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產(chǎn)品概述
| 名稱 | U-937 (人組織細胞淋巴瘤細胞) (STR鑒定正確) |
| 別稱 | U937; U 937 |
| 種屬 | 人 |
| 生長特性 | 懸浮細胞 |
| 細胞形態(tài) | 單核細胞 |
| 凍存條件 | 凍存液：55% 基礎培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 5×10^5-1×10^6cells/mL |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項 | 該細胞為懸浮細胞，請注意離心收集細胞懸液；請勿直接倒掉細胞培養(yǎng)液。 |
| 背景描述 | U-937細胞是由Sundstrom和Nilsson于1974年建立，取材于患組織細胞淋巴瘤病人的胸水。研究表明：U-937細胞能被人混合淋巴細胞培養(yǎng)上清，佛波脂、維生素D3、γ干擾素、腫瘤壞死因子和維甲酸誘導終末單核細胞分化。U-937細胞免疫球蛋白產(chǎn)物和EB病毒表達為陰性；U-937細胞表達Fas抗原且對TNF和抗-Fas抗體敏感。 |
| 年齡（性別） | 男性 |
| 組織來源 | 組織細胞淋巴瘤 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 淋巴瘤細胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~30-60 hours |
| 受體表達情況 | complement (C3) |
| 基因表達情況 | lysozyme; beta-2-microglobulin (beta 2 microglobulin); tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-alpha, TNF alpha), after stimulation with phorbol myristic acid (PMA) |
| 保藏機構 | ATCC; CRL-1593ATCC; CRL-1593.2 DSMZ; ACC-5 ECACC; 85011440 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 12 D2S1338 17,20 D3S1358 16 D5S818 12 D7S820 9,11 D8S1179 12,13 D13S317 10,12 D16S539 12 D18S51 13,14 D19S433 14,16 D21S11 27,29 FGA 22,25 PentaD 12,13 PentaE 13 TH01 6,9.3 TPOX 8,11 vWA 14,15 D6S1043 12,18 D12S391 17,18 D2S441 10 -
STR鑒定圖
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參考文獻
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PLIN2 Promotes Lipid Accumulation in Ascites-Associated Macrophages and Ovarian Cancer Progression by HIF1α/SPP1 Signaling (2025-02-07)
期刊：Advanced Science
影響因子 ：14.3
引用產(chǎn)品： U-937 細胞 , NIH:OVCAR-3 [OVCAR3] 細胞 , 特級胎牛血清 , 重組人胰島素溶液（10 mg/mL） , SK-OV-3 細胞 , McCoy's 5A 培養(yǎng)基 , THP-1 細胞
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Hepatoma cell-derived exosomal SNORD52 mediates M2 macrophage polarization by activating the JAK2/STAT6 pathway (2025-01-13)
期刊：Discover Oncology
DOI：10.1007/s12672-024-01700-y
影響因子 ：2.8
引用產(chǎn)品： U-937 細胞
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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues (2024-02-15)
期刊：Protein & Cell
影響因子 ：21.1
引用產(chǎn)品： U-937 細胞 , 特級胎牛血清 , 青霉素-鏈霉素溶液 (雙抗)，100×
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Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression (2024-06-19)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.06.014
影響因子 ：7.1
引用產(chǎn)品： HT-1080 [HT1080] 細胞 , BxPC-3 細胞 , HuH-7 細胞 , U-937 細胞 , SU-DHL-4 細胞 , Jurkat, Clone E6-1 細胞 , NB4 細胞 , Caov-3 細胞
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Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis (2024-08-24)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.4c00949
影響因子 ：6.8
引用產(chǎn)品： HT-29 細胞 , U-937 細胞 , J774A.1 細胞 , NCTC clone 929 [L cell, L-929] 細胞
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Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy (2024-03-09)
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2024.116304
影響因子 ：6.7
引用產(chǎn)品： U-937 細胞
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High-glucose conditions attenuate the response of macrophages to Legionella pneumophila infection by inhibiting NOD1 and MAPK signaling (2024-05-15)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112254
影響因子 ：5.6
引用產(chǎn)品： U-937 細胞
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A potent dual inhibitor targeting COX-2 and HDAC of acute myeloid leukemia cells (2024-10-31)
期刊：MOLECULAR DIVERSITY
DOI：10.1007/s11030-024-11000-w
影響因子 ：3.9
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization (2024-04-15)
期刊：World Journal of Gastrointestinal Oncology
影響因子 ：3.0
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Correlating gene expression levels with transcription factor binding sites facilitates identification of key transcription factors from transcriptome data (2024-11-29)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2024.1511456
影響因子 ：2.8
引用產(chǎn)品： MOLM-13 細胞 , HL-60 細胞 , U-937 細胞 , OCI-AML-3 細胞
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Gastrodin Suppresses the Progression of Atherosclerosis and Vascular Inflammation by Regulating TLR4/NF‐κB Pathway (2024-01-25)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01218-8
影響因子 ：2.6
引用產(chǎn)品： U-937 細胞 , 人臍靜脈內(nèi)皮細胞
