HGF R/c-Met/HGFR (Glu25-Gly519), Human, Recombinant
英文名稱：HGF R/c-Met/HGFR (Glu25-Gly519), Human, Recombinant
貨號： PCK027
價(jià)格： ￥11880 ￥1880 ￥780 ￥17280
產(chǎn)品信息
| 產(chǎn)品形態(tài) | 粉末 |
| 產(chǎn)品規(guī)格 | 500μg / 50μg / 10μg / 1mg |
| 別名 | Hepatocyte Growth Factor Receptor;HGF Receptor;HGF/ SF Receptor;Proto-oncogene c-Met;Scatter factor Receptor;SF Receptor;Tyrosine- Protein kinase Met;MET |
| 物種 | 人 |
| 表達(dá)宿主 | Human Cells |
| 序列信息 | Glu25-Gly519 |
| 檢索號 | P08581 |
| 分子量 | 56.9 kDa |
| 表觀分子量 | 32&35-57 kDa |
| 標(biāo)簽 | C-6His |
| 純度 | > 95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | < 1.0 EU per 1 μg as determined by LAL test. |
| 儲(chǔ)存條件 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運(yùn)輸條件 | Ambient temperature or ice pack. |
| 有效期 | 12個(gè)月 |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 復(fù)融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 背景介紹 | Hepatocyte Growth Factor Receptor (HGF R) is a glycosylated Receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both Ligand binding and Receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells. |
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期刊：Regenerative Therapy
DOI：10.1016/j.reth.2024.05.002
影響因子：4.3
引用產(chǎn)品： HGF R/c-Met/HGFR (Glu25-Gly519), Human, Recombinant, TGFB1/TGFβ1/TGF-β1, Human, Recombinant
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