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產(chǎn)品概述
| 名稱 | HTR-8-Svneo (人絨毛膜滋養(yǎng)層細胞) (STR鑒定正確) |
| 別稱 | HTR-8/SV neo; HTR-8/SV-neo; HTR8/SVneo; HTR8svn |
| 種屬 | 人 |
| 生長特性 | 貼壁細胞 |
| 細胞形態(tài) | 上皮細胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:3 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | The HTR-8-Svneo cell line was derived by transfecting the cells that grew out of chorinic villi explants of human first-trimester placenta with the gene encoding for simian virus 40 large T antigen. |
| 年齡（性別） | 女性；6-12周齡胚胎 |
| 組織來源 | 胎盤 |
| 細胞類型 | 轉(zhuǎn)化細胞系 |
| 生物安全等級 | BSL-1 |
| 致瘤性 | No (tested in soft agar and nude mice). |
| 抗原表達情況 | cytokeratin-7+; insulin-like growth factor (IGF)-II+; NDOG-5 (placental alkaline phosphatase (PLAP) antibody) +; proliferating cell nuclear antigen (PCNA)+; human leukocyte antigen framework antigen (W6/32)+; integrin subunits alpha 1, alpha 3, alpha |
| 保藏機構(gòu) | ATCC; CRL-3271 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 12 D2S1338 23,24 D3S1358 16 D5S818 12 D7S820 12 D8S1179 12,15 D13S317 9,12 D16S539 11,13 D18S51 13 D19S433 14,15 D21S11 29,30 FGA 21,23 PentaD 9,12 PentaE 7,17 TH01 6,9.3 TPOX 8 vWA 13,18 D6S1043 14,19 D12S391 19 D2S441 11 -
STR鑒定圖
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參考文獻
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Methionine regulates maternal-fetal immune tolerance and endometrial receptivity by enhancing embryonic IL-5 secretion (2025-02-11)
期刊：Cell Reports
DOI：10.1016/j.celrep.2025.115291
影響因子 ：7.5
引用產(chǎn)品： 人子宮內(nèi)膜上皮細胞 , HTR-8-Svneo 細胞
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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation (2025-01-16)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2025.117728
影響因子 ：6.2
引用產(chǎn)品： HTR-8-Svneo 細胞 , RPMI-1640 培養(yǎng)基 , 特級胎牛血清
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Ferroptosis-related genes in preeclampsia: integrative bioinformatics analysis, experimental validation and drug prediction (2025-02-21)
期刊：BMC Pregnancy and Childbirth
DOI：10.1186/s12884-025-07325-5
影響因子 ：2.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway (2024-01-04)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04831-y
影響因子 ：7.4
引用產(chǎn)品： HTR-8-Svneo 細胞 , JEG-3 細胞 , THP-1 細胞 , RAW 264.7 細胞
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MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis (2024-12-22)
期刊：Biology Direct
DOI：10.1186/s13062-024-00572-0
影響因子 ：5.7
引用產(chǎn)品： HTR-8-Svneo 細胞
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Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus (2024-11-15)
期刊：World Journal of Diabetes
影響因子 ：4.2
引用產(chǎn)品： HTR-8-Svneo 細胞 , RPMI-1640 培養(yǎng)基
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Inhibition of the endoplasmic reticulum stress-associated IRE-1 pathway alleviates preterm birth (2024-03-26)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：3.6
引用產(chǎn)品： HTR-8-Svneo 細胞
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NANOG regulate the JAK/STAT3 pathway to promote trophoblast cell migration and epithelial-mesenchymal transition (EMT) in hypertensive disorders of pregnancy (HDP) through protein interaction with CDK1 (2024-05-26)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：3.6
引用產(chǎn)品： HTR-8-Svneo 細胞
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LIM homeobox 1 (LHX1) induces endoplasmic reticulum stress and promotes preterm birth (2024-06-19)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e32457
影響因子 ：3.4
引用產(chǎn)品： HTR-8-Svneo 細胞
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SIRT5 suppresses the trophoblast cell proliferation, invasion, and migration to promote preeclampsia via desuccinylating HOXB3 (2024-08-15)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-024-03223-5
影響因子 ：3.2
引用產(chǎn)品： 青霉素-鏈霉素溶液（雙抗），100× , HTR-8-Svneo 細胞 , RPMI-1640 完全培養(yǎng)基（含10% FBS）
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Mechanisms of YAP1-mediated trophoblast ferroptosis in recurrent pregnancy loss (2024-03-25)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-024-03096-8
影響因子 ：3.1
引用產(chǎn)品： HTR-8-Svneo 細胞 , JAR 細胞
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Establishment of a placental lncRNA-mRNA expression network for early-onset preeclampsia (2024-04-27)
期刊：BMC Pregnancy and Childbirth
DOI：10.1186/s12884-024-06481-4
