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產(chǎn)品概述
| 名稱 | ARPE-19 (人視網(wǎng)膜上皮細(xì)胞) (STR鑒定正確) |
| 別稱 | ARPE19; Adult Retinal Pigment Epithelial cell line-19; NTC-200; NTC200 |
| 種屬 | 人 |
| 生長(zhǎng)特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:5 |
| 推薦換液頻率 | 2-3次/周 |
| 年齡（性別） | 男性；19歲 |
| 組織來(lái)源 | 眼睛，視網(wǎng)膜 |
| 細(xì)胞類型 | 自發(fā)永生化細(xì)胞 |
| 生物安全等級(jí) | BSL-1 |
| 倍增時(shí)間 | ~55-65 hours |
| 基因表達(dá)情況 | RPE-specific markers CRALBP and RPE-65 |
| 保藏機(jī)構(gòu) | ATCC; CRL-2302 BCRC; 60383 BCRJ; 0041 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X,Y CSF1PO 11 D2S1338 19 D3S1358 14,15 D5S818 13 D7S820 9,11 D8S1179 13 D13S317 11,12 D16S539 9,11 D18S51 12,16 D19S433 12,13 D21S11 28,29 FGA 23 PentaD 11,13 PentaE 7,11 TH01 6,9.3 TPOX 9,11 vWA 16,19 D6S1043 17,19 D12S391 21,22 D2S441 10,15 -
STR鑒定圖
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參考文獻(xiàn)
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Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis through the Keap1/Nrf2/HO-1 signaling pathway (2025-02-07)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-024-03082-3
影響因子 ：10.6
引用產(chǎn)品： ARPE-19 細(xì)胞
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Naringin Suppresses CoCl2-Induced Ferroptosis in ARPE-19 Cells (2025-02-18)
期刊：Antioxidants
影響因子 ：6.0
引用產(chǎn)品： ARPE-19 細(xì)胞
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Hirudo extract ameliorates proliferative vitreoretinopathy by promoting autophagy and attenuating the THBS2/PI3K/Akt pathway (2025-01-08)
期刊：Scientific Reports
DOI：10.1038/s41598-025-85882-7
影響因子 ：3.8
引用產(chǎn)品： ARPE-19 細(xì)胞
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Lycium barbarum polysaccharide alleviates H2O2-induced premature senescence by downregulating miRNA-34a-5p in ARPE-19 cells (2025-03-18)
期刊：CELL STRESS & CHAPERONES
DOI：10.1016/j.cstres.2025.03.002
影響因子 ：3.3
引用產(chǎn)品： ARPE-19 細(xì)胞
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Asperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis (2025-01-07)
期刊：Frontiers in Medicine
影響因子 ：3.1
引用產(chǎn)品： ARPE-19 細(xì)胞
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YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy (2025-02-24)
期刊：Journal of Diabetes Investigation
影響因子 ：3.1
引用產(chǎn)品： ARPE-19 細(xì)胞 , ARPE-19細(xì)胞專用培養(yǎng)基
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USP14-Dependent IGF1R Aggravates High Glucose-Induced Diabetic Retinopathy by Upregulating BAP1 (2025-03-31)
期刊：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
DOI：10.1007/s12010-025-05215-2
影響因子 ：3.1
引用產(chǎn)品： ARPE-19 細(xì)胞
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Senescent retinal pigment epithelial cells promote angiogenesis in choroidal neovascularization via the TAK1/p38 MAPK pathway (2025-01-06)
期刊：EXPERIMENTAL EYE RESEARCH
DOI：10.1016/j.exer.2025.110232
影響因子 ：3.0
引用產(chǎn)品： ARPE-19 細(xì)胞
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SRSF10 regulates isoform expression of transcripts associated with proliferative diabetes retinopathy in ARPE-19 cells based on long-read RNA and immunoprecipitation sequencing (2025-03-14)
期刊：GENE
DOI：10.1016/j.gene.2025.149412
影響因子 ：2.6
引用產(chǎn)品： ARPE-19 細(xì)胞 , DMEM/F12 培養(yǎng)基
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BlingLife?-Marigold Extract Alleviates Blue Light-Induced Retinal Mitochondria Oxidative Stress and Senescence by Activating NRF2/HO-1 Signaling (2025-02-24)
期刊：JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
影響因子 ：2.5
引用產(chǎn)品： ARPE-19 細(xì)胞
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Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization (2024-11-13)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-024-02943-1
影響因子 ：10.6
引用產(chǎn)品： ARPE-19 細(xì)胞 , 特級(jí)胎牛血清 , 人臍靜脈內(nèi)皮細(xì)胞 , 青霉素-鏈霉素溶液（雙抗），100× , 293T [HEK-293T] 細(xì)胞 , DMEM高糖 培養(yǎng)基 , 人臍靜脈內(nèi)皮細(xì)胞完全培養(yǎng)基
