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HMC3 (人小膠質(zhì)細(xì)胞) (STR鑒定正確)
貨號：CL-0620
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價格： ￥2500
生長培養(yǎng)基：MEM（含NEAA）＋10% FBS＋1%P/S
產(chǎn)品概述
| 名稱 | HMC3 (人小膠質(zhì)細(xì)胞) (STR鑒定正確) |
| 別稱 | Human Microglia Clone 3 |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:8 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | The HMC3 cell line was established through SV40-dependent immortalization of a human fetal brain-derived primary microglia culture. |
| 年齡（性別） | 胚胎 |
| 組織來源 | 腦組織 |
| 細(xì)胞類型 | 轉(zhuǎn)化細(xì)胞系 |
| 生物安全等級 | BSL-2 |
| 保藏機(jī)構(gòu) | ATCC; CRL-3304 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 10,11 D2S1338 17,25 D3S1358 16,18 D5S818 11,12 D7S820 9,11 D8S1179 13,14 D13S317 11 D16S539 12,13 D18S51 18 D19S433 15,15.2 D21S11 30,31.2 FGA 21,25 PentaD 10,14 PentaE 7,13 TH01 6 TPOX 8,9 vWA 17,19 D6S1043 11 D12S391 16,21 D2S441 11,11.3 -
STR鑒定圖
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參考文獻(xiàn)
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy (2025-01-30)
期刊：Research
影響因子 ：8.5
引用產(chǎn)品： U251 細(xì)胞 , HMC3 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基
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Trace component fishing strategy based on offline two-dimensional liquid chromatography combined with PRDX3-surface plasmon resonance for Uncaria alkaloids (2025-02-20)
期刊：Journal of Pharmaceutical Analysis
DOI：10.1016/j.jpha.2025.101244
影響因子 ：6.1
引用產(chǎn)品： HMC3 細(xì)胞
-
Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia (2024-03-30)
期刊：NEURO-ONCOLOGY
影響因子 ：15.9
引用產(chǎn)品： LN229 [LN-229; LNT-229] 細(xì)胞 , SF126 細(xì)胞 , U-87 MG 細(xì)胞 , HMC3 細(xì)胞 , BV2 細(xì)胞
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Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p (2024-11-29)
期刊：JOURNAL OF HAZARDOUS MATERIALS
DOI：10.1016/j.jhazmat.2024.136719
影響因子 ：12.2
引用產(chǎn)品： HMC3 細(xì)胞 , MEM 培養(yǎng)基
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The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma (2024-09-04)
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-024-03175-9
影響因子 ：11.4
引用產(chǎn)品： BV2 細(xì)胞 , HMC3 細(xì)胞
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Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis (2024-06-28)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2024.06.047
影響因子 ：10.5
引用產(chǎn)品： ARPE-19 細(xì)胞 , HMC3細(xì)胞專用培養(yǎng)基 , HMC3 細(xì)胞
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Understanding the molecular pathway of triclosan-induced ADHD-like behaviour: Involvement of the hnRNPA1-PKM2-STAT3 feedback loop (2024-08-17)
期刊：ENVIRONMENT INTERNATIONAL
DOI：10.1016/j.envint.2024.108966
影響因子 ：10.3
引用產(chǎn)品： HMC3 細(xì)胞 , 青霉素-鏈霉素溶液（雙抗），100× , DMEM高糖 培養(yǎng)基 , 特級胎牛血清
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Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis (2024-10-28)
期刊：Journal of Neuroinflammation
DOI：10.1186/s12974-024-03265-7
影響因子 ：9.3
引用產(chǎn)品： HMC3 細(xì)胞
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Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer’s disease (2024-12-17)
期刊：BRAIN BEHAVIOR AND IMMUNITY
影響因子 ：8.8
引用產(chǎn)品： BV2 細(xì)胞 , HMC3 細(xì)胞
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Remifentanil-induced inflammation in microglial cells: Activation of the PAK4-mediated NF-κB/NLRP3 pathway and onset of hyperalgesia (2024-09-24)
期刊：BRAIN BEHAVIOR AND IMMUNITY
影響因子 ：8.8
引用產(chǎn)品： HMC3 細(xì)胞 , 青霉素-鏈霉素溶液（雙抗），100×
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SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights (2024-04-09)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-05149-z
影響因子 ：7.4
引用產(chǎn)品： THP-1 細(xì)胞 , HMC3 細(xì)胞
