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SK-N-SH (人神經(jīng)母細(xì)胞瘤細(xì)胞) (STR鑒定正確)
貨號：CL-0214
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價格： ￥1800
生長培養(yǎng)基：MEM（含NEAA）＋10% FBS＋1% P/S
產(chǎn)品概述
| 名稱 | SK-N-SH (人神經(jīng)母細(xì)胞瘤細(xì)胞) (STR鑒定正確) |
| 別稱 | SK N SH; SKN-SH; SK-NSH; SKNSH; NSH |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:4 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | SK-N-SH細(xì)胞是由J·L·Bieder建系，它與SK-N-MC細(xì)胞所不同的是倍增時間較長，且多巴胺-β-羥基酶水平較高。SK-N-SH細(xì)胞在細(xì)胞介導(dǎo)的細(xì)胞毒性試驗中用作靶細(xì)胞系。 |
| 年齡（性別） | 女性；4歲 |
| 組織來源 | 腦神經(jīng)母細(xì)胞瘤，轉(zhuǎn)移部位骨髓 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 神經(jīng)母細(xì)胞瘤細(xì)胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~44 hours |
| 抗原表達情況 | Blood Type A; Rh+ |
| 基因表達情況 | plasminogen activator, shows increased expression of M-CSF after treatment with amyloid-beta peptide. |
| 保藏機構(gòu) | ATCC; HTB-11 ECACC; 86012802 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 11 D2S1338 17,19 D3S1358 15,16 D5S818 12 D7S820 7,10 D8S1179 15 D13S317 11 D16S539 8,13 D18S51 13,16 D19S433 13,14 D21S11 31,31.2 FGA 23.2,24 PentaD 10,12 PentaE 7,11 TH01 7,10 TPOX 8,11 vWA 14,18 D6S1043 12,18 D12S391 18,22 D2S441 11,11.3 -
STR鑒定圖
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參考文獻
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Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis (2025-01-03)
期刊：Genes & Diseases
DOI：10.1016/j.gendis.2024.101511
影響因子 ：6.9
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SH-SY5Y [SHSY-5Y] 細(xì)胞
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Corydaline Alleviates 1-Methyl-4-Phenylpyridium (MPP+)-Induced Human Neuroblastoma Cell Injury by BAP1-NRF2/HO-1/GPX4 Pathway (2025-02-27)
期刊：NEUROCHEMICAL RESEARCH
DOI：10.1007/s11064-025-04351-9
影響因子 ：3.7
引用產(chǎn)品： SK-N-SH 細(xì)胞 , MEM（含NEAA） 培養(yǎng)基 , 特級胎牛血清 , 青霉素-鏈霉素溶液（雙抗），100×
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Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin (2024-05-14)
期刊：SCIENCE OF THE TOTAL ENVIRONMENT
DOI：10.1016/j.scitotenv.2024.173119
影響因子 ：9.8
引用產(chǎn)品： SK-N-SH 細(xì)胞
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Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases (2024-11-14)
期刊：Journal of Pharmaceutical Analysis
DOI：10.1016/j.jpha.2024.101149
影響因子 ：6.1
引用產(chǎn)品： SK-N-SH 細(xì)胞
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Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia‐reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis (2024-08-04)
期刊：CNS Neuroscience & Therapeutics
影響因子 ：4.8
引用產(chǎn)品： SK-N-SH 細(xì)胞
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CARM1-induced lncRNA NEAT1 synchronously activates MYCN and GalNAcT-I to accelerate the progression of neuroblastoma (2024-12-14)
期刊：GENE
DOI：10.1016/j.gene.2024.149164
影響因子 ：2.6
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SK-N-BE(2) 細(xì)胞 , IMR-32 細(xì)胞 , 293T [HEK-293T] 細(xì)胞 , Ham's F-12 培養(yǎng)基 , 青霉素-鏈霉素溶液（雙抗），100×
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Schisandrin A Alleviates Inflammation and Oxidative Stress in Aβ25-35-Induced Alzheimer’s Disease in Vitro Model (2024-10-05)
期刊：ACTAS ESPANOLAS DE PSIQUIATRIA
影響因子 ：1.0
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SH-SY5Y [SHSY-5Y] 細(xì)胞
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Resveratrol alleviates amyloid β-induced neuronal apoptosis, inflammation, and oxidative and endoplasmic reticulum stress by circ_0050263/miR-361-3p/PDE4A axis during Alzheimer's disease (2023-08-24)
期刊：Chemical Biology & Drug Design
影響因子 ：3.0
引用產(chǎn)品： SK-N-SH 細(xì)胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清
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Icariside II protects dopaminergic neurons from 1?methyl?4?phenylpyridinium?induced neurotoxicity by downregulating HDAC2 to restore mitochondrial function (2023-11-28)
期刊：Experimental and Therapeutic Medicine
影響因子 ：2.7
引用產(chǎn)品： SK-N-SH 細(xì)胞
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Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis (2022-02-02)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2022.01.031
影響因子 ：7.4
