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Caki-1 (人腎透明細(xì)胞癌皮膚轉(zhuǎn)移細(xì)胞) (STR鑒定正確)
貨號(hào)：CL-0052
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價(jià)格： ￥1600
生長培養(yǎng)基：McCoy's 5A＋10% FBS＋1% P/S
產(chǎn)品概述
| 名稱 | Caki-1 (人腎透明細(xì)胞癌皮膚轉(zhuǎn)移細(xì)胞) (STR鑒定正確) |
| 別稱 | CAKI-1; CaKi-1; caki-1; CAKI.1; CAKI 1; CAKI1; Caki1 |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | Caki-1細(xì)胞的超微結(jié)構(gòu)中包含許多微絨毛、少許微絲、許多小線粒體、充分發(fā)育的高爾基體、內(nèi)質(zhì)網(wǎng)、許多脂滴和多層體，次級(jí)溶酶體；目前，沒有在Caki-1細(xì)胞內(nèi)發(fā)現(xiàn)病毒顆粒。 |
| 年齡（性別） | 男性；49歲 |
| 組織來源 | 腎透明細(xì)胞癌皮膚轉(zhuǎn)移 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 腎癌細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 倍增時(shí)間 | ~40-60 hours |
| 致瘤性 | Yes, in nude mice; forms clear cell carcinoma in nude mice consistent with renal primary; also forms tumors in steroid treated hamsters. |
| 抗原表達(dá)情況 | Blood Type O; Rh-; HLA A9, B12, Bw35 |
| 保藏機(jī)構(gòu) | ATCC; HTB-46 DSMZ; ACC-142DSMZ; ACC-731 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 10,11 D2S1338 17,19 D3S1358 17 D5S818 11,12 D7S820 8,12 D8S1179 12,14 D13S317 11,12 D16S539 12 D18S51 14 D19S433 14 D21S11 28,30 FGA 26 PentaD 11,12 PentaE 11,22 TH01 6,8 TPOX 8,11 vWA 15,17 D6S1043 11,12 D12S391 15,17 D2S441 12,14 -
STR鑒定圖
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參考文獻(xiàn)
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HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY (2025-01-01)
期刊：International Journal of Biological Sciences
影響因子 ：8.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , A-498 細(xì)胞 , ACHN 細(xì)胞 , Caki-1 細(xì)胞 , HK-2 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target (2025-02-25)
期刊：CANCER IMMUNOLOGY IMMUNOTHERAPY
DOI：10.1007/s00262-025-03967-8
影響因子 ：4.6
引用產(chǎn)品： Caki-1 細(xì)胞 , OS-RC-2 細(xì)胞 , A-498 細(xì)胞
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Identifying ADME-related gene signature for immune landscape and prognosis in KIRC by single-cell and spatial transcriptome analysis (2025-01-08)
期刊：Scientific Reports
DOI：10.1038/s41598-024-84018-7
影響因子 ：3.8
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , HK-2 細(xì)胞
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TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3 (2024-05-22)
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06741-3
影響因子 ：9.0
引用產(chǎn)品： DMEM高糖 培養(yǎng)基 , McCoy's 5A 培養(yǎng)基 , MEM 培養(yǎng)基 , ACHN 細(xì)胞 , Caki-2 細(xì)胞 , RPMI-1640 培養(yǎng)基 , Caki-1 細(xì)胞 , 769-P 細(xì)胞
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Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells (2024-03-30)
期刊：APOPTOSIS
DOI：10.1007/s10495-024-01953-6
影響因子 ：7.2
引用產(chǎn)品： HK-2 細(xì)胞 , Caki-1 細(xì)胞 , 769-P 細(xì)胞 , 786-O [786-0] 細(xì)胞 , SW839 細(xì)胞
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CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression (2024-11-28)
期刊：CELLULAR AND MOLECULAR LIFE SCIENCES
DOI：10.1007/s00018-024-05504-9
影響因子 ：6.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , 769-P 細(xì)胞 , HK-2 細(xì)胞 , ACHN 細(xì)胞
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Selective expansion of renal cancer stem cells using microfluidic single-cell culture arrays for anticancer drug testing (2024-02-01)
期刊：LAB ON A CHIP
影響因子 ：6.1
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , ACHN 細(xì)胞
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TRIM26 inhibits clear cell renal cell carcinoma progression through destabilizing ETK and thus inactivation of AKT/mTOR signaling (2024-05-21)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-05273-w
影響因子 ：6.1
引用產(chǎn)品： Caki-1 細(xì)胞 , OS-RC-2 細(xì)胞
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Disulfidptosis-associated LncRNA signature predicts prognosis and immune response in kidney renal clear cell carcinoma (2024-08-22)
