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A-498 (人腎癌細(xì)胞) (STR鑒定正確)
貨號(hào)：CL-0254
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價(jià)格： ￥1800
生長(zhǎng)培養(yǎng)基：MEM（含NEAA）＋10% FBS＋1% P/S
產(chǎn)品概述
| 名稱 | A-498 (人腎癌細(xì)胞) (STR鑒定正確) |
| 別稱 | A498 |
| 種屬 | 人 |
| 生長(zhǎng)特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長(zhǎng)培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | A-498細(xì)胞是由Aaronson·S建立，源自一位52歲患有腎癌的女性病人。 |
| 年齡（性別） | 女性；52歲 |
| 組織來源 | 腎臟 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 腎癌細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 倍增時(shí)間 | ~60 hours |
| 致瘤性 | Yes, in nude mice; forms undifferentiated carcinoma; also forms tumors in anti thymocyte serum treated newborn mice. |
| 保藏機(jī)構(gòu) | ATCC; CRL-7908ATCC; HTB-44 DSMZ; ACC-55 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 11,12 D2S1338 26 D3S1358 15 D5S818 11,13 D7S820 10,11 D8S1179 13,15 D13S317 12 D16S539 12 D18S51 17 D19S433 12 D21S11 28,32 FGA 18,20 PentaD 9,14 PentaE 10,14 TH01 6,9.3 TPOX 8,11 vWA 18 D6S1043 11 D12S391 21 D2S441 11,14 -
STR鑒定圖
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參考文獻(xiàn)
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HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY (2025-01-01)
期刊：International Journal of Biological Sciences
影響因子 ：8.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , A-498 細(xì)胞 , ACHN 細(xì)胞 , Caki-1 細(xì)胞 , HK-2 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion (2025-01-16)
期刊：Cell Death & Disease
DOI：10.1038/s41419-025-07345-1
影響因子 ：8.1
引用產(chǎn)品： HK-2 細(xì)胞 , ACHN 細(xì)胞 , A-498 細(xì)胞 , 769-P 細(xì)胞 , 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target (2025-02-25)
期刊：CANCER IMMUNOLOGY IMMUNOTHERAPY
DOI：10.1007/s00262-025-03967-8
影響因子 ：4.6
引用產(chǎn)品： Caki-1 細(xì)胞 , OS-RC-2 細(xì)胞 , A-498 細(xì)胞
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PUS1 facilitates cell migration in clear cell renal cell carcinoma through the promotion of mRNA pseudouridylation and the stabilization of the SMOX gene (2025-02-22)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2025.111700
影響因子 ：4.4
引用產(chǎn)品： HK-2 細(xì)胞 , 769-P 細(xì)胞 , 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , OS-RC-2 細(xì)胞
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Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma (2025-01-02)
期刊：Scientific Reports
DOI：10.1038/s41598-024-84834-x
影響因子 ：3.8
引用產(chǎn)品： A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞
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HDAC8 Enhances the Function of HIF-2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC (2024-07-29)
期刊：Advanced Science
影響因子 ：14.3
引用產(chǎn)品： A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞 , ACHN 細(xì)胞
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USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression (2024-10-15)
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-07136-0
影響因子 ：8.1
引用產(chǎn)品： Caki-2 細(xì)胞 , A-498 細(xì)胞 , OS-RC-2 細(xì)胞 , 786-O [786-0] 細(xì)胞
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PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC (2024-10-23)
期刊：ONCOGENE
DOI：10.1038/s41388-024-03198-8
影響因子 ：6.9
引用產(chǎn)品： Ham's F-12K 培養(yǎng)基 , A-498 細(xì)胞 , HUV-EC-C [HUVEC] 細(xì)胞
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A multifunctional antibody fusion protein 57103 targeting CD24, IL-4R, and αvβ3 for treating cancer and regulating the tumor microenvironment (2024-05-17)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2024.116714
影響因子 ：6.9
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , OS-RC-2 細(xì)胞 , Caki-2 細(xì)胞
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CDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors (2024-06-18)
期刊：BRITISH JOURNAL OF CANCER
DOI：10.1038/s41416-024-02750-3
影響因子 ：6.4
引用產(chǎn)品： A-498 細(xì)胞 , HUV-EC-C [HUVEC] 細(xì)胞
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Disulfideptosis-associated lncRNAs reveal features of prognostic, immune escape, tumor mutation, and tumor malignant progression in renal clear cell carcinoma (2024-02-08)
期刊：Aging-US
影響因子 ：5.2
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , A-498 細(xì)胞 , ACHN 細(xì)胞 , HK-2 細(xì)胞
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Integrated Analysis of Single-Cell and Bulk RNA Sequencing Reveals HSD3B7 as a Prognostic Biomarker and Potential Therapeutic Target in ccRCC (2024-12-01)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：4.9
引用產(chǎn)品： A-498 細(xì)胞 , ACHN 細(xì)胞 , 769-P 細(xì)胞 , HK-2 細(xì)胞 , 特級(jí)胎牛血清
