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產(chǎn)品概述
| 名稱 | H22 (小鼠肝癌細胞) (STR鑒定正確) |
| 別稱 | Hepatoma-22; Hepatoma 22 |
| 種屬 | 小鼠 |
| 生長特性 | 懸浮細胞 |
| 細胞形態(tài) | 淋巴母細胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認） |
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 3×10^5-5×10^5cells/mL |
| 推薦換液頻率 | 2-3次/周 |
| 注意事項 | H22細胞是小鼠腹水瘤細胞，體外培養(yǎng)傳代4-5代左右，細胞活力會將低，狀態(tài)會變差，可通過腹水培養(yǎng)恢復(fù)細胞活力。該細胞為懸浮細胞，請注意離心收集細胞懸液；請勿直接倒掉細胞培養(yǎng)液。 |
| 背景描述 | H22細胞是分離自小鼠腹水，由大連醫(yī)科學(xué)院建立。 |
| 年齡（性別） | 不詳 |
| 組織來源 | 肝；肝癌 |
| 細胞類型 | 腫瘤細胞 |
| 腫瘤類型 | 肝膽癌細胞 |
STR鑒定
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STR位點信息
18-3 11,17 6-7 13 5-5 14 X-1 25 1-2 18,19 7-1 24.2 8-1 17,18 1-1 15,16 19-2 13 15-3 19.3,20.3,25.3 12-1 17 6-4 15.3,16.3 4-2 19.3,20.3 3-2 13,14 2-1 9 13-1 16.2
11-2 16 17-2 13,15 -
STR鑒定圖
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參考文獻
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Self-assembling chemodrug fiber-hydrogel for transarterial chemoembolization and radiotherapy-enhanced antitumor immunity (2025-02-03)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2025.01.088
影響因子 ：10.5
引用產(chǎn)品： H22 細胞
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Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinoma (2025-02-01)
期刊：Journal for ImmunoTherapy of Cancer
影響因子 ：10.3
引用產(chǎn)品： Hepa 1-6 細胞 , HePa1-6-LUC 細胞 , H22 細胞 , 293T [HEK-293T] 細胞
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Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy (2025-01-06)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1503490
影響因子 ：4.4
引用產(chǎn)品： 丙酮酸鈉溶液（100 mM），100× , H22 細胞 , HuH-7 細胞
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Preparation of oat galactolipid and anti-liver cancer effects of oat galactolipid–modified curcumin-loaded liver targeting vesicle (2025-01-08)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1511666
影響因子 ：4.4
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Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur (2025-01-29)
期刊：Scientific Reports
DOI：10.1038/s41598-024-83530-0
影響因子 ：3.8
引用產(chǎn)品： H22 細胞
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Intracellular Magnetic Hyperthermia Sensitizes Sorafenib to Orthotopic Hepatocellular Carcinoma Via Amplified Ferroptosis (2024-10-21)
期刊：ACS Nano
影響因子 ：15.8
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Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization (2024-04-15)
期刊：Aggregate
DOI：10.1002/agt2.552
影響因子 ：13.9
引用產(chǎn)品： H22 細胞
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Natural diterpene carrier-free hydrogel enhances antigen presentation and intensifies T cell activation for tumor immunotherapy (2024-10-19)
期刊：CHEMICAL ENGINEERING JOURNAL
影響因子 ：13.3
引用產(chǎn)品： H22 細胞
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Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma (2024-02-02)
期刊：MOLECULAR THERAPY
DOI：10.1016/j.ymthe.2024.01.032
影響因子 ：12.4
引用產(chǎn)品： H22 細胞
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MATR3 Promotes Liver Cancer Progression by Suppressing DHX58–Mediated Type I Interferon Response (2024-09-12)
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2024.217231
影響因子 ：9.1
引用產(chǎn)品： Hep G2 細胞 , H22 細胞 , 293T [HEK-293T] 細胞 , Hepa 1-6 細胞
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The combination of Brassica rapa L. polysaccharides and cisplatin enhances the anti liver cancer effect and improves intestinal microbiota and metabolic disorders (2024-03-07)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2024.130706
影響因子 ：8.2
引用產(chǎn)品： H22 細胞
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Propylene glycol alginate sodium sulfate suppressed lung metastasis by blocking P-selectin to recruit CD4 regulatory T cells (2024-08-22)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2024.134976
影響因子 ：7.7
引用產(chǎn)品： H22 細胞
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B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4+T cell cytotoxicity through ESM1 (2024-07-01)
期刊：npj Precision Oncology
DOI：10.1038/s41698-024-00625-7
影響因子 ：6.8
引用產(chǎn)品： Hepa 1-6 細胞 , H22 細胞 , Hep53.4 細胞 , Hep 3B2.1-7 細胞
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A pH-Responsive Drug-Delivery System Based on Apatinib-Loaded Metal-Organic Frameworks for Ferroptosis-Targeted Synergistic Anti-Tumor Therapy (2024-09-04)
