug rescues liver fibrosis via synergistic therapy with H2O2 depletion and Saikosaponin b1 sustained release (2023-02-16)
期刊：Communications Biology
DOI：10.1038/s42003-023-04473-2
影響因子 ：5.9
引用產品： LX-2 細胞
-
BRD4 promotes hepatic stellate cells activation and hepatic fibrosis via mediating P300/H3K27ac/PLK1 axis (2023-03-11)
期刊：BIOCHEMICAL PHARMACOLOGY
影響因子 ：5.8
引用產品： LX-2 細胞
-
Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis (2023-02-08)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.6
-
The combination of tetracyclines effectively ameliorates liver fibrosis via inhibition of EphB1/2 (2023-11-21)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111261
影響因子 ：5.6
引用產品： LX-2 細胞
-
Activation of cGAS-STING signaling pathway promotes liver fibrosis and hepatic sinusoidal microthrombosis (2023-11-09)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111132
影響因子 ：5.6
引用產品： LX-2 細胞
-
Gandouling inhibits hepatic fibrosis in Wilson's disease through Wnt-1/β-catenin signaling pathway (2023-04-02)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：5.4
引用產品： LX-2 細胞
-
Liuwei Wuling Tablet relieves the inflammatory transformation of hepatocellular carcinoma by inhibiting the PI3K/AKT/NF-κB signalling pathway (2023-11-11)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：5.4
-
Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death (2023-11-26)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：5.4
-
PRDM16 from hepatic stellate cells-derived extracellular vesicles promotes hepatocellular carcinoma progression (2023-11-15)
期刊：American Journal of Cancer Research
DOI：PMID:38058806
影響因子 ：5.3
-
Aucubin inhibits hepatic stellate cell activation through stimulating Nrf2/Smad7 axis (2023-08-20)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.176002
影響因子 ：5.0
引用產品： LX-2 細胞
-
HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression (2023-06-01)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2023.110741
影響因子 ：4.8
-
Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment (2023-06-26)
期刊：Frontiers in Oncology
影響因子 ：4.7
引用產品： Hep G2 細胞 , SK-Hep-1 細胞 , HuH-1 細胞 , LX-2 細胞
-
Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis (2023-04-06)
期刊：Pharmaceuticals
影響因子 ：4.6
-
Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis (2023-10-04)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23629
影響因子 ：4.6
引用產品： LX-2 細胞
-
PTEN Overexpression Alters Autophagy Levels and Slows Sodium Arsenite-Induced Hepatic Stellate Cell Fibrosis (2023-07-03)
期刊：Toxics
影響因子 ：4.6
引用產品： LX-2 細胞
-
Selective Inhibition of Hepatic Stellate Cell and Fibroblast-derived LOXL1 Attenuates BDL and Mdr2-/- Induced Cholestatic Liver Fibrosis (2023-10-24)
期刊：AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
影響因子 ：4.5
引用產品： LX-2 細胞
-
LINC00886 Facilitates Hepatocellular Carcinoma Tumorigenesis by Sequestering microRNA-409-3p and microRNA-214-5p (2023-06-07)
期刊：Journal of Hepatocellular Carcinoma
影響因子 ：4.1
引用產品： LX-2 細胞 , Hep 3B2.1-7 細胞 , HuH-7 細胞
-
Curcumin inhibits the activity and induces apoptosis of activated hepatic stellate cell by suppressing autophagy (2023-11-01)
期刊：JOURNAL OF CELLULAR BIOCHEMISTRY
影響因子 ：4.0
引用產品： LX-2 細胞
-
Exosome-derived miR-23a-5p inhibits HCC proliferation and angiogenesis by regulating PRDX2 expression: MiR-23a-5p/PRDX2 axis in HCC progression. (2023-12-02)
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e23168
影響因子 ：4.0
-
c-Jun-mediated JMJD6 restoration enhances resistance of liver cancer to radiotherapy through the IL-4-activated ERK pathway (2023-04-18)
期刊：CELL BIOLOGY INTERNATIONAL
影響因子 ：3.9
引用產品： LX-2 細胞 , MHCC97-L 細胞 , HuH-7 細胞
-
Kinetin inhibits hepatic stellate cell activation and induces apoptosis via interactions with the TGF-β1/Smad signaling pathway (2023-08-12)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116655