引用產(chǎn)品： SK-N-SH 細(xì)胞 , 293T [HEK-293T] 細(xì)胞
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C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone (2022-08-09)
期刊：Communications Biology
DOI：10.1038/s42003-022-03768-0
影響因子 ：6.6
引用產(chǎn)品： SK-N-SH 細(xì)胞
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Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner (2022-09-29)
期刊：JOURNAL OF VIROLOGY
影響因子 ：6.5
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SK-N-SH細(xì)胞專用培養(yǎng)基
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bub1 as a potential oncogene and a prognostic biomarker for neuroblastoma (2022-09-27)
期刊：Frontiers in Oncology
影響因子 ：5.7
引用產(chǎn)品： SH-SY5Y [SHSY-5Y] 細(xì)胞 , SK-N-SH 細(xì)胞
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Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model (2022-01-10)
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2021.108464
影響因子 ：5.6
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SK-N-SH細(xì)胞專用培養(yǎng)基
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Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis (2022-02-25)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2042999
影響因子 ：4.9
引用產(chǎn)品： 人臍靜脈內(nèi)皮細(xì)胞 , SH-SY5Y [SHSY-5Y] 細(xì)胞 , SK-N-SH 細(xì)胞 , SK-N-AS 細(xì)胞 , SK-N-BE (2) 細(xì)胞
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CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma (2022-02-15)
期刊：Frontiers in Oncology
影響因子 ：4.7
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SH-SY5Y [SHSY-5Y] 細(xì)胞
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CircAXL Knockdown Alleviates Aβ1-42-Induced Neurotoxicity in Alzheimer’s Disease via Repressing PDE4A by Releasing miR-1306-5p (2022-03-01)
期刊：Neurochemical Research
DOI：10.1007/s11064-022-03563-7
影響因子 ：4.4
引用產(chǎn)品： SK-N-SH 細(xì)胞
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Long non-coding RNA UCA1 regulates MPP+-induced neuronal damage through the miR-671-5p/KPNA4 pathway in SK-N-SH cells (2022-12-14)
期刊：METABOLIC BRAIN DISEASE
DOI：10.1007/s11011-022-01118-x
影響因子 ：3.7
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SK-N-SH細(xì)胞專用培養(yǎng)基
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Circ_0001360 absence alleviates oxygen-glucose deprivation/reoxygenation-induced SK-N-SH cell injury via controlling the miR-671-5p/BMF pathway (2022-12-16)
期刊：INTERNATIONAL JOURNAL OF NEUROSCIENCE
DOI：10.1080/00207454.2022.2118598
影響因子 ：2.6
引用產(chǎn)品： SK-N-SH 細(xì)胞
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HMGB3 is Associated With an Unfavorable Prognosis of Neuroblastoma and Promotes Tumor Progression by Mediating TPX2 (2021-12-20)
期刊：Frontiers in Cell and Developmental Biology
影響因子 ：5.5
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SH-SY5Y [SHSY-5Y] 細(xì)胞 , SK-N-BE (2) 細(xì)胞
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LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis (2021-06-21)
期刊：Neuropsychiatric Disease and Treatment
影響因子 ：3.0
引用產(chǎn)品： IMR-32 細(xì)胞 , SK-N-SH 細(xì)胞 , 293 [HEK-293] 細(xì)胞 , DMEM高糖 培養(yǎng)基 , 特級胎牛血清 , DMEM高糖 培養(yǎng)基
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Long Noncoding RNA SNHG1 Knockdown Ameliorates Apoptosis, Oxidative Stress and Inflammation in Models of Parkinson’s Disease by Inhibiting the miR-125b-5p/MAPK1 Axis (2021-04-22)
期刊：Neuropsychiatric Disease and Treatment
影響因子 ：3.0
引用產(chǎn)品： SK-N-SH 細(xì)胞 , 小鼠多巴胺神經(jīng)元細(xì)胞 , MN9D 細(xì)胞
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miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2 (2021-01-01)
期刊：Open Life Sciences
影響因子 ：2.2
引用產(chǎn)品： SK-N-SH 細(xì)胞
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Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis (2020-10-08)
期刊：Iubmb Life
DOI：10.1002/iub.2392
影響因子 ：4.6
引用產(chǎn)品： SK-N-SH 細(xì)胞 , SK-N-AS 細(xì)胞
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LncRNA NEAT1 Regulates the Development of Parkinson’s Disease by Targeting AXIN1 Via Sponging miR-212-3p (2020-11-26)
期刊：Neurochemical Research
DOI：10.1007/s11064-020-03157-1
影響因子 ：4.4
引用產(chǎn)品： SK-N-SH 細(xì)胞 , 293T [HEK-293T] 細(xì)胞 , 青霉素-鏈霉素溶液 (雙抗)，100×
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