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PM2.5 exposure upregulates pro-inflammatory protein expression in human microglial cells via oxidant stress and TLR4/NF-κB pathway (2024-04-23)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2024.116386
影響因子 ：6.8
引用產(chǎn)品： HMC3 細(xì)胞
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Mesenchymal stem cell-derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats (2024-07-29)
期刊：Neural Regeneration Research
DOI：10.4103/NRR.NRR-D-23-02108
影響因子 ：5.9
引用產(chǎn)品： HMC3 細(xì)胞
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Microglia-endothelial cross-talk regulates diabetes-induced retinal vascular dysfunction through remodeling inflammatory microenvironment (2024-02-06)
期刊：iScience
DOI：10.1016/j.isci.2024.109145
影響因子 ：5.8
引用產(chǎn)品： HMC3 細(xì)胞
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Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression (2024-06-11)
期刊：Biology Direct
DOI：10.1186/s13062-024-00487-w
影響因子 ：5.7
引用產(chǎn)品： U251 細(xì)胞 , U-87 MG 細(xì)胞 , HMC3 細(xì)胞
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A New Modulator of Neuroinflammation in Diabetic Retinopathy: USP25 (2024-03-04)
期刊：INFLAMMATION
DOI：10.1007/s10753-024-01991-x
影響因子 ：5.1
引用產(chǎn)品： HMC3 細(xì)胞 , BV2 細(xì)胞
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MST1/2 exerts a pivotal role in inducing neuroinflammation and Coxsackievirus-A10 replication by interacting with innate immunity (2024-04-19)
期刊：Virology Journal
DOI：10.1186/s12985-024-02355-5
影響因子 ：4.8
引用產(chǎn)品： HMC3 細(xì)胞
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Facilitating microglia M2 polarization alleviates p-Synephrine-induced depressive-like behaviours in CSDS mice via the 5-HT6R-FYN-ERK1/2 pathway (2024-12-31)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.113926
影響因子 ：4.8
引用產(chǎn)品： HMC3 細(xì)胞 , HMC3細(xì)胞專用培養(yǎng)基
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Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19 cognitive dysfunction through systems genetics approach (2024-08-12)
期刊：EXPERIMENTAL NEUROLOGY
DOI：10.1016/j.expneurol.2024.114921
影響因子 ：4.6
引用產(chǎn)品： MO3.13 細(xì)胞 , HMC3 細(xì)胞
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Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI (2024-10-30)
期刊：INFLAMMATION
DOI：10.1007/s10753-024-02171-7
影響因子 ：4.5
引用產(chǎn)品： HMC3 細(xì)胞
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N-Salicyloyl Tryptamine Derivatives as Potent Neuroinflammation Inhibitors by Constraining Microglia Activation via a STAT3 Pathway (2024-06-12)
期刊：ACS Chemical Neuroscience
DOI：10.1021/acschemneuro.4c00060
影響因子 ：4.1
引用產(chǎn)品： SH-SY5Y [SHSY-5Y] 細(xì)胞 , BV2 細(xì)胞 , HMC3 細(xì)胞
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EP300 regulates the SLC16A1-AS1-AS1/TCF3 axis to promote lung cancer malignancies through the Wnt signaling pathway (2024-03-07)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e27727
影響因子 ：3.4
引用產(chǎn)品： HS 683 細(xì)胞 , T98G 細(xì)胞 , HMC3 細(xì)胞
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Oxidized low-density lipoprotein changes the inflammatory status and metabolomics profiles in human and mouse macrophages and microglia (2024-03-29)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e28806
影響因子 ：3.4
引用產(chǎn)品： BV2 細(xì)胞 , J774A.1 細(xì)胞 , HMC3 細(xì)胞 , THP-1 細(xì)胞
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Estimates of Natural Frequencies for Nuclear Vibration, and an Assessment of the Feasibility of Selective Ultrasound Ablation of Cancer Cells (2024-10-11)
期刊：Journal of the Mechanical Behavior of Biomedical Materials
DOI：10.1016/j.jmbbm.2024.106778
影響因子 ：3.3