影響因子 ：3.8
引用產品： LX-2 細胞
-
Proanthocyanidin A2 attenuates the activation of hepatic stellate cells by activating the PPAR-γ signalling pathway (2023-08-24)
期刊：AUTOIMMUNITY
DOI：10.1080/08916934.2023.2250101
影響因子 ：3.5
引用產品： LX-2 細胞
-
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation (2023-05-14)
期刊：Transplantation and Cellular Therapy
DOI：10.1016/j.jtct.2023.05.009
影響因子 ：3.2
-
Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis (2023-02-22)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2023.02.048
影響因子 ：3.1
引用產品： LX-2 細胞
-
F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway (2023-04-17)
期刊：Open Medicine
影響因子 ：2.1
引用產品： LX-2 細胞
-
Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-β)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis (2023-01-17)
期刊：HISTOLOGY AND HISTOPATHOLOGY
影響因子 ：2.0
引用產品： LX-2 細胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清 , 青霉素-鏈霉素溶液 (雙抗)，100×
-
miR-140-5p attenuates hepatic fibrosis by directly targeting TGFβR1 (2023-06-14)
期刊：SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
DOI：10.1080/00365521.2023.2223735
影響因子 ：1.9
引用產品： LX-2 細胞
-
SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis (2023-06-25)
期刊：Biomolecules and Biomedicine
影響因子 ：
-
Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway (2022-12-20)
期刊：METABOLISM-CLINICAL AND EXPERIMENTAL
DOI：10.1016/j.metabol.2022.155380
影響因子 ：13.9
引用產品： HL-7702 [L-02; LO2] 細胞 , LX-2 細胞
-
Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway (2022-02-21)
期刊：Pharmacological Research
DOI：10.1016/j.phrs.2022.106139
影響因子 ：10.3
引用產品： LX-2 細胞
-
Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence (2022-12-02)
期刊：PHARMACOLOGICAL RESEARCH
DOI：10.1016/j.phrs.2022.106590
影響因子 ：10.3
引用產品： LX-2 細胞
-
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway (2022-09-07)
期刊：BRITISH JOURNAL OF PHARMACOLOGY
影響因子 ：9.5
引用產品： LX-2 細胞
-
Preparation of Betulinic Acid Galactosylated Chitosan Nanoparticles and Their Effect on Liver Fibrosis (2022-09-14)
期刊：International Journal of Nanomedicine
影響因子 ：7.0
引用產品： Hep G2 細胞 , LX-2 細胞 , HL-7702 [L-02; LO2] 細胞
-
Hastatoside attenuatescarbon tetrachloride-induced liver fibrosis by targeting glycogen synthase kinase-3β (2022-12-07)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2022.154585
影響因子 ：6.7
引用產品： LX-2 細胞
-
Hepatic stellate cell‐released CXCL1 aggravates HCC malignant behaviors through the MIR4435‐2HG/miR‐506‐3p/TGFB1 axis (2022-12-04)
期刊：CANCER SCIENCE
影響因子 ：6.5
引用產品： Hep 3B2.1-7 細胞 , LX-2 細胞
-
Screening of anti-liver fibrosis peptides from turtle shell protein using two-enzyme hydrolysis by molecular docking (2022-12-23)
期刊：Food & Function
影響因子 ：6.3
引用產品： LX-2 細胞
-
Coprinus comatus polysaccharides ameliorated carbon tetrachloride-induced liver fibrosis through modulating inflammation and apoptosis (2022-09-22)
期刊：Food & Function
影響因子 ：6.3
引用產品： LX-2 細胞
-
Aucubin ameliorates liver fibrosis and hepatic stellate cells activation in diabetic mice via inhibiting ER stress-mediated IRE1α/TXNIP/NLRP3 inflammasome through NOX4/ROS pathway (2022-08-10)
期刊：CHEMICO-BIOLOGICAL INTERACTIONS
影響因子 ：5.2
引用產品： LX-2 細胞
-
Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4 (2022-02-24)
期刊：Bioengineered
DOI：10.1080/21655979.2021.2023799
影響因子 ：4.9
-
Long noncoding RNA HULC regulates the NF-κB pathway and represents a promising prognostic biomarker in liver cancer (2022-10-10)
期刊：Cancer Medicine
影響因子 ：4.7
引用產品： Hep G2 細胞 , Hep 3B2.1-7 細胞 , HuH-7 細胞 , LX-2 細胞
-
Extracellular vesicles derived from cancer-associated fibroblasts carry tumor-promotive microRNA-1228-3p to enhance the resistance of hepatocellular carcinoma cells to sorafenib (2022-11-23)
期刊：Human Cell
DOI：10.1007/s13577-022-00800-7
影響因子 ：4.4
引用產品： LX-2 細胞 , 293T [HEK-293T] 細胞
-
