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產品概述
| 名稱 | C-33 A (人子宮頸癌細胞) (STR鑒定正確) |
| 別稱 | C33A; C33a; C33-A; C-33-A; C-33A; C33 |
| 種屬 | 人 |
| 生長特性 | 貼壁細胞 |
| 細胞形態(tài) | 上皮細胞樣 |
| 凍存條件 | 凍存液：55% 基礎培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:6 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | C-33 A細胞是由N·Auersperg從宮頸癌切片中建立的一系列細胞株中的一株。C-33 A細胞一開始就表現(xiàn)出亞二倍體核型及上皮細胞形態(tài)，C-33 A細胞經連續(xù)傳代可以觀察到核型不穩(wěn)定。C-33 A細胞存在成視網膜細胞瘤蛋白(pRB)，但大小不正常；C-33 A細胞p53表達上調，且有一個273位密碼子的點突變導致Arg→Cys的替換。 |
| 年齡（性別） | 女性；66歲 |
| 組織來源 | 宮頸癌 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 宮頸癌細胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~32-48 hours |
| 保藏機構 | ATCC; HTB-31 ATCC; CRM-HTB-31 BCRC; 60554 BCRJ; 0348 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 12 D2S1338 23,25 D3S1358 16 D5S818 11,12 D7S820 10 D8S1179 10,14 D13S317 13 D16S539 13,14 D18S51 15,18 D19S433 11,13 D21S11 29,30,31 FGA 21,26 PentaD 10 PentaE 6,8 TH01 7,8 TPOX 9 vWA 18,20 D6S1043 9,11,12 D12S391 18,27 D2S441 10,14 -
STR鑒定圖
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參考文獻
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NAD+ Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer (2025-02-23)
期刊：Advanced Science
影響因子 ：14.3
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NSUN7 promotes cervical cancer progression through activation of ErbB signaling pathway (2025-02-15)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-025-01546-9
影響因子 ：3.9
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SOX2 promotes the glycolysis process to accelerate cervical cancer progression by regulating the expression of HK2 (2025-01-16)
期刊：ACTA HISTOCHEMICA
DOI：10.1016/j.acthis.2025.152230
影響因子 ：2.3
引用產品： Hela 細胞 , Ca Ski 細胞 , C-33 A 細胞 , SiHa 細胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清 , 青霉素-鏈霉素溶液（雙抗），100×
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Design of Selective PARP-1 Inhibitors and Antitumor Studies (2024-05-22)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c02460
影響因子 ：7.3
引用產品： SiHa 細胞 , Hela 細胞 , C-33 A 細胞 , SK-OV-3 細胞
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Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1-mediated fatty acid synthesis (2024-10-18)
期刊：Molecular Oncology
影響因子 ：5.0
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Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer (2024-08-24)
期刊：Translational Oncology
DOI：10.1016/j.tranon.2024.102103
影響因子 ：4.5
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HPV16 E6 promoting cervical cancer progression through down-regulation of miR-320a to increase TOP2A expression (2024-01-11)
期刊：Cancer Medicine
影響因子 ：4.0
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APLN promotes the proliferation, migration, and glycolysis of cervical cancer through the PI3K/AKT/mTOR pathway (2024-03-30)
期刊：ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
影響因子 ：3.9
引用產品： C-33 A 細胞 , Hela 細胞 , SiHa 細胞 , Ca Ski 細胞 , ECT1/E6E7 細胞 , 人子宮頸上皮細胞完全培養(yǎng)基
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Norcantharidin inhibits the malignant progression of cervical cancer by inducing endoplasmic reticulum stress (2024-03-07)
期刊：Molecular Medicine Reports
影響因子 ：3.4
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Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway (2024-10-17)
期刊：Cancer Medicine
影響因子 ：2.9
引用產品： SiHa 細胞 , Ca Ski 細胞 , C-33 A 細胞 , 青霉素-鏈霉素溶液（雙抗），100× , MEM 培養(yǎng)基
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N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma (2024-04-28)
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影響因子 ：2.9
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Targeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development (2024-12-31)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2024.102713
影響因子 ：2.7
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Design, Synthesis, and In vitro Anti-cervical Cancer Activity of a Novel MDM2-p53 Inhibitor Based on a Chalcone Scaffold (2024-04-01)
期刊：Anti-Cancer Agents in Medicinal Chemistry
DOI：10.2174/0118715206274066231220071557