引用產(chǎn)品： HMC3 細(xì)胞 , Ham's F-10 培養(yǎng)基 , MEM 培養(yǎng)基 , 人神經(jīng)星形膠質(zhì)細(xì)胞 , GH3 細(xì)胞 , 磷酸鹽緩沖液（PBS） 1× , Ham's F-12K 培養(yǎng)基 , NSC-34 細(xì)胞 , U-87 MG 細(xì)胞 , MMQ 細(xì)胞 , BV2 (DMEM) 細(xì)胞 , GL261 細(xì)胞 , DMEM高糖 培養(yǎng)基
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Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments (2024-09-15)
期刊：NEUROMOLECULAR MEDICINE
DOI：10.1007/s12017-024-08804-2
影響因子 ：3.3
引用產(chǎn)品： MEM（ATCC改良） 培養(yǎng)基 , HMC3 細(xì)胞
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Severe hypoglycaemia-induced microglial inflammation damages microvascular endothelial cells, leading to retinal destruction (2024-08-26)
期刊：Diabetes & Vascular Disease Research
影響因子 ：2.8
引用產(chǎn)品： HMC3 細(xì)胞
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Jagged1-Notch1 Signaling Pathway Induces M1 Microglia to Disrupt the Barrier Function of Retinal Microvascular Endothelial Cells (2024-05-23)
期刊：CURRENT EYE RESEARCH
DOI：10.1080/02713683.2024.2357601
影響因子 ：2.0
引用產(chǎn)品： HMC3 細(xì)胞 , DMEM低糖 培養(yǎng)基 , HMC3細(xì)胞專用培養(yǎng)基
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Regulation of a novel circATP8B4/miR-31-5p/nestin ceRNA crosstalk in proliferation, motility, invasion and radiosensitivity of human glioma cells (2024-09-17)
期刊：JOURNAL OF RADIATION RESEARCH
影響因子 ：1.9
引用產(chǎn)品： T98G 細(xì)胞 , HMC3 細(xì)胞 , U251 細(xì)胞 , A172 細(xì)胞 , LN229 [LN-229; LNT-229] 細(xì)胞
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CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord (2023-10-31)
期刊：NATURE
DOI：10.1038/s41586-023-06783-1
影響因子 ：64.8
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Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system (2023-06-22)
期刊：Nature Biomedical Engineering
DOI：10.1038/s41551-023-01054-w
影響因子 ：28.1
引用產(chǎn)品： HULEC-5a 細(xì)胞 , HULEC-5a細(xì)胞專用培養(yǎng)基 , HMC3 細(xì)胞 , MEM (含NEAA) 培養(yǎng)基
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Nanoplastic Stimulates the Amyloidogenesis of Parkinson's Alpha-Synuclein NACore (2023-11-21)
期刊：Small
影響因子 ：13.3
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Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination (2023-03-25)
期刊：Journal of Neuroinflammation
DOI：10.1186/s12974-023-02764-3
影響因子 ：9.3
引用產(chǎn)品： HMC3 細(xì)胞 , MEM完全培養(yǎng)基 (含10%FBS）
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α-Synuclein Induces Neuroinflammation Injury through the IL6ST-AS/STAT3/HIF-1α Axis (2023-01-11)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.6
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Parthenolide alleviates microglia‐mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder (2023-05-12)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110287
影響因子 ：5.6
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BAFF deficiency aggravated optic nerve crush-induced retinal ganglion cells damage by regulating apoptosis and neuroinflammation via NF-κB-IκBα signaling (2023-12-04)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111287
影響因子 ：5.6
引用產(chǎn)品： HMC3 細(xì)胞
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Oncolytic Viral Therapy for Glioma by Recombinant Sindbis Virus (2023-09-27)
期刊：Cancers
影響因子 ：5.2
引用產(chǎn)品： U-87 MG 細(xì)胞 , BV2 細(xì)胞 , HMC3 細(xì)胞 , U-118 MG 細(xì)胞 , C6 細(xì)胞 , GL261 細(xì)胞
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Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling (2023-09-25)
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-023-03656-6
影響因子 ：5.1
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LASSO-based screening for potential prognostic biomarkers associated with glioblastoma (2023-01-16)
期刊：Frontiers in Oncology
影響因子 ：4.7
引用產(chǎn)品： HMC3 細(xì)胞 , U251 細(xì)胞
