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產(chǎn)品概述
名稱 | NCI-H446 [H446] (人小細(xì)胞肺癌細(xì)胞) (STR鑒定正確) |
別稱 | H446; H-446; NCI-446; NCIH446 |
種屬 | 人 |
生長(zhǎng)特性 | 半貼半懸 |
細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
凍存條件 | 凍存液:55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度:液氮 |
培養(yǎng)方案A(默認(rèn)) |
培養(yǎng)條件:
氣相:空氣,95%;CO2,5%, 溫度:37℃
|
推薦傳代比例 | 1:3-1:4 |
推薦換液頻率 | 2-3次/周 |
背景描述 | NCI-H446細(xì)胞是從一位小細(xì)胞肺癌患者的胸水中建立的,NCI-H446細(xì)胞的原始形態(tài)并不具有小細(xì)胞肺癌特征。NCI-H446細(xì)胞是小細(xì)胞肺癌的生化和形態(tài)學(xué)上的變種,表達(dá)神經(jīng)元特有的烯醇酶和腦部肌酸激酶同功酶。NCI-H446細(xì)胞內(nèi)左旋多巴脫羧酶、蠶素、抗利尿激素、催產(chǎn)素或胃泌激素釋放肽未達(dá)到可檢測(cè)水平。C-myc DNA序列擴(kuò)增約20倍,c-myc RNA比正常細(xì)胞增加15倍。最初,傳代培養(yǎng)基用RPMI-1640(含5%胎牛血清、10nM氫化可的松、0.005mg/ml胰島素、0.01mg/ml鐵傳遞蛋白、10nM 17-β-雌二醇、30nM亞硒酸鈉)。 |
年齡(性別) | 男性;61歲 |
組織來源 | 肺;轉(zhuǎn)移灶:肋膜滲出癌;小細(xì)胞肺癌 |
細(xì)胞類型 | 腫瘤細(xì)胞 |
腫瘤類型 | 肺癌細(xì)胞 |
生物安全等級(jí) | BSL-1 |
致瘤性 | Yes, in nude mice (The cells form transplantable tumors with non-typical SCLC histology). |
保藏機(jī)構(gòu) | ATCC; HTB-171 |
STR鑒定
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STR位點(diǎn)信息
Amelogenin X CSF1PO 13 D2S1338 18,20 D3S1358 17 D5S818 11 D7S820 10,11 D8S1179 13,15 D13S317 8 D16S539 12 D18S51 12,13 D19S433 13,14 D21S11 28 FGA 22 PentaD 12,13 PentaE 9,10 TH01 8,9.3 TPOX 9,11 vWA 18,19 D6S1043 11 D12S391 17,18 D2S441 10,11 -
STR鑒定圖
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參考文獻(xiàn)
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Effect of Astragalus Polysaccharide Combined with Cisplatin on Exhaled VOC Biomarkers in Lung Cancer and its Anticancer Mechanism (2025-02-20)
期刊:JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
DOI:10.1016/j.jpba.2025.116759
影響因子 :3.1
引用產(chǎn)品: 青霉素-鏈霉素溶液(雙抗),100× , LLC [LL/2; LLC1] 細(xì)胞 , BEAS-2B 細(xì)胞 , A549 [A-549] 細(xì)胞 , NCI-H446 [H446] 細(xì)胞
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Dynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer (2024-02-05)
期刊:Scientific Reports
DOI:10.1038/s41598-024-52687-z
影響因子 :4.6
引用產(chǎn)品: NCI-H69 細(xì)胞 , NCI-H2227 細(xì)胞 , H1092 細(xì)胞 , NCI-H446 [H446] 細(xì)胞 , 21H 細(xì)胞 , NCI-H196 細(xì)胞 , SBC-5 細(xì)胞 , HFL1 細(xì)胞
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Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents (2024-02-23)
期刊:PHARMACEUTICAL BIOLOGY
DOI:10.1080/13880209.2024.2318350
影響因子 :3.8
引用產(chǎn)品: NCI-H446 [H446] 細(xì)胞 , MCF7 [MCF-7] 細(xì)胞 , Hela 細(xì)胞 , A549 [A-549] 細(xì)胞 , HL-7702 [L-02; LO2] 細(xì)胞 , BEAS-2B 細(xì)胞
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NDRG2 acts as a negative regulator of the progression of small-cell lung cancer through the modulation of the PTEN-AKT-mTOR signalling cascade (2024-03-25)
期刊:TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI:10.1016/j.taap.2024.116915
影響因子 :3.8
引用產(chǎn)品: NCI-H446 [H446] 細(xì)胞 , NCI-H146 [H146] 細(xì)胞 , NCI-H209 [H209] 細(xì)胞 , DMS 114 細(xì)胞 , H1688 細(xì)胞
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Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade (2024-06-14)
期刊:TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI:10.1016/j.taap.2024.117005
影響因子 :3.3
引用產(chǎn)品: NCI-H146 [H146] 細(xì)胞 , NCI-H446 [H446] 細(xì)胞 , NCI-H209 [H209] 細(xì)胞 , NCI-H1688 細(xì)胞 , DMS 114 細(xì)胞
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Identification of volatile biomarkers for lung cancer from different histological sources: A comprehensive study (2024-03-31)
期刊:ANALYTICAL BIOCHEMISTRY
影響因子 :2.9
引用產(chǎn)品: A549 [A-549] 細(xì)胞 , NCI-H446 [H446] 細(xì)胞 , BEAS-2B 細(xì)胞
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Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene (2024-12-28)
期刊:HEREDITAS
DOI:10.1186/s41065-024-00360-w
影響因子 :2.1
引用產(chǎn)品: NCI-H446 [H446] 細(xì)胞 , HCC827 細(xì)胞 , A549 [A-549] 細(xì)胞 , A549/DDP 細(xì)胞
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Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer (2023-04-10)
期刊:ANTIOXIDANTS & REDOX SIGNALING
影響因子 :6.6
引用產(chǎn)品: A549 [A-549] 細(xì)胞 , NCI-H1299 細(xì)胞 , NCI-H446 [H446] 細(xì)胞 , LLC [LL/2; LLC1] 細(xì)胞
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Efficacy and mechanism study of cordycepin against brain metastases of small cell lung cancer based on zebrafish (2022-12-17)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2022.154613
影響因子 :6.7
引用產(chǎn)品: HITES細(xì)胞培養(yǎng)基 , NCI-H446 [H446] 細(xì)胞 , NCI-H69 細(xì)胞
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Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4, (2021-07-23)
期刊:Neoplasia
影響因子 :4.8
引用產(chǎn)品: NCI-H1299 細(xì)胞 , HCC827 細(xì)胞 , NCI-H1437 細(xì)胞 , NCI-H446 [H446] 細(xì)胞 , A549 [A-549] 細(xì)胞 , Ham's F-12K 培養(yǎng)基
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