期刊：International Journal of Nanomedicine
影響因子 ：6.6
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Glycyrrhizic Acid-Based Liposome for Tumor-Targeted Delivery of Cantharidin (2024-01-02)
期刊：ACS Applied Nano Materials
影響因子 ：5.9
引用產(chǎn)品： H22 細胞
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Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity (2024-01-28)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111553
影響因子 ：5.6
引用產(chǎn)品： H22 細胞
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Pathogenic Th17 cell-mediated liver fibrosis contributes to resistance to PD-L1 antibody immunotherapy in hepatocellular carcinoma (2024-02-13)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111601
影響因子 ：5.6
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Dietary supplementation of α-linolenic acid-rich flaxseed oil enhances anti-PD-1 protection against orthotopic hepatocellular carcinoma by reshaping gut homeostasis and improving anti-tumor immunity via gut-liver axis in mice (2024-04-01)
期刊：Journal of Functional Foods
影響因子 ：5.6
引用產(chǎn)品： H22 細胞
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Co-delivery of SN38 and MEF2D-siRNA via tLyp-1-modified liposomes reverses PD-L1 expression induced by STING activation in hepatocellular carcinoma (2024-10-13)
期刊：COLLOIDS AND SURFACES B-BIOINTERFACES
DOI：10.1016/j.colsurfb.2024.114318
影響因子 ：5.4
引用產(chǎn)品： RAW 264.7 細胞 , H22 細胞 , Hepa 1-6 細胞
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Dual Targeted Nanoparticles Encapsulating Cantharidin for Treatment of Hepatocellular Carcinoma and Lymphatic Metastasis (2024-08-29)
期刊：ACS Applied Nano Materials
影響因子 ：5.3
引用產(chǎn)品： H22 細胞
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Investigation on the mechanisms of scorpion venom in hepatocellular carcinoma model mice via untargeted metabolomics profiling (2024-07-02)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.112578
影響因子 ：4.8
引用產(chǎn)品： H22 細胞 , 青霉素-鏈霉素溶液（雙抗），100×
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Oxymatrine Inhibits PD-L1 by Downregulating IFN-γ to Promote Ferroptosis and Enhance Anti-PD-L1 Efficacy in Liver Cancer (2024-12-06)
期刊：Journal of Hepatocellular Carcinoma
影響因子 ：4.2
引用產(chǎn)品： Hep G2 細胞 , MHCC97-L 細胞 , H22 細胞 , DMEM高糖 培養(yǎng)基 , RPMI-1640 培養(yǎng)基 , 特級胎牛血清
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CD36-mediated accumulation of MDSCs exerts abscopal immunosuppressive responses in hepatocellular carcinoma after insufficient microwave ablation (2024-09-02)
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2024.167493
影響因子 ：4.2
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Green Synthesis of Gold Nanoparticles from Polygahatous Polysaccharides and Their Anticancer Effect on Hepatic Carcinoma through Immunoregulation (2024-05-02)
期刊：ACS Omega
影響因子 ：4.1
引用產(chǎn)品： DMEM高糖完全培養(yǎng)基（含10% FBS） , H22 細胞
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Paeoniflorin increases the anti-tumor efficacy of sorafenib in tumor-bearing mice with liver cancer via suppressing the NF-κb/PD-l1 axis (2024-01-13)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e24461
影響因子 ：4.0
引用產(chǎn)品： H22 細胞
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DSN1 Interaction With Centromere-Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma (2024-11-19)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23845
影響因子 ：3.0
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Yangzheng mixture reversed EMT against hepatocellular carcinoma metastasis via NF-κB/NLRP3/β-catenin pathway (2024-09-03)
期刊：TOXICON
DOI：10.1016/j.toxicon.2024.108090
影響因子 ：2.6
引用產(chǎn)品： H22 細胞
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Protocol for screening potential targets for the treatment of hepatocellular carcinoma based on H22 tumor-bearing mouse model (2024-10-17)
期刊：STAR Protocols
DOI：10.1016/j.xpro.2024.103193
影響因子 ：1.3
引用產(chǎn)品： H22 細胞
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Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions (2023-04-17)
期刊：Journal of Advanced Research
DOI：10.1016/j.jare.2023.04.008
影響因子 ：10.7
引用產(chǎn)品： H22 細胞
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pH-triggered dynamic erosive small molecule chlorambucil nano-prodrugs mediate robust oral chemotherapy (2023-07-25)