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Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-κB pathway (2024-12-03)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.113706
影響因子 ：4.8
引用產(chǎn)品： A-498 細(xì)胞 , THP-1 細(xì)胞 , RAW 264.7 細(xì)胞
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Improved Immunotherapy Outcomes via Cuproptosis Upregulation of HLA-DRA Expression: Promoting the Aggregation of CD4+ and CD8+T Lymphocytes in Clear Cell Renal Cell Carcinoma (2024-05-24)
期刊：Pharmaceuticals
影響因子 ：4.3
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞 , Renca [RenCa] 細(xì)胞
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Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis (2024-01-20)
期刊：Journal of Cancer
影響因子 ：3.9
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞
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SLC11A1 promotes kidney renal clear cell carcinoma (KIRC) progression by remodeling the tumor microenvironment (2024-05-16)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2024.116975
影響因子 ：3.8
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , SW839 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞 , OS-RC-2 細(xì)胞 , THP-1 細(xì)胞
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC (2024-03-21)
期刊：GENE
DOI：10.1016/j.gene.2024.148403
影響因子 ：3.5
引用產(chǎn)品： HK-2 細(xì)胞 , ACHN 細(xì)胞 , A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , Caki-1 細(xì)胞 , RPMI-1640 培養(yǎng)基 , MEM 培養(yǎng)基
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ZBP1 as a prognostic biomarker correlated with cell proliferation in clear cell renal cell carcinoma (2024-10-10)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e39267
影響因子 ：3.4
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞 , ACHN 細(xì)胞 , 769-P 細(xì)胞
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DLX5 Promotes Radioresistance in Renal Cell Carcinoma by Upregulating c-Myc Expression (2024-11-26)
期刊：Frontiers in Bioscience-Landmark
影響因子 ：3.3
引用產(chǎn)品： 特級(jí)胎牛血清 , McCoy's 5A 培養(yǎng)基 , A-498 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基 , 786-O [786-0] 細(xì)胞 , 青霉素-鏈霉素溶液（雙抗），100× , Caki-1 細(xì)胞 , RPMI-1640 培養(yǎng)基 , HK-2 細(xì)胞
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Decreased expression of TXNIP is associated with poor prognosis and immune infiltration in kidney renal clear cell carcinoma (2024-01-12)
期刊：Oncology Letters
影響因子 ：2.9
引用產(chǎn)品： A-498 細(xì)胞 , HK-2 細(xì)胞
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis (2024-05-11)
期刊：Discover Oncology
DOI：10.1007/s12672-024-01018-9
影響因子 ：2.2
引用產(chǎn)品： A-498 細(xì)胞 , Caki-2 細(xì)胞 , Caki-1 細(xì)胞 , 769-P 細(xì)胞 , 293 [HEK-293] 細(xì)胞 , OS-RC-2 細(xì)胞 , 786-O [786-0] 細(xì)胞
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Integration of bulk RNA-seq and single-cell RNA-seq constructs: a cancer-associated fibroblasts-related signature to predict prognosis and therapeutic response in clear cell renal cell carcinoma. (2024-04-15)
期刊：American Journal of Translational Research
影響因子 ：2.2
引用產(chǎn)品： HK-2 細(xì)胞 , A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞
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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p (2024-05-19)
期刊：GENESIS
影響因子 ：1.5
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , McCoy's 5A 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , A-498 細(xì)胞 , HK-2 細(xì)胞 , RPMI-1640 培養(yǎng)基 , 769-P 細(xì)胞 , Caki-1 細(xì)胞
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RNF26 up-regulates PD-L1 to regulate the cancer immune response in ccRCC (2024-09-04)
期刊：BIOCELL
DOI：10.32604/biocell.2024.051747
影響因子 ：0.8
引用產(chǎn)品： Renca [RenCa] 細(xì)胞 , MEM（ATCC改良） 培養(yǎng)基 , A-498 細(xì)胞 , Renca [RenCa]細(xì)胞專用培養(yǎng)基
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ZDHHC2-mediated AGK palmitoylation activates AKT/mTOR signaling to reduce sunitinib sensitivity in renal cell carcinoma (2023-04-20)
期刊：CANCER RESEARCH
DOI：10.1158/0008-5472.CAN-22-3105
影響因子 ：11.2
引用產(chǎn)品： A-498 細(xì)胞 , MEM (含NEAA) 培養(yǎng)基 , Annexin V-FITC染色液
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming (2023-02-20)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05677-4
影響因子 ：9.0
引用產(chǎn)品： A-498 細(xì)胞 , ACHN 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞
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The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis (2023-02-02)
期刊：ONCOGENE
DOI：10.1038/s41388-023-02613-w
影響因子 ：8.0
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , STR鑒定 , MEM (含NEAA) 培養(yǎng)基
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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma (2023-08-26)
期刊：Computational and Structural Biotechnology Journal
