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產(chǎn)品概述
名稱 | A-431 (人表皮癌細胞) (STR鑒定正確) |
別稱 | A431; A431/P |
種屬 | 人 |
生長特性 | 貼壁細胞 |
細胞形態(tài) | 上皮細胞樣 |
凍存條件 | 凍存液:55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度:液氮 |
培養(yǎng)方案A(默認) |
培養(yǎng)條件:
氣相:空氣,95%;CO2,5%, 溫度:37℃
|
推薦傳代比例 | 1:3-1:6 |
推薦換液頻率 | 2-3次/周 |
注意事項 | 1.細胞成片生長,生長速度緩慢;2.細胞貼壁很牢、較難消化;如有必要,可分次消化。 |
背景描述 | 皮膚癌細胞株A-431源自一位85歲女性,是由D·J·Giard等人建立的一系列細胞株中的一株。A-431細胞在抗胸腺細胞球蛋白、血清處理的NIH瑞士小鼠中形成類似于惡性黑素瘤快速增長的皮下腫瘤,在普通成纖維細胞和瓊脂上形成克隆。A-431細胞是一個超三倍體人細胞株。 |
年齡(性別) | 女性;85歲 |
組織來源 | 皮膚;上皮;皮膚癌 |
細胞類型 | 腫瘤細胞 |
腫瘤類型 | 其它腫瘤細胞 |
生物安全等級 | BSL-1 |
倍增時間 | ~80-100 hours |
致瘤性 | Yes, forms rapidly growing subcutaneous tumors in immunosuppressed mice and colonies in soft agar. |
保藏機構(gòu) | ATCC; CRL-1555 ATCC; CRL-7907BCRC; 60161 BCRJ; 0032 DSMZ; ACC-91 ECACC; 85090402 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 11,12 D2S1338 17,20 D3S1358 14 D5S818 12,13 D7S820 10 D8S1179 13 D13S317 9,13 D16S539 12,14 D18S51 13,17 D19S433 15,15.2 D21S11 28,30 FGA 20 PentaD 9,11 PentaE 12,13 TH01 9 TPOX 11 vWA 15,17 D6S1043 12,18 D12S391 18,23 D2S441 11.3,15 -
STR鑒定圖
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參考文獻
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METTL1 coordinates cutaneous squamous cell carcinoma progression via the m7G modification of the ATF4 mRNA (2025-01-27)
期刊:Cell Death Discovery
DOI:10.1038/s41420-025-02304-3
影響因子 :6.1
引用產(chǎn)品: HSC-1 細胞 , A-431 細胞 , Hacat 細胞
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Self-Assembly of Erlotinib-Platinum(II) Complexes for Epidermal Growth Factor Receptor-Targeted Photodynamic Therapy (2024-01-06)
期刊:JOURNAL OF MEDICINAL CHEMISTRY
DOI:10.1021/acs.jmedchem.3c01889
影響因子 :7.3
引用產(chǎn)品: A549 [A-549] 細胞 , A549/DDP 細胞 , A549/Tax 細胞 , A-431 細胞 , MRC-5 細胞
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ATP Citrate Lyase is a General Tumour Biomarker and Contributes to the Development of Cutaneous Squamous Cell Carcinoma (2024-04-08)
期刊:ACTA DERMATO-VENEREOLOGICA
影響因子 :3.6
引用產(chǎn)品: A-431 細胞
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NR5A2 promotes malignancy progression and mediates the effect of cisplatin in cutaneous squamous cell carcinoma (2024-02-15)
期刊:Immunity Inflammation and Disease
影響因子 :3.2
引用產(chǎn)品: Hacat 細胞 , A-431 細胞 , Colo-16 細胞 , SCL-1 細胞 , SCL-2 細胞 , HSC-5 細胞
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Exosome-tuned MOF signal amplifier boosting tumor exosome phenotyping with high-affinity nanostars (2023-11-11)
期刊:BIOSENSORS & BIOELECTRONICS
DOI:10.1016/j.bios.2023.115828
影響因子 :12.6
引用產(chǎn)品: MCF7 [MCF-7] 細胞 , RAW 264.7 細胞 , Hela 細胞 , A549 [A-549] 細胞 , Hep G2 細胞 , A-431 細胞 , HL-7702 [L-02; LO2] 細胞 , SK-BR-3 [SKBR3] 細胞 , MDA-MB-231 細胞 , MCF 10A 細胞
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UBE2C promotes malignancy of cutaneous squamous cell carcinoma (2023-11-16)
期刊:SKIN RESEARCH AND TECHNOLOGY
影響因子 :2.2
引用產(chǎn)品: A-431 細胞
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Near-Infrared Light-Activated Oxygen Generator a Multidynamic Photo-Nanoplatform for Effective Anti-Cutaneous Squamous Cell Carcinoma Treatment (2022-11-28)
期刊:International Journal of Nanomedicine
影響因子 :7.0
引用產(chǎn)品: A-431 細胞
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The Fgl2 interaction with Tyrobp promotes the proliferation of cutaneous squamous cell carcinoma by regulating ERK-dependent autophagy (2022-01-01)
期刊:International Journal of Medical Sciences
影響因子 :3.6
引用產(chǎn)品: A-431 細胞
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Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN (2022-11-11)
期刊:KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
影響因子 :3.0
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Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma (2022-02-10)
期刊:PeerJ
影響因子 :2.7
引用產(chǎn)品: A-431 細胞
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Artesunate restrains the malignant progression of human cutaneous squamous cell carcinoma cells via the suppression of the PI3K/AKT pathway (2022-03-19)
期刊:Tissue & Cell
DOI:10.1016/j.tice.2022.101789
影響因子 :2.6
引用產(chǎn)品: A-431 細胞 , DMEM高糖完全培養(yǎng)基 (含10%FBS)
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Regulatory role of methionine enkephalin in myeloid-derived suppressor cells and macrophages in human cutaneous squamous cell carcinoma (2021-07-23)
期刊:International Immunopharmacology
DOI:10.1016/j.intimp.2021.107996
影響因子 :5.6
引用產(chǎn)品: A-431 細胞
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Novel 4-anilinoquinazoline derivatives featuring an 1-adamantylmoiety as potent EGFR inhibitors with enhanced activity againstNSCLC cell lines (2016-01-26)
期刊:European Journal of Medicinal Chemistry
DOI:10.1016/j.ejmech.2016.01.045
影響因子 :6.7
引用產(chǎn)品: A-431 細胞 , HCC827 細胞 , NCI-H1975 細胞 , A549 [A-549] 細胞 , MCF7 [MCF-7] 細胞
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