期刊：Asian Journal of Pharmaceutical Sciences
DOI：10.1016/j.ajps.2023.100832
影響因子 ：10.2
引用產(chǎn)品： Hep G2 細胞 , H22 細胞 , MCF7 [MCF-7] 細胞 , K-562 [K562] 細胞 , A549 [A-549] 細胞
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Nanoparticles prepared by polysaccharides extracted from Biyang floral mushroom loaded with resveratrol: Characterization, bioactivity and release behavior under in vitro digestion (2023-06-12)
期刊：FOOD CHEMISTRY
DOI：10.1016/j.foodchem.2023.136612
影響因子 ：8.8
引用產(chǎn)品： H22 細胞
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Huaier improves the efficacy of anti-PD-L1 Ab in the treatment of hepatocellular carcinoma by regulating tumor immune microenvironment (2023-11-04)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.155189
影響因子 ：7.9
引用產(chǎn)品： H22 細胞
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Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota (2023-12-20)
期刊：Food & Function
影響因子 ：6.1
引用產(chǎn)品： H22 細胞
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Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma (2023-08-21)
期刊：Food & Function
影響因子 ：6.1
引用產(chǎn)品： H22 細胞
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Antitumor Activity of Carboxymethyl Pachymaran with Different Molecular Weights Based on Immunomodulatory and Gut Microbiota (2023-10-25)
期刊：Nutrients
影響因子 ：5.9
引用產(chǎn)品： H22 細胞
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Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma (2023-03-07)
期刊：Cancer Nanotechnology
DOI：10.1186/s12645-023-00166-x
影響因子 ：5.7
引用產(chǎn)品： H22 細胞
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Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma (2023-01-11)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影響因子 ：5.6
引用產(chǎn)品： H22 細胞
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Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence (2023-09-27)
期刊：Drug Delivery and Translational Research
DOI：10.1007/s13346-023-01433-5
影響因子 ：5.4
引用產(chǎn)品： H22 細胞
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Astaxanthin Supplementation Assists Sorafenib in Slowing Skeletal Muscle Atrophy in H22 Tumor-Bearing Mice via Reversing Abnormal Glucose Metabolism (2023-05-13)
期刊：MOLECULAR NUTRITION & FOOD RESEARCH
影響因子 ：5.2
引用產(chǎn)品： H22 細胞
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Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment (2023-12-07)
期刊：MOLECULAR NUTRITION & FOOD RESEARCH
影響因子 ：5.2
引用產(chǎn)品： H22 細胞 , Hepa 1-6 細胞 , BEL-7402 細胞 , 人臍靜脈內(nèi)皮細胞 , HuH-7 細胞
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Comparative transcriptome and proteome analysis explores the antitumor key regulators of ergosterone in H22 tumor-bearing mice (2023-06-07)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.175831
影響因子 ：5.0
引用產(chǎn)品： H22 細胞
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Comparative study on the anti-tumor effect of steroids derived from different organisms in H22 tumor-bearing mice and analysis of their mechanisms (2023-12-13)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.176269
影響因子 ：5.0
引用產(chǎn)品： H22 細胞
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CDK1-SRC Interaction-Dependent Transcriptional Activation of HSP90AB1 Promotes Antitumor Immunity in Hepatocellular Carcinoma (2023-11-10)
期刊：JOURNAL OF PROTEOME RESEARCH
DOI：10.1021/acs.jproteome.3c00379
影響因子 ：4.4
引用產(chǎn)品： HuH-7 細胞 , H22 細胞 , 特級胎牛血清 , 青霉素-鏈霉素溶液 (雙抗)，100× , DMEM高糖 培養(yǎng)基
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Ajmalicine induces the pyroptosis of hepatoma cells to exert the antitumor effect (2023-12-08)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影響因子 ：3.6
引用產(chǎn)品： H22 細胞
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A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury (2023-05-05)
期刊：Recent Patents on Anti-Cancer Drug Discovery
DOI：10.2174/1574892818666230417093208
影響因子 ：2.8
引用產(chǎn)品： H22 細胞
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ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression (2022-08-01)
期刊：International Journal of Biological Sciences
影響因子 ：10.8
引用產(chǎn)品： HuH-7 細胞 , Hep 3B2.1-7 細胞 , SK-Hep-1 細胞 , Hep G2 細胞 , H22 細胞 , THP-1 細胞
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer (2022-12-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-022-01738-6