DOI：10.1016/j.csbj.2023.08.023
影響因子 ：6.0
引用產(chǎn)品： Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞
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Focusing on the Abnormal Events of NPC1, NPC2, and NPC1L1 in Pan-Cancer and Further Constructing LUAD and KICH Prediction Models (2023-12-18)
期刊：JOURNAL OF PROTEOME RESEARCH
DOI：10.1021/acs.jproteome.3c00655
影響因子 ：4.4
引用產(chǎn)品： A549 [A-549] 細(xì)胞 , NCI-H1299 細(xì)胞 , HK-2 細(xì)胞 , A-498 細(xì)胞 , MEM 培養(yǎng)基 , RPMI-1640 培養(yǎng)基 , Ham's F-12K 培養(yǎng)基
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Construction and Validation of a Novel Cuproptosis-Related Seven-lncRNA Signature to Predict the Outcomes, Immunotherapeutic Responses, and Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma (2023-01-25)
期刊：DISEASE MARKERS
影響因子 ：3.5
引用產(chǎn)品： A-498 細(xì)胞 , OS-RC-2 細(xì)胞
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YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway (2022-08-17)
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02460-9
影響因子 ：12.7
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , STR鑒定 , MEM (含NEAA) 培養(yǎng)基
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Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma (2022-09-30)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1021935
影響因子 ：8.8
引用產(chǎn)品： ACHN 細(xì)胞 , HK-2 細(xì)胞 , Caki-2 細(xì)胞 , A-498 細(xì)胞 , Caki-1 細(xì)胞 , 786-O [786-0] 細(xì)胞 , OS-RC-2 細(xì)胞 , 769-P 細(xì)胞
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WT1 Inhibits Human Renal Carcinoma Cell Proliferation and Induces G2/M Arrest by Upregulating IL-24 Expression (2022-07-23)
期刊：Biomed Research International
影響因子 ：3.2
引用產(chǎn)品： A-498 細(xì)胞
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Identification of a combined lncRNA prognostic signature and knockdown of lncRNA MANCR to inhibit progression of clear cell renal cell carcinoma by bioinformatics analysis (2022-09-01)
期刊：Translational Andrology and Urology
影響因子 ：2.5
引用產(chǎn)品： A-498 細(xì)胞 , ACHN 細(xì)胞 , SN12C 細(xì)胞 , 786-O [786-0] 細(xì)胞 , 769-P 細(xì)胞
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RRM2 Regulates Sensitivity to Sunitinib and PD-1 Blockade in Renal Cancer by Stabilizing ANXA1 and Activating the AKT Pathway (2021-07-28)
期刊：Advanced Science
影響因子 ：15.1
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , Renca [RenCa] 細(xì)胞 , 特級(jí)胎牛血清 , 青霉素-鏈霉素溶液 (雙抗)，100× , MEM (含NEAA) 培養(yǎng)基 , Renca [RenCa]細(xì)胞專用培養(yǎng)基
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Deubiquitylation and stabilization of ARMC5 by ubiquitin-specific processing protease 7 (USP7) are critical for RCC proliferation (2021-02-05)
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影響因子 ：5.3
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , 769-P 細(xì)胞 , A-498 細(xì)胞 , ACHN 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study (2021-11-10)
期刊：Cancer Medicine
影響因子 ：4.0
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma (2021-02-19)
期刊：Cell Biology International
影響因子 ：3.9
引用產(chǎn)品： HK-2 細(xì)胞 , A-498 細(xì)胞 , 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞
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Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma (2021-09-20)
期刊：Pathology Research And Practice
影響因子 ：3.3
引用產(chǎn)品： A-498 細(xì)胞 , Caki-2 細(xì)胞
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APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells (2021-03-17)
期刊：IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
DOI：10.1007/s11626-021-00589-z
影響因子 ：2.1
引用產(chǎn)品： 293T [HEK-293T] 細(xì)胞 , 786-O [786-0] 細(xì)胞 , A-498 細(xì)胞
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55 (2020-12-01)
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-020-01744-2
影響因子 ：11.3
引用產(chǎn)品： A-498 細(xì)胞 , Caki-1 細(xì)胞 , Caki-2 細(xì)胞 , 786-O [786-0] 細(xì)胞
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RETRACTED ARTICLE: Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205 (2020-02-19)
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2020.1725532
影響因子 ：5.8
引用產(chǎn)品： A-498 細(xì)胞 , ACHN 細(xì)胞
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δ‐Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β‐catenin nuclear localization and activating its downstream target genes (2020-01-28)
期刊：Cancer Medicine
影響因子 ：4.0
引用產(chǎn)品： HK-2 細(xì)胞 , A-498 細(xì)胞 , ACHN 細(xì)胞 , 786-O [786-0] 細(xì)胞
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma (2020-05-22)
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-020-03259-x
影響因子 ：3.6
引用產(chǎn)品： 786-O [786-0] 細(xì)胞 , Caki-1 細(xì)胞 , A-498 細(xì)胞 , HK-2 細(xì)胞
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