Monocyte-derived immature dendritic cells negatively regulate hepatic stellate cells in vitro by secreting IL-10 (2022-12-21)
期刊：IMMUNOBIOLOGY
DOI：10.1016/j.imbio.2022.152315
影響因子 ：3.2
引用產品： LX-2 細胞
-
Collagen-binding fibroblast growth factor ameliorates liver fibrosis in murine bile duct ligation injury (2022-08-15)
期刊：JOURNAL OF BIOMATERIALS APPLICATIONS
影響因子 ：2.7
引用產品： LX-2 細胞
-
3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway (2021-12-20)
期刊：Journal Of Nanobiotechnology
DOI：10.1186/s12951-021-01138-2
影響因子 ：10.2
引用產品： LX-2 細胞
-
HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis (2021-10-15)
期刊：BMC Medicine
DOI：10.1186/s12916-021-02085-3
影響因子 ：9.3
引用產品： LX-2 細胞
-
Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis (2021-01-16)
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.01.007
影響因子 ：8.8
引用產品： LX-2 細胞
-
CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment (2021-08-02)
期刊：Frontiers in Cell and Developmental Biology
影響因子 ：5.5
-
Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis (2021-11-15)
期刊：Molecules
影響因子 ：4.6
-
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway (2021-08-21)
期刊：Drug Design Development and Therapy
影響因子 ：4.3
引用產品： LX-2 細胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清
-
PM2.5 promotes Drp1-mediated mitophagy to induce hepatic stellate cell activation and hepatic fibrosis via regulating miR-411 (2021-09-08)
期刊：Experimental Cell Research
DOI：10.1016/j.yexcr.2021.112828
影響因子 ：4.2
引用產品： LX-2 細胞
-
Discovery of catalytic-site-fluorescent probes for tracing phosphodiesterase 5 in living cells (2021-10-04)
期刊：RSC Advances
影響因子 ：3.9
引用產品： LX-2 細胞
-
MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression (2021-11-25)
期刊：Toxicology Letters
DOI：10.1016/j.toxlet.2021.11.014
影響因子 ：3.5
引用產品： LX-2 細胞
-
miR221 regulates TGF-β1-induced HSC activation through inhibiting autophagy by directly targeting LAMP2 (2021-09-09)
期刊：Molecular Medicine Reports
影響因子 ：3.4
引用產品： LX-2 細胞
-
Knockdown of TRIM15 inhibits the activation of hepatic stellate cells (2021-06-17)
期刊：Journal Of Molecular Histology
DOI：10.1007/s10735-021-09997-7
影響因子 ：3.2
引用產品： LX-2 細胞
-
Identification of miRNA-target gene regulatory networks in liver fibrosis based on bioinformatics analysis (2021-08-06)
期刊：PeerJ
影響因子 ：2.7
引用產品： LX-2 細胞
-
Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway (2020-06-05)
期刊：Signal Transduction and Targeted Therapy
影響因子 ：39.3
引用產品： LX-2 細胞
-
Fe (III)@TA@IGF-2 microspheres loaded hydrogel for liver injury treatment (2020-04-28)
期刊：International Journal Of Biological Macromolecules
DOI：10.1016/j.ijbiomac.2020.04.206
影響因子 ：8.2
引用產品： LX-2 細胞
-
Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs (2020-03-30)
期刊：Life Sciences
影響因子 ：6.1
-
The mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation (2020-03-27)
期刊：Bioscience Reports
影響因子 ：4.0
引用產品： LX-2 細胞
-
Structures and In Vitro Antihepatic Fibrosis Activities of Prenylated Dihydrostilbenes and Flavonoids from Glycyrrhiza uralensis Leaves (2019-04-16)
期刊：Journal Of Food Science
影響因子 ：3.9
引用產品： LX-2 細胞
-
Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine?functionalized magnetic iron oxide nanoparticles on LX?2 cells (2019-11-20)
期刊：Molecular Medicine Reports
影響因子 ：3.4
引用產品： LX-2 細胞
-
Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH (2019-12-20)
期刊：PeerJ
影響因子 ：3.1
引用產品： LX-2 細胞
-
Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis (2019-03-22)
期刊：PeerJ
影響因子 ：2.7
引用產品： LX-2 細胞
-
Hyperoside protects against heart failure-induced liver fibrosis in rats (2019-07-26)
期刊：Acta Histochemica
DOI：10.1016/j.acthis.2019.07.005
影響因子 ：2.5
引用產品： LX-2 細胞
-
MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression (2018-06-18)
期刊：Cell Death & Disease
影響因子 ：9.0
引用產品： LX-2 細胞
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