期刊：Biology Direct
DOI：10.1186/s13062-024-00517-7
影響因子 ：5.7
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , HK-2 細(xì)胞
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TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells (2024-04-08)
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影響因子 ：4.8
引用產(chǎn)品： ACHN 細(xì)胞 , DMEM無糖 培養(yǎng)基 , McCoy's 5A 培養(yǎng)基 , McCoy's 5A無糖 培養(yǎng)基 , MEM無糖（含NEAA） 培養(yǎng)基 , MEM（含NEAA） 培養(yǎng)基 , Caki-1 細(xì)胞
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Low ACADM expression predicts poor prognosis and suppressive tumor microenvironment in clear cell renal cell carcinoma (2024-04-25)
期刊：Scientific Reports
DOI：10.1038/s41598-024-59746-5
影響因子 ：4.6
引用產(chǎn)品： RPMI-1640 培養(yǎng)基 , 786-O [786-0] 細(xì)胞 , ACHN 細(xì)胞 , 769-P 細(xì)胞 , HK-2 細(xì)胞 , Caki-1 細(xì)胞 , McCoy's 5A 培養(yǎng)基 , MEM（含NEAA） 培養(yǎng)基
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Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression (2024-09-02)
期刊：CANCER SCIENCE
影響因子 ：4.5
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , THP-1 細(xì)胞
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Crosstalk of disulfidptosis-related subtypes identifying a prognostic signature to improve prognosis and immunotherapy responses of clear cell renal cell carcinoma patients (2024-04-26)
期刊：BMC GENOMICS
DOI：10.1186/s12864-024-10307-0
影響因子 ：4.4
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , HK-2 細(xì)胞 , ACHN 細(xì)胞
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC (2024-03-21)
期刊：GENE
DOI：10.1016/j.gene.2024.148403
影響因子 ：3.5
引用產(chǎn)品： HK-2 細(xì)胞 , ACHN 細(xì)胞 , A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , Caki-1 細(xì)胞 , RPMI-1640 培養(yǎng)基 , MEM 培養(yǎng)基
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DLX5 Promotes Radioresistance in Renal Cell Carcinoma by Upregulating c-Myc Expression (2024-11-26)
期刊：Frontiers in Bioscience-Landmark
影響因子 ：3.3
引用產(chǎn)品： 特級(jí)胎牛血清 , McCoy's 5A 培養(yǎng)基 , A-498 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基 , 786-O [786-0] 細(xì)胞 , 青霉素-鏈霉素溶液（雙抗），100× , Caki-1 細(xì)胞 , RPMI-1640 培養(yǎng)基 , HK-2 細(xì)胞
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A Model to Predict Prognosis of Renal Cell Clear Cell Carcinoma Based on 3 Angiogenesis-related Long Non-coding RNAs (2024-04-29)
期刊：Journal of Cancer
影響因子 ：3.3
引用產(chǎn)品： HK-2 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , RCC-JF 細(xì)胞
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KAT7 Suppresses Tumorigenesis in Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating Cell Cycle and Ferroptosis Sensitivity (2024-07-02)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.114149
影響因子 ：3.3
引用產(chǎn)品： ACHN 細(xì)胞 , Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-2 細(xì)胞
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Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma (2024-11-29)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2024.117181
影響因子 ：3.3
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-2 細(xì)胞 , HK-2 細(xì)胞 , 769-P 細(xì)胞
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Exploring necrosis-associated mitochondrial gene signatures: revealing their role in prognosis and immunotherapy of renal clear cell carcinoma (2024-07-18)
期刊：CLINICAL AND EXPERIMENTAL MEDICINE
DOI：10.1007/s10238-024-01426-9
影響因子 ：3.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , ACHN 細(xì)胞 , Caki-1 細(xì)胞 , HK-2 細(xì)胞
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ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B (2024-06-14)
期刊：GENE
DOI：10.1016/j.gene.2024.148702
影響因子 ：2.6
引用產(chǎn)品： OS-RC-2 細(xì)胞 , Caki-1 細(xì)胞 , HK-2 細(xì)胞 , THP-1 細(xì)胞
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PLAUR facilitates the progression of clear cell renal cell carcinoma by activating the PI3K/AKT/mTOR signaling pathway (2024-06-27)
