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產(chǎn)品概述
| 名稱 | GC-2spd(ts) (小鼠精母細胞) (STR鑒定正確) |
| 別稱 | GC-2 |
| 種屬 | 小鼠 |
| 生長特性 | 貼壁細胞 |
| 細胞形態(tài) | 上皮細胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:3-1:6 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | The cells have lost their differentiation potential, and are currently arrested at a premeiotic stage. |
| 年齡（性別） | 雄性；6周齡 |
| 組織來源 | 精母細胞；SV40大T抗原轉(zhuǎn)染 |
| 細胞類型 | 條件永生化細胞系 |
| 生物安全等級 | BSL-2 |
| 應(yīng)用領(lǐng)域 | This cell line may be useful for the study of spermatogenesis. |
| 保藏機構(gòu) | ATCC; CRL-2196 BCRC; 60313 |
STR鑒定
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STR位點信息
18-3 16,17 6-7 17 5-5 14,17,18,19 X-1 28 1-2 13,19 7-1 26.2,29 8-1 16 1-1 17 19-2 13 15-3 22.3 12-1 17 6-4 18 4-2 20.3 3-2 14 2-1 16 13-1 15.2,17.1
11-2 16 17-2 15 -
STR鑒定圖
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參考文獻
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Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice (2025-01-27)
期刊：ACS Nano
影響因子 ：15.8
引用產(chǎn)品： TM4 細胞 , GC-2spd(ts) 細胞
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Gut-Derived Exosomes Mediate the Microbiota Dysbiosis-Induced Spermatogenesis Impairment by Targeting Meioc in Mice (2024-03-25)
期刊：Advanced Science
影響因子 ：15.1
引用產(chǎn)品： GC-1 spg 細胞 , GC-2spd (ts) 細胞
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The necroptosis-mediated imbalance of mitochondrial dynamics is involved in DEHP-induced toxicity to immature testes via the PGAM5–DRP1 interaction (2024-02-15)
期刊：ENVIRONMENTAL POLLUTION
DOI：10.1016/j.envpol.2024.123585
影響因子 ：8.9
引用產(chǎn)品： GC-1 spg 細胞 , GC-2spd (ts) 細胞
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Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction (2024-02-17)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.02.006
影響因子 ：7.4
引用產(chǎn)品： GC-2spd (ts) 細胞
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Triptolide induced spermatogenesis dysfunction via ferroptosis activation by promoting K63-linked GPX4 polyubiquitination in spermatocytes (2024-07-02)
期刊：CHEMICO-BIOLOGICAL INTERACTIONS
影響因子 ：4.7
引用產(chǎn)品： GC-2spd(ts) 細胞
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Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis (2024-01-05)
期刊：Scientific Reports
DOI：10.1038/s41598-024-51224-2
影響因子 ：4.6
引用產(chǎn)品： GC-2spd (ts) 細胞
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Triptolide Causes Spermatogenic Disorders by Inducing Apoptosis in the Mitochondrial Pathway of Mouse Testicular Spermatocytes (2024-12-10)
期刊：Toxics
影響因子 ：3.9
引用產(chǎn)品： GC-2spd(ts) 細胞
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Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury: Impact on the regulation of germ cell proliferation and apoptosis (2024-10-17)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.114285
影響因子 ：3.3
引用產(chǎn)品： GC-2spd(ts) 細胞
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Multi-omics revealed activation of TNF-α induced apoptosis signaling pathway in testis of DEHP treated prepubertal male rat (2024-11-28)
期刊：REPRODUCTIVE TOXICOLOGY
DOI：10.1016/j.reprotox.2024.108758
影響因子 ：3.3
引用產(chǎn)品： GC-2spd(ts) 細胞
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Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis (2024-10-22)
期刊：Andrology
影響因子 ：3.2
引用產(chǎn)品： 特級胎牛血清 , GC-1 spg 細胞 , TM3 細胞 , TM4 細胞 , GC-2spd(ts) 細胞
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Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes (2024-11-13)
期刊：MOLECULAR BIOLOGY REPORTS
DOI：10.1007/s11033-024-10096-5
影響因子 ：2.6
引用產(chǎn)品： 293T [HEK-293T] 細胞 , GC-2spd(ts) 細胞
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Oxidative and Endoplasmic Reticulum Stress Mediate Testicular Injury in a Rat Model of Varicocele (2024-12-05)
期刊：Reproductive Sciences
DOI：10.1007/s43032-024-01749-8
影響因子 ：2.6
引用產(chǎn)品： GC-2spd(ts) 細胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清 , 青霉素-鏈霉素溶液（雙抗），100×
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The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis (2023-09-27)
期刊：Microbiome
DOI：10.1186/s40168-023-01659-y
影響因子 ：15.5
引用產(chǎn)品： GC-2spd (ts) 細胞
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X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity (2023-03-27)
期刊：Genes & Diseases
DOI：10.1016/j.gendis.2023.02.030
影響因子 ：6.8
引用產(chǎn)品： GC-1 spg 細胞 , GC-2spd (ts) 細胞
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The rare-earth yttrium induces cell apoptosis and autophagy in the male reproductive system through ROS-Ca2+-CamkII/Ampk axis (2023-07-20)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115262
影響因子 ：6.8
引用產(chǎn)品： TM4 細胞 , TM3 細胞 , GC-1 spg 細胞 , GC-2spd (ts) 細胞 , DMEM/F12 培養(yǎng)基 , DMEM高糖 培養(yǎng)基
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N-acetylcysteine rescues meiotic arrest during spermatogenesis in mice exposed to BDE-209 (2023-02-18)
期刊：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
DOI：10.1007/s11356-023-25874-0
影響因子 ：5.8
引用產(chǎn)品： GC-2spd (ts) 細胞
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Loss of histone reader Phf7 leads to immune pathways activation via endogenous retroviruses during spermiogenesis (2023-09-25)
期刊：iScience
DOI：10.1016/j.isci.2023.108030
影響因子 ：5.8
引用產(chǎn)品： GC-1 spg 細胞 , GC-2spd(ts) 細胞
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Bisphenol A exposure decreases sperm production and male fertility through inhibition PCBP2 expression (2023-11-20)
期刊：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
DOI：10.1007/s11356-023-30815-y
影響因子 ：5.8
引用產(chǎn)品： GC-2spd(ts) 細胞
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Curcumin attenuates diphenyl phosphate-induced apoptosis in GC-2spd(ts) cells through activated autophagy via the Nrf2/P53 pathway (2023-12-14)
期刊：ENVIRONMENTAL TOXICOLOGY
影響因子 ：4.5
引用產(chǎn)品： Annexin V-FITC/ PI熒光雙染細胞凋亡檢測試劑盒 , GC-2spd (ts) 細胞
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The crosstalk between M1 macrophage polarization and energy metabolism disorder contributes to polystyrene nanoplastics-triggered testicular inflammation (2023-08-26)
期刊：FOOD AND CHEMICAL TOXICOLOGY
影響因子 ：4.3
引用產(chǎn)品： RAW 264.7 細胞 , GC-2spd (ts) 細胞 , Annexin V-FITC/ PI熒光雙染細胞凋亡檢測試劑盒
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Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway (2023-06-05)
期刊：TOXICOLOGY IN VITRO
影響因子 ：3.2
引用產(chǎn)品： GC-1 spg 細胞 , GC-2spd (ts) 細胞
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BDE-209 induce spermatocytes arrest at early-pachytene stage during meiotic prophase I in mice (2021-12-20)
期刊：Toxicology
影響因子 ：4.5
引用產(chǎn)品： GC-2spd (ts) 細胞
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識別碼示意圖
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