影響因子 ：3.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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MiR-135a-5p regulates window of implantation by suppressing pinopodes development and decidualization of endometrial stromal cells (2024-03-21)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-024-03088-8
影響因子 ：3.1
引用產(chǎn)品： HTR-8-Svneo 細胞 , 293T [HEK-293T] 細胞 , 青霉素-鏈霉素溶液 (雙抗)，100×
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Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia (2024-07-29)
期刊：PLACENTA
DOI：10.1016/j.placenta.2024.07.311
影響因子 ：3.0
引用產(chǎn)品： HTR-8-Svneo 細胞
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KLF15 alleviates oxidative stress and apoptosis of H/R-induced trophoblast cells to improve invasion and migration capacity via the activation of IGF1R (2024-07-20)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2024.102485
影響因子 ：2.7
引用產(chǎn)品： HTR-8-Svneo 細胞
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Circ-ADAM9 Knockdown Reduces Insulin Resistance and Placental Injury in Diabetic Mice via MAPK Pathway Inactivation (2024-11-22)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：2.5
引用產(chǎn)品： HTR-8-Svneo 細胞
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Screening Preeclampsia Genes and the Effects of CITED2 on Trophoblastic Function (2024-08-13)
期刊：International Journal of General Medicine
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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miR-942-5p Regulates Proliferation, Invasion and EMT of Trophoblast Cells in Gestational Diabetes by Targeting the CEBPA (2024-01-01)
期刊：ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
DOI：PMID:38290456
影響因子 ：1.9
引用產(chǎn)品： HTR-8-Svneo 細胞 , 293T [HEK-293T] 細胞
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The Deubiquitinating Enzyme USP4 Promotes Trophoblast Dysfunction by Stabilizing RYBP (2024-10-15)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01525-0
影響因子 ：1.8
引用產(chǎn)品： JEG-3 細胞 , HTR-8-Svneo 細胞 , JEG-3細胞專用培養(yǎng)基 , HTR-8-Svneo細胞專用培養(yǎng)基
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Lingguizhugan decoction alleviates gestational diabetes mellitus by modulating the PI3K–AKT pathway and oxidative stress: Network pharmacology and experimental evidence (2024-11-12)
期刊：BIOMEDICAL CHROMATOGRAPHY
DOI：10.1002/bmc.6042
影響因子 ：1.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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Protective Effects of Paeoniflorin Against Inflammation and Oxidative Stress in Rats with Gestational Diabetes Mellitus via Inhibiting the RhoA/ROCK Signaling Pathway (2024-01-02)
期刊：Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
DOI：10.1007/s43450-023-00505-4
影響因子 ：1.6
引用產(chǎn)品： HTR-8-Svneo 細胞
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Calcium/calmodulin dependent protein kinase IV in trophoblast cells under insulin resistance: functional and metabolomic analyses (2023-06-29)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-023-00669-8
影響因子 ：5.7
引用產(chǎn)品： HTR-8-Svneo 細胞
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USP17 regulates preeclampsia by modulating the NF-κB signaling pathway via deubiquitinating HDAC2 (2023-11-21)
期刊：PLACENTA
DOI：10.1016/j.placenta.2023.11.010
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞 , 293T [HEK-293T] 細胞 , RPMI-1640 培養(yǎng)基 , DMEM高糖 培養(yǎng)基
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Aspirin protects human trophoblast HTR-8/SVneo cells from H2O2-Induced oxidative stress via NADPH/ROS pathway (2023-11-18)
期刊：PLACENTA
DOI：10.1016/j.placenta.2023.11.008
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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DNMT1 mediates proliferation, migration and invasion of extravillous trophoblasts by regulating the methylation level of APLNR (2023-05-03)
期刊：PLACENTA
DOI：10.1016/j.placenta.2023.05.001
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR-145-5p/TGFB2 axis (2023-01-20)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：3.6
引用產(chǎn)品： HTR-8-Svneo 細胞 , JAR 細胞 , JEG-3 細胞
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AQP9 causes recurrent spontaneous abortion by inhibiting trophoblast cell EMT and invasion through the PI3K/AKT pathway (2023-08-21)
期刊：BIOLOGY OF REPRODUCTION
影響因子 ：3.6
引用產(chǎn)品： HTR-8-Svneo 細胞 , JAR 細胞
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HNRNPC mediated m6A methylation of 5-Methyltetrahydrofolate-homocysteine methyltransferase and involved in the occurrence of recurrent spontaneous abortion (2023-10-04)