影響因子 ：9.4
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Lactose-modified enzyme-sensitive branched polymers as a nanoscale liver cancer-targeting MRI contrast agent (2022-12-12)
期刊：Nanoscale
影響因子 ：8.3
引用產(chǎn)品： H22 細胞
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Improved anti-hepatocellular carcinoma effect by enhanced Co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles (2022-07-06)
期刊：Materials Today Bio
DOI：10.1016/j.mtbio.2022.100350
影響因子 ：8.2
引用產(chǎn)品： Hepa 1-6 細胞 , H22 細胞
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Fluorinated carboxymethyl chitosan-based nano-prodrugs for precisely synergistic chemotherapy (2022-12-20)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2022.12.157
影響因子 ：8.0
引用產(chǎn)品： H22 細胞 , Hep G2 細胞 , A549 [A-549] 細胞 , MCF7 [MCF-7] 細胞
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Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice (2022-12-05)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影響因子 ：5.2
引用產(chǎn)品： H22 細胞
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Quercetin, the Ingredient of Xihuang Pills, Inhibits Hepatocellular Carcinoma by Regulating Autophagy and Macrophage Polarization (2022-12-20)
期刊：Frontiers in Bioscience-Landmark
影響因子 ：3.1
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Effects of Sensitized Sorafenib with a Paeoniflorin and Geniposide Mixture on Liver Cancer via the NF-κB-HIF-2α-SerpinB3 Pathway (2022-10-15)
期刊：Evidence-based Complementary and Alternative Medicine
影響因子 ：2.7
引用產(chǎn)品： H22 細胞
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Cantharidin-loaded biomimetic MOF nanoparticle cascade to enhance the Fenton reaction based on amplified photothermal therapy (2021-10-08)
期刊：Biomaterials Science
影響因子 ：7.6
引用產(chǎn)品： Hep G2 細胞 , RAW 264.7 細胞 , Hepa 1-6 細胞 , H22 細胞
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Protective effects of low-temperature plasma on cisplatin-induced nephrotoxicity (2021-12-14)
期刊：Life Sciences
影響因子 ：6.1
引用產(chǎn)品： H22 細胞
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Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic (2021-12-11)
期刊：Journal Of Ethnopharmacology
影響因子 ：5.4
引用產(chǎn)品： H22 細胞
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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D (2021-07-02)
期刊：Journal of Immunology Research
影響因子 ：4.5
引用產(chǎn)品： HL-7702 [L-02; LO2] , SMMC-7721 細胞 , Hep G2 細胞 , H22 細胞
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Cistanche tubulosa Phenylethanoid Glycosides Induce Apoptosis of Hepatocellular Carcinoma Cells by Mitochondria-Dependent and MAPK Pathways and Enhance Antitumor Effect through Combination with Cisplatin: (2021-05-05)
期刊：Integrative Cancer Therapies
影響因子 ：2.9
引用產(chǎn)品： H22 細胞
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Ultrasound Molecular Imaging as a Potential Non-invasive Diagnosis to Detect the Margin of Hepatocarcinoma via CSF-1R Targeting (2020-07-14)
期刊：FRONT BIOENG BIOTECH
影響因子 ：5.7
引用產(chǎn)品： H22 細胞
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Radiosensitization potential of caffeic acid phenethyl ester and the long non-coding RNAs in response to 60Coγ radiation in mouse hepatoma cells (2020-12-24)
期刊：Radiation Physics and Chemistry
DOI：10.1016/j.radphyschem.2020.109326
影響因子 ：2.9
引用產(chǎn)品： H22 細胞
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Antitumor Effects of Curcumin and Glycyrrhetinic Acid-Modified Curcumin-Loaded Cationic Liposome by Intratumoral Administration (2020-05-30)
期刊：Evidence-Based Complementary and Alternative Medicine
影響因子 ：2.7
引用產(chǎn)品： H22 細胞
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Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells (2019-10-31)
期刊：Gastroenterology
DOI：10.1053/j.gastro.2019.10.025
影響因子 ：29.4
引用產(chǎn)品： H22 細胞 , Hepa 1-6 細胞
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Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells (2019-04-23)
期刊：Nanoscale
影響因子 ：6.7
引用產(chǎn)品： H22 細胞
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EGCG enhances cancer cells sensitivity under 60Coγ radiation based on miR-34a/Sirt1/p53 (2019-09-05)
期刊：Food And Chemical Toxicology
影響因子 ：4.3
引用產(chǎn)品： H22 細胞
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![EMT6 [EMT-6] (小鼠乳腺癌細胞) (STR鑒定正確)](/Public/upfile/pic/xbx/CL-0573-1.jpg)