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Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2 (2024-04-10)
期刊：Discover Oncology
DOI：10.1007/s12672-024-00963-9
影響因子 ：2.2
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NAP1L5 promotes epithelial–mesenchymal transition by regulating PEG10 expression in acute myeloid leukaemia (2024-11-13)
期刊：LEUKEMIA RESEARCH
DOI：10.1016/j.leukres.2024.107623
影響因子 ：2.1
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Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia (2024-03-04)
期刊：Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
DOI：10.1007/s43450-023-00502-7
影響因子 ：1.6
引用產(chǎn)品： U-937 細胞
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miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis (2023-11-16)
期刊：ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
DOI：10.1161/ATVBAHA.123.319776
影響因子 ：8.7
引用產(chǎn)品： U-937 細胞
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Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy (2023-08-22)
期刊：SENSORS AND ACTUATORS B-CHEMICAL
影響因子 ：8.4
引用產(chǎn)品： K-562 [K562] 細胞 , U-937 細胞 , Raji 細胞 , Jurkat, Clone E6-1 細胞 , K-562 [K562]細胞專用培養(yǎng)基 , U-937細胞專用培養(yǎng)基 , Raji細胞專用培養(yǎng)基 , Jurkat, Clone E6-1細胞專用培養(yǎng)基
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Discovery of novel 5-phenylpyrazol receptor interacting protein 1(RIP1) kinase inhibitors as anti-necroptosis agents by combining virtual screening and in vitro and in vivo experimental evaluations (2023-11-11)
期刊：BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2023.106964
影響因子 ：5.1
引用產(chǎn)品： U-937 細胞
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Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells: hsa_circ_0013880/USP32/Rap1b in acute myeloid leukemia (2023-03-23)
期刊：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
影響因子 ：3.7
引用產(chǎn)品： HL-60 細胞 , U-937 細胞 , IMDM 培養(yǎng)基
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Scaffold hopping derived novel benzoxazepinone RIPK1 inhibitors as anti-necroptosis agents (2023-06-20)
期刊：BIOORGANIC & MEDICINAL CHEMISTRY
影響因子 ：3.5
引用產(chǎn)品： U-937 細胞
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration (2023-03-23)
期刊：Oncologie
DOI：10.1515/oncologie-2022-1002
影響因子 ：0.9
引用產(chǎn)品： U-937 細胞 , Jurkat, Clone E6-1 細胞 , A549 [A-549] 細胞 , A-375 細胞 , Hep G2 細胞 , U-87 MG 細胞
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Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway (2022-10-18)
期刊：Molecular Metabolism
DOI：10.1016/j.molmet.2022.101617
影響因子 ：8.6
引用產(chǎn)品： U-937 細胞
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RAB3D/MDM2/β-catenin/c-MYC axis exacerbates the malignant behaviors of acute myeloid leukemia cells in vitro and in vivo (2022-10-24)
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00549-z
影響因子 ：5.9
引用產(chǎn)品： HL-60 細胞 , U-937 細胞 , Kasumi-1 細胞 , KG-1 細胞
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Macrophage-derived exosomal miR-4532 promotes endothelial cells injury by targeting SP1 and NF-κB P65 signalling activation (2022-09-07)
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影響因子 ：5.3
引用產(chǎn)品： 人臍靜脈內(nèi)皮細胞 , U-937 細胞 , 293T [HEK-293T] 細胞
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Matrisome provides a supportive microenvironment for oral squamous cell carcinoma progression (2021-12-16)
期刊：Journal of Proteomics
DOI：10.1016/j.jprot.2021.104454
影響因子 ：3.3
引用產(chǎn)品： U-937 細胞
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An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy (2020-08-20)
期刊：Journal for ImmunoTherapy of Cancer
影響因子 ：10.9
引用產(chǎn)品： U-937 細胞
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MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha (2019-10-01)
期刊：Annals of Hepatology
DOI：10.1016/j.aohep.2019.08.007
影響因子 ：3.8
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miR‐129‐2‐3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population (2018-11-29)
期刊：Journal Of Cellular And Molecular Medicine
影響因子 ：5.3
引用產(chǎn)品： THP-1 細胞 , U-937 細胞 , 293T [HEK-293T] 細胞 , PUMC-HUVEC-T1
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Identification of Blood Let-7e-5p as a Biomarker for Ischemic Stroke (2016-10-24)
期刊：PLoS One
DOI：10.1371/journal.pone.0163951
影響因子 ：3.7
引用產(chǎn)品： U-937 細胞
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