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Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis (2024-06-28)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2024.06.047
影響因子 ：10.5
引用產(chǎn)品： ARPE-19 細(xì)胞 , HMC3細(xì)胞專用培養(yǎng)基 , HMC3 細(xì)胞
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Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies (2024-07-11)
期刊：Cell Communication and Signaling
DOI：10.1186/s12964-024-01710-x
影響因子 ：8.2
引用產(chǎn)品： ARPE-19 細(xì)胞
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AI-driven determination of active compounds and investigation of multi-pharmacological effects of Chrysanthemi Flos (2024-08-13)
期刊：COMPUTERS IN BIOLOGY AND MEDICINE
DOI：10.1016/j.compbiomed.2024.108985
影響因子 ：7.0
引用產(chǎn)品： RAW 264.7 細(xì)胞 , ARPE-19 細(xì)胞 , Hep G2 細(xì)胞
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Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration (2024-03-25)
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2024.102176
影響因子 ：6.5
引用產(chǎn)品： 293T [HEK-293T] 細(xì)胞 , ARPE-19 細(xì)胞
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Overexpressed Poldip2 incurs retinal fibrosis via the TGFβ1/SMAD3 signaling pathway in diabetic retinopathy (2024-07-05)
期刊：DIABETES
影響因子 ：6.2
引用產(chǎn)品： DMEM/F12 培養(yǎng)基 , ARPE-19 細(xì)胞
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Triptonide protects retinal cells from oxidative damage via activation of Nrf2 signaling (2024-07-08)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
影響因子 ：5.7
引用產(chǎn)品： ARPE-19 細(xì)胞
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Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells (2024-10-01)
期刊：INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影響因子 ：5.0
引用產(chǎn)品： DMEM高糖 培養(yǎng)基 , 小鼠視網(wǎng)膜Muller細(xì)胞 , DMEM/F12 培養(yǎng)基 , ARPE-19 細(xì)胞 , BV2 (DMEM) 細(xì)胞
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Flexible nano-liposomes-encapsulated recombinant UL8-siRNA (r/si-UL8) based on bioengineering strategy inhibits herpes simplex virus-1 infection (2024-06-21)
期刊：ANTIVIRAL RESEARCH
DOI：10.1016/j.antiviral.2024.105936
影響因子 ：4.5
引用產(chǎn)品： ARPE-19 細(xì)胞 , Hacat 細(xì)胞 , VERO C1008 [Vero E6] 細(xì)胞
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The circular RNA circSLC16A10 alleviates diabetic retinopathy by improving mitochondrial function via the miR-761-5p/MFN2 axis (2024-07-02)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2024.111283
影響因子 ：4.4
引用產(chǎn)品： ARPE-19 細(xì)胞 , D-葡萄糖溶液（200 g/L） , 293T [HEK-293T] 細(xì)胞
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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells (2024-05-14)
期刊：Human Cell
DOI：10.1007/s13577-024-01075-w
影響因子 ：4.3
引用產(chǎn)品： ARPE-19 細(xì)胞
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Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina (2024-03-15)
期刊：World Journal of Diabetes
影響因子 ：4.2
引用產(chǎn)品： ARPE-19 細(xì)胞 , DMEM高糖 培養(yǎng)基
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YTHDF1-regulated ALOX5 in retinal pigment epithelial cells under hypoxia enhances VEGF expression and promotes viability, migration, and angiogenesis of vascular endothelial cells (2024-10-05)
期刊：Scientific Reports
DOI：10.1038/s41598-024-72388-x
影響因子 ：3.8
引用產(chǎn)品： ARPE-19 細(xì)胞 , DMEM/F12 培養(yǎng)基
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Tropisetron attenuates high glucose-induced oxidative stress and inflammation in ARPE-19 cells in vitro via regulating SIRT1/ROCK1 signaling (2024-10-09)
期刊：DRUG DEVELOPMENT RESEARCH
影響因子 ：3.5
引用產(chǎn)品： ARPE-19 細(xì)胞
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Role of HDAC3 in the epithelial-mesenchymal transition of retinal pigment epithelium cells: implications for proliferative vitreoretinopathy (2024-10-11)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e39333