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Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization (2023-02-06)
期刊：Pharmaceuticals
影響因子 ：4.6
引用產(chǎn)品： HMC3 細(xì)胞 , U251 細(xì)胞
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Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson’s Disease (2023-07-28)
期刊：ACS Omega
影響因子 ：4.1
引用產(chǎn)品： SH-SY5Y [SHSY-5Y] 細(xì)胞 , HMC3 細(xì)胞
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Elevated LILRB1 expression predicts poor prognosis and is associated with tumor immune infiltration in patients with glioma (2023-05-04)
期刊：BMC CANCER
DOI：10.1186/s12885-023-10906-2
影響因子 ：3.8
引用產(chǎn)品： HMC3 細(xì)胞
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Triptolide improves Alzheimer's disease by regulating the NF?κB signaling pathway through the lncRNA NEAT1/microRNA 361?3p/TRAF2 axis (2023-08-01)
期刊：Experimental and Therapeutic Medicine
影響因子 ：2.7
引用產(chǎn)品： HMC3 細(xì)胞
-
Microglia increase CEMIP expression and promote brain metastasis in breast cancer through the JAK2/STAT3 signaling pathway (2023-11-21)
期刊：Oncologie
DOI：10.1515/oncologie-2023-0312
影響因子 ：0.9
引用產(chǎn)品： HMC3 細(xì)胞
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Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line (2022-09-23)
期刊：ENVIRONMENTAL POLLUTION
DOI：10.1016/j.envpol.2022.120217
影響因子 ：10.0
引用產(chǎn)品： HMC3 細(xì)胞 , HMC3細(xì)胞專用培養(yǎng)基
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lncRNA SND1-IT1 delivered via intracerebral hemorrhage-derived exosomes affect the growth of human microglia by regulating the miR-124-3p/MTF1 axis (2022-12-22)
期刊：JOURNAL OF CELLULAR PHYSIOLOGY
影響因子 ：6.5
引用產(chǎn)品： HMC3 細(xì)胞
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TMEM16F may be a new therapeutic target for Alzheimer’s disease (2022-08-02)
期刊：Neural Regeneration Research
影響因子 ：6.1
引用產(chǎn)品： HMC3 細(xì)胞 , MEM (含NEAA) 培養(yǎng)基 , 特級胎牛血清 , DMEM低糖 (不含酚紅) 培養(yǎng)基
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Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF (2022-11-30)
期刊：Aging-US
影響因子 ：6.0
引用產(chǎn)品： HMC3 細(xì)胞
-
Malignant Melanoma-Derived Exosomes Induce Endothelial Damage and Glial Activation on a Human BBB Chip Model (2022-01-31)
期刊：Biosensors-Basel
影響因子 ：5.7
引用產(chǎn)品： MEM（含NEAA） 培養(yǎng)基 , HMC3 細(xì)胞
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Iron oxide nanoparticles loaded with paclitaxel inhibits glioblastoma by enhancing autophagy-dependent ferroptosis pathway (2022-03-09)
期刊：European Journal Of Pharmacology
DOI：10.1016/j.ejphar.2022.174860
影響因子 ：5.0
引用產(chǎn)品： HMC3 細(xì)胞
-
LINC01088 promotes the growth and invasion of glioma cells through regulating small nuclear ribonucleoprotein polypeptide A transcription (2022-04-07)
期刊：Bioengineered.
DOI：10.1080/21655979.2022.2051786
影響因子 ：4.9
引用產(chǎn)品： HMC3 細(xì)胞 , U251 細(xì)胞 , T98G 細(xì)胞
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C1R, CCL2, and TNFRSF1A Genes in Coronavirus Disease-COVID-19 Pathway Serve as Novel Molecular Biomarkers of GBM Prognosis and Immune Infiltration (2022-06-18)
期刊：DISEASE MARKERS
影響因子 ：3.5
引用產(chǎn)品： HMC3 細(xì)胞
-
lncRNA MSC-AS1 Aggravates Diabetic Nephropathy by Regulating the miR-325/CCNG1 Axis (2022-01-25)
期刊：Journal of Healthcare Engineering
影響因子 ：0.0
引用產(chǎn)品： 人腎小球系膜細(xì)胞完全培養(yǎng)基 , HMC3 細(xì)胞
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Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B (2021-12-04)
期刊：Diabetology & Metabolic Syndrome
DOI：10.1186/s13098-021-00757-x
影響因子 ：4.8
引用產(chǎn)品： HMC細(xì)胞專用培養(yǎng)基 , HMC3 細(xì)胞
-
Amorfrutins Relieve Neuropathic Pain through the PPARγ/CCL2 Axis in CCI Rats (2021-01-22)
期刊：PPAR Research
影響因子 ：2.9
引用產(chǎn)品： HMC3 細(xì)胞
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