期刊：JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：3.4
引用產(chǎn)品： HTR-8-Svneo 細胞
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FtMt reduces oxidative stress-induced trophoblast cell dysfunction via the HIF-1α/VEGF signaling pathway (2023-03-01)
期刊：BMC Pregnancy and Childbirth
DOI：10.1186/s12884-023-05448-1
影響因子 ：3.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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Maternal circulating exosomal miR-185-5p levels as a predictive biomarker in patients with recurrent pregnancy loss (2023-02-06)
期刊：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
DOI：10.1007/s10815-023-02733-y
影響因子 ：3.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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Reversal of H2O2-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis (2023-05-15)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-023-01070-8
影響因子 ：2.9
引用產(chǎn)品： HTR-8-Svneo 細胞
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Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes (2023-12-05)
期刊：PeerJ
影響因子 ：2.7
引用產(chǎn)品： A549 [A-549] 細胞 , HTR-8-Svneo 細胞 , HuH-7 細胞 , Ham's F-12K 培養(yǎng)基
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Downregulation of BRD4 attenuates high glucose-induced damage of trophoblast cells by inhibiting activation of AKT/mTOR pathway (2023-03-03)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2023.100751
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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circ_0014736 induces GPR4 to regulate the biological behaviors of human placental trophoblast cells through miR-942-5p in preeclampsia (2023-03-01)
期刊：Open Medicine
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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MicroRNA-206 Contributes to the Progression of Preeclampsia by Suppressing the Viability and Mobility of Trophocytes via the Inhibition of AGTR1 (2023-10-31)
期刊：PHYSIOLOGICAL RESEARCH
DOI：10.33549/physiolres.935131
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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Knockdown of TXNIP alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts (2023-12-19)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2023.100841
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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COLEC12 expression participates in trophoblast insulin resistance, and reverses celecoxib-mediated inhibition of COX2-PGE2 axis in gestational diabetes (2023-06-05)
期刊：TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
影響因子 ：0.6
引用產(chǎn)品： HTR-8-Svneo 細胞
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Forkhead-box C1 attenuates high glucose-induced trophoblast cell injury during gestational diabetes mellitus via activating adenosine monophosphate-activated protein kinase through regulating fibroblast growth factor 19 (2022-01-04)
期刊：Bioengineered
DOI：10.1080/21655979.2021.2018094
影響因子 ：4.9
引用產(chǎn)品： HTR-8-Svneo 細胞
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Circ_0111277 suppresses trophoblast cell proliferation, angiogenesis, migration, invasion and EMT via regulating miR-188-3p/GRHL2 axis (2022-11-21)
期刊：AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞 , HTR-8-Svneo細胞專用培養(yǎng)基 , 人臍靜脈內(nèi)皮細胞
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Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis (2022-03-03)
期刊：Biology Of Reproduction
影響因子 ：3.6
引用產(chǎn)品： HTR-8-Svneo 細胞 , PUMC-HUVEC-T1
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IL?1β?induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL?1β antagonists (2022-02-07)
期刊：Molecular Medicine Reports
影響因子 ：3.4
引用產(chǎn)品： JEG-3 細胞 , HTR-8-Svneo 細胞
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Di-2-ethylhexyl phthalate-induced miR-155–5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells (2022-10-04)
期刊：REPRODUCTIVE TOXICOLOGY
DOI：10.1016/j.reprotox.2022.10.001
影響因子 ：3.4
引用產(chǎn)品： HTR-8/Svneo 細胞
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miR-2115-3p inhibits ferroptosis by downregulating the expression of glutamic-oxaloacetic transaminase in preeclampsia (2022-10-10)
期刊：PLACENTA
DOI：10.1016/j.placenta.2022.09.014
影響因子 ：3.3
引用產(chǎn)品： HTR-8-Svneo 細胞
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SKAP2 is downregulated in the villous tissues of patients with missed abortion and regulates growth and migration in trophoblasts through the WAVE2-ARP2/3 signaling pathway (2022-09-05)