影響因子 ：2.6
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METTL14-mediated m6A modification upregulates HOXB13 expression to activate NF-κB and exacerbate cervical cancer progression (2024-11-11)
期刊：Molecular & Cellular Oncology
DOI：10.1080/23723556.2024.2423986
影響因子 ：2.6
引用產品： MEM（含NEAA） 培養(yǎng)基 , C-33 A 細胞 , 青霉素-鏈霉素溶液（雙抗），100× , 特級胎牛血清 , Hela 細胞
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3-Hydroxymorindone from Knoxia roxburghii (Spreng.) M. A. Rau induces ROS-mediated mitochondrial dysfunction cervical cancer cells apoptosis via inhibition of PI3K/AKT/NF-κB signaling pathway (2023-03-11)
期刊：Journal of Functional Foods
影響因子 ：5.6
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Marine Sulfated Polysaccharide PMGS Synergizes with Paclitaxel in Inhibiting Cervical Cancer In Vitro (2023-04-23)
期刊：Marine Drugs
影響因子 ：5.4
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HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition (2023-05-16)
期刊：CELL BIOLOGY INTERNATIONAL
影響因子 ：3.9
引用產品： C-33 A 細胞 , Ca Ski 細胞 , SiHa 細胞 , Hela 細胞 , MEM (含NEAA) 培養(yǎng)基 , 特級胎牛血清 , 青霉素-鏈霉素溶液 (雙抗)，100× , RPMI-1640 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , McCoy's 5A 培養(yǎng)基 , DMEM/F12 培養(yǎng)基
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Increased TCP11 gene expression can inhibit the proliferation, migration and promote apoptosis of cervical cancer cells (2023-09-11)
期刊：BMC CANCER
DOI：10.1186/s12885-023-11129-1
影響因子 ：3.8
引用產品： C-33 A 細胞 , Hacat 細胞
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Characterization of the microenvironment in different immune-metabolism subtypes of cervical cancer with prognostic significance (2023-02-03)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1067666
影響因子 ：3.7
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Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein (2023-11-07)
期刊：Radiation Oncology
DOI：10.1186/s13014-023-02369-3
影響因子 ：3.6
引用產品： SiHa 細胞 , C-33 A 細胞 , Hela 細胞 , 青霉素-鏈霉素溶液 (雙抗)，100×
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SHCBP1 contributes to the proliferation and self?renewal of cervical cancer cells and activation of the NF?κB signaling pathway through EIF5A (2023-04-21)
期刊：Oncology Letters
影響因子 ：2.9
引用產品： SiHa 細胞 , C-33 A 細胞 , Ca Ski 細胞 , DMEM/F12 培養(yǎng)基
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Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer (2023-09-16)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01218-6
影響因子 ：2.9
引用產品： C-33 A 細胞 , Ca Ski 細胞 , Hela S3 細胞 , SiHa 細胞 , 人子宮頸上皮細胞
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BTG2 suppresses the growth and metastasis of cervical squamous cell carcinoma (2023-05-26)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.8
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TRIM21 promotes tumor progression and cancer stemness in cervical squamous cell carcinoma (2023-07-23)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.8
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UCHL1 acts as a prognostic factor and promotes cancer stemness in cervical squamous cell carcinoma (2023-05-26)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：2.8
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Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk (2023-03-23)
期刊：MOLECULAR BIOTECHNOLOGY
DOI：10.1007/s12033-023-00721-2
影響因子 ：2.6
引用產品： SiHa 細胞 , C-33 A 細胞 , 人臍靜脈內皮細胞 , SiHa細胞專用培養(yǎng)基 , C-33 A細胞專用培養(yǎng)基 , 人臍靜脈內皮細胞完全培養(yǎng)基
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Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin β1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer (2023-11-24)
期刊：BIOCHEMICAL GENETICS
DOI：10.1007/s10528-023-10568-6
影響因子 ：2.4
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PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway (2023-01-05)
期刊：HISTOCHEMISTRY AND CELL BIOLOGY
DOI：10.1007/s00418-022-02175-0
影響因子 ：2.3
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MiR-1299 is regulated by KCNQ1OT1 and inhibits cervical cancer progression (2023-10-31)