影響因子 ：3.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis (2024-04-16)
期刊：MICROVASCULAR RESEARCH
影響因子 ：3.1
引用產(chǎn)品： ARPE-19 細(xì)胞
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Identification of biomarkers associated with ferroptosis in diabetic retinopathy based on WGCNA and machine learning (2024-05-28)
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2024.1376771
影響因子 ：2.8
引用產(chǎn)品： ARPE-19 細(xì)胞
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PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress (2024-10-15)
期刊：Diagnostic Pathology
DOI：10.1186/s13000-024-01556-4
影響因子 ：2.4
引用產(chǎn)品： ARPE-19細(xì)胞專用培養(yǎng)基 , 293T [HEK-293T] 細(xì)胞 , ARPE-19 細(xì)胞
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Silencing the long noncoding RNA MALAT1 inhibits vitreous-induced epithelial–mesenchymal transition in RPE cells by regulating the PDGFRs/AKT axis (2024-09-04)
期刊：INTERNATIONAL OPHTHALMOLOGY
DOI：10.1007/s10792-024-03295-3
影響因子 ：1.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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Extracellular vesicles from organoid-derived human retinal progenitor cells prevent lipid overload-induced retinal pigment epithelium injury by regulating fatty acid metabolism (2023-12-27)
期刊：Journal of Extracellular Vesicles
影響因子 ：16.0
引用產(chǎn)品： ARPE-19 細(xì)胞
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Cooperative phototherapy based on bimodal imaging guidance for the treatment of uveal melanoma (2023-05-04)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-01891-6
影響因子 ：10.2
引用產(chǎn)品： C918 細(xì)胞 , ARPE-19 細(xì)胞
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PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation (2023-01-23)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05590-w
影響因子 ：9.0
引用產(chǎn)品： ARPE-19 細(xì)胞
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A novel recombinant ORF7-siRNA delivered by flexible nano-liposomes inhibits varicella zoster virus infection (2023-09-12)
期刊：Cell and Bioscience
DOI：10.1186/s13578-023-01108-1
影響因子 ：7.5
引用產(chǎn)品： ARPE-19 細(xì)胞 , Hacat 細(xì)胞
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Development of Uveal Melanoma-Specific Aptamer for Potential Biomarker Discovery and Targeted Drug Delivery (2023-02-22)
期刊：ANALYTICAL CHEMISTRY
DOI：10.1021/acs.analchem.3c00005
影響因子 ：7.4
引用產(chǎn)品： C918 細(xì)胞 , ARPE-19 細(xì)胞
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Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk sequencing data (2023-01-30)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1099071
影響因子 ：7.3
引用產(chǎn)品： ARPE-19 細(xì)胞 , C918 細(xì)胞
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Efficiency co-delivery of ellagic acid and oxygen by a non-invasive liposome for ameliorating diabetic retinopathy (2023-05-18)
期刊：INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI：10.1016/j.ijpharm.2023.122987
影響因子 ：5.8
引用產(chǎn)品： ARPE-19 細(xì)胞 , 人臍靜脈內(nèi)皮細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and Inhibits Choroidal Neovascularization (2023-10-24)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.6
引用產(chǎn)品： ARPE-19 細(xì)胞 , THP-1 細(xì)胞
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Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Choroid (2023-09-01)
期刊：INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影響因子 ：4.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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Integrated network pharmacology and experimental validation to explore the potential pharmacological mechanism of Qihuang Granule and its main ingredients in regulating ferroptosis in AMD (2023-11-21)
期刊：BMC Complementary Medicine and Therapies
DOI：10.1186/s12906-023-04205-3
影響因子 ：3.9
引用產(chǎn)品： ARPE-19 細(xì)胞