期刊：PeerJ
影響因子 ：2.3
引用產(chǎn)品： Caki-1 細(xì)胞 , ACHN 細(xì)胞 , 769-P 細(xì)胞 , 786-O [786-0] 細(xì)胞 , 293 [HEK-293] 細(xì)胞
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis (2024-05-11)
期刊：Discover Oncology
DOI：10.1007/s12672-024-01018-9
影響因子 ：2.2
引用產(chǎn)品： A-498 細(xì)胞 , Caki-2 細(xì)胞 , Caki-1 細(xì)胞 , 769-P 細(xì)胞 , 293 [HEK-293] 細(xì)胞 , OS-RC-2 細(xì)胞 , 786-O [786-0] 細(xì)胞
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Integrative bioinformatics and in vitro exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma (2024-10-16)
期刊：ONCOLOGY RESEARCH
影響因子 ：2.0
引用產(chǎn)品： Caki-1 細(xì)胞 , OS-RC-2 細(xì)胞 , ACHN 細(xì)胞 , HK-2 細(xì)胞 , 786-O [786-0] 細(xì)胞
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Identifying CDCA3 as a pivotal biomarker for predicting outcomes and immunotherapy efficacy in pan-renal cell carcinoma (2024-09-26)
期刊：Translational Andrology and Urology
影響因子 ：1.9
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞
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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p (2024-05-19)
期刊：GENESIS
影響因子 ：1.5
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , McCoy's 5A 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , A-498 細(xì)胞 , HK-2 細(xì)胞 , RPMI-1640 培養(yǎng)基 , 769-P 細(xì)胞 , Caki-1 細(xì)胞
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming (2023-02-20)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05677-4
影響因子 ：9.0
引用產(chǎn)品： A-498 細(xì)胞 , ACHN 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞
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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma (2023-08-26)
期刊：Computational and Structural Biotechnology Journal
DOI：10.1016/j.csbj.2023.08.023
影響因子 ：6.0
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞
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Establishing a prognostic model based on five starvation-related long non-coding RNAs for clear cell renal cell carcinoma (2023-06-20)
期刊：Aging-US
影響因子 ：5.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , HK-2 細(xì)胞
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LncRNA-encoded Micropeptide ACLY?-?BP drives lipid deposition and cell proliferation in Clear Cell Renal Cell Carcinoma via maintenance of ACLY acetylation (2023-07-06)
期刊：MOLECULAR CANCER RESEARCH
DOI：10.1158/1541-7786.MCR-22-0781
影響因子 ：5.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , 293T [HEK-293T] 細(xì)胞 , ACHN 細(xì)胞 , Caki-1 細(xì)胞
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Identification of the regulatory mechanism of ACE2 in COVID-19–induced kidney damage with systems genetics approach (2023-03-23)
期刊：JOURNAL OF MOLECULAR MEDICINE-JMM
DOI：10.1007/s00109-023-02304-9
影響因子 ：4.7
引用產(chǎn)品： Caki-1 細(xì)胞
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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance (2023-04-08)
期刊：Scientific Reports
DOI：10.1038/s41598-023-27975-9
影響因子 ：4.6
引用產(chǎn)品： HK-2 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , SV-HUC-1 細(xì)胞 , T24 [T-24] 細(xì)胞 , 5637 細(xì)胞 , RWPE-1 細(xì)胞 , PC-3 細(xì)胞 , DU 145 細(xì)胞 , DMEM高糖 培養(yǎng)基 , RPMI-1640 培養(yǎng)基 , Ham's F-12K 培養(yǎng)基 , 人前列腺上皮細(xì)胞完全培養(yǎng)基
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Based on disulfidptosis, revealing the prognostic and immunological characteristics of renal cell carcinoma with tumor thrombus of vena cava and identifying potential therapeutic target AJAP1 (2023-05-29)
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-04877-x
影響因子 ：3.6
引用產(chǎn)品： HK-2 細(xì)胞 , Caki-1 細(xì)胞 , OS-RC-2 細(xì)胞
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P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway (2023-01-02)
期刊：MEDICAL ONCOLOGY
DOI：10.1007/s12032-022-01926-2
影響因子 ：3.4
引用產(chǎn)品： OS-RC-2 細(xì)胞 , 786-O [786-0] 細(xì)胞 , ACHN 細(xì)胞 , 769-P 細(xì)胞 , Caki-1 細(xì)胞