期刊：PLACENTA
DOI：10.1016/j.placenta.2022.08.061
影響因子 ：3.3
引用產(chǎn)品： RPMI-1640 培養(yǎng)基 , HTR-8-Svneo 細胞 , 青霉素-鏈霉素溶液（雙抗），100× , 特級胎牛血清
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Silencing of LncRNA SNHG6 protects trophoblast cells through regulating miR-101-3p/OTUD3 axis in unexplained recurrent spontaneous abortion (2022-09-29)
期刊：JOURNAL OF MOLECULAR HISTOLOGY
DOI：10.1007/s10735-022-10102-9
影響因子 ：3.2
引用產(chǎn)品： HTR-8-Svneo 細胞
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Identification of Circular RNA circ_0017068 as a Regulator of Proliferation and Apoptosis in Trophoblast Cells by miR-330-5p/XIAP Axis (2022-01-03)
期刊：Reproductive Sciences
DOI：10.1007/s43032-021-00827-5
影響因子 ：2.9
引用產(chǎn)品： HTR-8-Svneo 細胞
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Circ_FOXP1 promotes the growth and survival of high glucose-treated human trophoblast cells through the regulation of miR-508-3p/SMAD family member 2 pathway (2022-09-28)
期刊：ENDOCRINE JOURNAL
影響因子 ：2.9
引用產(chǎn)品： HTR-8-Svneo 細胞
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LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-κB pathway (2022-10-31)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100696
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞 , 293 [HEK-293] 細胞
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Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells (2021-06-08)
期刊：Frontiers in Endocrinology
影響因子 ：5.2
引用產(chǎn)品： HTR-8-Svneo 細胞
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MiR-296-3p promotes the development and progression of preeclampsia via targeting the CEMIP (2021-06-01)
期刊：European Review for Medical and Pharmacological Sciences
DOI：10.26355/eurrev_202106_26034
影響因子 ：3.8
引用產(chǎn)品： JAR 細胞 , HTR-8-Svneo 細胞
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Puerarin attenuates preeclampsia-induced trophoblast mobility loss and inflammation by modulating miR-181b-5p/RBAK axis (2021-12-07)
期刊：American Journal Of Reproductive Immunology
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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LncRNA XIST serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell via miR-497-5p/FOXO1 axis (2021-06-01)
期刊：Cardiovascular Diagnosis and Therapy
影響因子 ：2.4
引用產(chǎn)品： HTR-8-Svneo 細胞
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LncRNA OIP5-AS1 Signatures as a Biomarker of Gestational Diabetes Mellitus and a Regulator on Trophoblast Cells (2021-11-29)
期刊：Gynecologic And Obstetric Investigation
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞
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Circular RNA circ_0032962 promotes trophoblast cell progression as ceRNA to target PBX3 via sponging miR-326 in preeclampsia (2021-11-03)
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2021.100571
影響因子 ：2.1
引用產(chǎn)品： HTR-8-Svneo 細胞 , HTR-8-Svneo細胞專用培養(yǎng)基
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Rhynchophylline improves trophocyte mobility potential by upregulating ZEB1 level via the inhibition of miR-141-3p level (2021-01-28)
期刊：Bioscience Biotechnology and Biochemistry
影響因子 ：1.6
引用產(chǎn)品： HTR-8-Svneo 細胞
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Integrin β1 regulates proliferation, apoptosis, and migration of trophoblasts through activation of phosphoinositide 3 kinase/protein kinase B signaling (2021-04-11)
期刊：Journal Of Obstetrics And Gynaecology Research
影響因子 ：1.6
引用產(chǎn)品： IMDM完全培養(yǎng)基 (含10%FBS) , HTR-8-Svneo 細胞
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The regulatory network of lncRNA DLX6-AS1/miR-149–5p/ERP44 is possibly related to the progression of preeclampsia (2020-02-04)
期刊：Placenta
DOI：10.1016/j.placenta.2020.02.001
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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CircLRRK1 targets miR-223-3p to inhibit the proliferation, migration and invasion of trophoblast cells by regulating the PI3K/AKT signaling pathway (2020-12-07)
期刊：Placenta
DOI：10.1016/j.placenta.2020.12.003
影響因子 ：3.8
引用產(chǎn)品： HTR-8-Svneo 細胞
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The role of Smad4 in the regulation of insulin resistance, inflammation and cell proliferation in HTR8‐Svneo cells (2020-10-20)
期刊：Cell Biochemistry and Function
DOI：10.1002/cbf.3594
影響因子 ：3.6
引用產(chǎn)品： HTR-8-Svneo 細胞
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