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Exome sequencing reveals PPEF2 variant associated with high myopia (2023-12-16)
期刊：GENE
DOI：10.1016/j.gene.2023.148091
影響因子 ：3.5
引用產(chǎn)品： 293T [HEK-293T] 細(xì)胞 , ARPE-19 細(xì)胞
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Acteoside inhibits high glucose-induced oxidative stress injury in RPE cells and the outer retina through the Keap1/Nrf2/ARE pathway (2023-05-31)
期刊：EXPERIMENTAL EYE RESEARCH
DOI：10.1016/j.exer.2023.109496
影響因子 ：3.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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Fetuin-B Overexpression Promotes Inflammation in Diabetic Retinopathy Through Activating Microglia and the NF-κB Signaling Pathway (2023-10-26)
期刊：CURRENT EYE RESEARCH
DOI：10.1080/02713683.2023.2276683
影響因子 ：2.0
引用產(chǎn)品： ARPE-19 細(xì)胞 , BV2 細(xì)胞 , DMEM高糖 培養(yǎng)基
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All-trans retinoic acid regulates the expression of MMP-2 and TGF-β2 via RDH5 in retinal pigment epithelium cells (2023-06-18)
期刊：International Journal of Ophthalmology
影響因子 ：1.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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Inhibition of chaetocin on retinoblastoma progression by modulating the miR-124/SBK1 axis (2023-12-01)
期刊：Materials Express
影響因子 ：0.7
引用產(chǎn)品： WERI-Rb-1 細(xì)胞 , ARPE-19 細(xì)胞
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Fundus-Vascular Responses to Color Deviation Caused by Non-Oxidative Blue Filtering (2022-10-12)
期刊：Oxidative Medicine and Cellular Longevity
影響因子 ：7.3
引用產(chǎn)品： ARPE-19 細(xì)胞
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Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2 (2022-03-18)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2049471
影響因子 ：4.9
引用產(chǎn)品： ARPE-19 細(xì)胞
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Long non?coding RNA MALAT1 is involved in retinal pigment epithelial cell damage caused by high glucose treatment (2022-03-21)
期刊：Molecular Medicine Reports
影響因子 ：3.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells (2022-03-29)
期刊：Oxidative Medicine and Cellular Longevity
影響因子 ：0.0
引用產(chǎn)品： WERI-Rb-1 細(xì)胞 , ARPE-19 細(xì)胞
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MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells (2021-07-15)
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03956-6
影響因子 ：9.0
引用產(chǎn)品： ARPE-19 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization (2021-05-06)
期刊：Life Sciences
影響因子 ：6.8
引用產(chǎn)品： BV2 細(xì)胞 , ARPE-19 細(xì)胞 , DMEM/F12 培養(yǎng)基
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Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway (2021-11-25)
期刊：Current Eye Research
DOI：10.1080/02713683.2021.1925697
影響因子 ：2.0
引用產(chǎn)品： ARPE-19 細(xì)胞
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Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells (2021-06-18)
期刊：International Journal of Ophthalmology
影響因子 ：1.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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Gambogic acid ameliorates high glucose– and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo (2020-11-27)
期刊：Cell Stress & Chaperones
DOI：10.1007/s12192-020-01182-1
影響因子 ：3.8
引用產(chǎn)品： DMEM/F12 培養(yǎng)基 , ARPE-19 細(xì)胞
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Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells (2019-04-18)
期刊：International Journal of Ophthalmology
影響因子 ：1.4
引用產(chǎn)品： ARPE-19 細(xì)胞
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Aligned Nanofibers from Polypyrrole/Graphene as Electrodes for Regeneration of Optic Nerve via Electrical Stimulation (2016-03-09)
期刊：ACS Applied Materials & Interfaces
影響因子 ：9.5
引用產(chǎn)品： ARPE-19 細(xì)胞
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