期刊：CELLULAR AND MOLECULAR BIOLOGY
DOI：10.14715/cmb/2023.69.10.24
影響因子 ：1.6
引用產品： C-33 A 細胞
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CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway (2023-01-01)
期刊：ANNALS OF CLINICAL AND LABORATORY SCIENCE
DOI：PMID:36889763
影響因子 ：0.8
引用產品： MS751 細胞 , Ca Ski 細胞 , SiHa 細胞 , C-33 A 細胞 , Hela 細胞 , MEM 培養(yǎng)基 , RPMI-1640 培養(yǎng)基
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Combined treatment of marizomib and cisplatin modulates cervical cancer growth and invasion and enhances antitumor potential in vitro and in vivo. (2022-08-30)
期刊：Frontiers in Oncology
影響因子 ：5.7
引用產品： C-33 A 細胞
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Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9 (2022-04-07)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2061144
影響因子 ：4.9
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Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer (2022-09-20)
期刊：Frontiers in Genetics
影響因子 ：4.8
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OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway (2022-09-29)
期刊：ONCOLOGY REPORTS
影響因子 ：4.1
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ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma (2022-12-05)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：3.3
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FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma (2022-08-28)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影響因子 ：3.3
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tRNA?derived fragment tRF?Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 (2022-08-09)
期刊：Oncology Letters
影響因子 ：3.1
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hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2 (2022-03-11)
期刊：Journal Of Clinical Laboratory Analysis
影響因子 ：3.1
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Expression of GMFB in High-Grade Cervical Intraepithelial Neoplasia and Its Role in Cervical Cancer (2022-09-22)
期刊：Computational and Mathematical Methods in Medicine
影響因子 ：2.8
引用產品： C-33 A 細胞 , 293T [HEK-293T] 細胞
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CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways (2022-10-25)
期刊：BMC Molecular and Cell Biology
DOI：10.1186/s12860-022-00440-7
影響因子 ：2.8
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Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB (2021-01-19)
期刊：Cellular Oncology
DOI：10.1007/s13402-020-00582-w
影響因子 ：6.6
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USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer (2021-11-25)
期刊：Human Cell
DOI：10.1007/s13577-021-00650-9
影響因子 ：4.3
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The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells (2021-12-24)
期刊：Infectious Agents and Cancer
DOI：10.1186/s13027-021-00409-9
影響因子 ：3.7
引用產品： C-33 A 細胞
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Long non-coding RNA LINC00460 promotes proliferation and inhibits apoptosis of cervical cancer cells by targeting microRNA-503-5p (2020-08-01)
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-020-03853-0
影響因子 ：4.3
引用產品： SiHa 細胞 , C-33 A 細胞 , Hela 細胞 , MEM (含NEAA) 培養(yǎng)基
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Long non?coding RNA AK001903 regulates tumor progression in cervical cancer (2020-11-30)
期刊：Oncology Letters
影響因子 ：2.9
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HPV16+-miRNAs in cervical cancer and the anti-tumor role played by miR-5701 (2019-10-25)
期刊：Journal Of Gene Medicine
DOI：10.1002/jgm.3126
影響因子 ：4.2
引用產品： C-33 A 細胞 , Hela S3 細胞
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Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells (2019-11-30)
期刊：Naunyn-Schmiedebergs Archives of Pharmacology
DOI：10.1007/s00210-019-01772-6
影響因子 ：3.6
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LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p (2019-10-06)
期刊：Clinical And Experimental Pharmacology And Physiology
影響因子 ：2.9
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