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RUNX1 predicts poor prognosis and correlates with tumor progression in clear cell renal carcinoma (2023-10-12)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.8
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , 青霉素-鏈霉素溶液 (雙抗)，100×
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TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression (2023-10-30)
期刊：PeerJ
影響因子 ：2.7
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞
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Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma (2022-09-30)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1021935
影響因子 ：8.8
引用產(chǎn)品： ACHN 細(xì)胞 , HK-2 細(xì)胞 , Caki-2 細(xì)胞 , A-498 細(xì)胞 , Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , 769-P 細(xì)胞
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Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis (2022-12-25)
期刊：Cancers
影響因子 ：6.6
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , ACHN 細(xì)胞 , Caki-1 細(xì)胞 , 769-P 細(xì)胞 , HK-2 細(xì)胞
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Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis. (2022-09-21)
期刊：Frontiers in Pharmacology
影響因子 ：6.0
引用產(chǎn)品： SV-HUC-1 細(xì)胞 , T24 [T-24] 細(xì)胞 , 5637 細(xì)胞 , HK-2 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , RWPE-1 細(xì)胞 , PC-3 細(xì)胞 , DU 145 細(xì)胞 , Ham's F-12K 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , 人前列腺上皮細(xì)胞完全培養(yǎng)基 , RPMI-1640 培養(yǎng)基
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Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma (2022-01-14)
期刊：Faseb Journal
影響因子 ：4.8
引用產(chǎn)品： OS-RC-2 細(xì)胞 , Caki-1 細(xì)胞
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Pan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma (2022-02-16)
期刊：Journal of Inflammation Research
影響因子 ：4.5
引用產(chǎn)品： Caki-1 細(xì)胞 , 769-P 細(xì)胞 , 786-O [786-0] 細(xì)胞 , ACHN 細(xì)胞 , HK-2 細(xì)胞
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Upregulation of Metallothionein 1?G (MT1G) Negatively Regulates Ferroptosis in Clear Cell Renal Cell Carcinoma by Reducing Glutathione Consumption (2022-09-27)
期刊：Journal of Oncology
影響因子 ：4.5
引用產(chǎn)品： Caki-1 細(xì)胞 , 769-P 細(xì)胞
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The potential of Lycium barbarum miR166a in kidney cancer treatment (2022-12-28)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113455
影響因子 ：4.2
引用產(chǎn)品： Caki-1 細(xì)胞 , ACHN 細(xì)胞 , McCoy's 5A 培養(yǎng)基 , DMEM高糖 培養(yǎng)基
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma (2021-02-19)
期刊：Cell Biology International
影響因子 ：3.9
引用產(chǎn)品： HK-2 細(xì)胞 , A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55 (2020-12-01)
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-020-01744-2
影響因子 ：11.3
引用產(chǎn)品： A-498 細(xì)胞 , Caki-1 細(xì)胞 , Caki-2 細(xì)胞 , 786-O [786-0] 細(xì)胞
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma (2020-05-22)
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-020-03259-x
影響因子 ：3.6
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞
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Sertraline/ICG‐loaded liposome for dual‐modality imaging and effective chemo‐photothermal combination therapy against metastatic clear cell renal cell carcinoma (2020-01-14)
期刊：Chemical Biology & Drug Design
影響因子 ：3.0
引用產(chǎn)品： Caki-1 細(xì)胞
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LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p (2019-11-21)
期刊：Cancer Cell International
影響因子 ：5.8
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , 769-P 細(xì)胞 , 293T [HEK-293T] 細(xì)胞 , Caki-1細(xì)胞專用培養(yǎng)基 , 786-O [786-0]細(xì)胞專用培養(yǎng)基 , 769-P細(xì)胞專用培養(yǎng)基 , 293T [HEK-293T]細(xì)胞專用培養(yǎng)基
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