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Saos-2 (人成骨肉瘤細(xì)胞) (STR鑒定正確)
貨號：CL-0202
規(guī)格：1×10?cells/T25培養(yǎng)瓶
價格： ￥1600
生長培養(yǎng)基：McCoy’s 5A＋15% FBS＋1% P/S
產(chǎn)品概述
| 名稱 | Saos-2 (人成骨肉瘤細(xì)胞) (STR鑒定正確) |
| 別稱 | SAOS-2; Saos-2; SAOS 2; Saos 2; Saos2; SaOs2; SAOS2; Sarcoma OSteogenic-2; SaOS; SAOS |
| 種屬 | 人 |
| 生長特性 | 貼壁細(xì)胞 |
| 細(xì)胞形態(tài) | 上皮細(xì)胞樣 |
| 凍存條件 | 凍存液：55% 基礎(chǔ)培養(yǎng)基+40%FBS+5%DMSO 溫度：液氮 |
| 培養(yǎng)方案A（默認(rèn)） |
生長培養(yǎng)基:
培養(yǎng)條件:
氣相：空氣，95%；CO2，5%, 溫度：37℃
|
| 推薦傳代比例 | 1:2-1:3 |
| 推薦換液頻率 | 2-3次/周 |
| 背景描述 | Saos-2細(xì)胞是由J·Fogh和G·Trempe分離和鑒定的眾多人腫瘤細(xì)胞系中的一種。該病人曾經(jīng)多種藥物治療，包括RTG、methotrexate、adriamycin vincristine、cytoxan和aramycin-C。Saos-2細(xì)胞在免疫抑制小鼠中不致瘤，但在半固體培養(yǎng)基中形成集落。 |
| 年齡（性別） | 女性；11歲 |
| 組織來源 | 骨；骨肉瘤 |
| 細(xì)胞類型 | 腫瘤細(xì)胞 |
| 腫瘤類型 | 肉瘤細(xì)胞 |
| 生物安全等級 | BSL-1 |
| 倍增時間 | ~48 hours |
| 致瘤性 | No, The cells were not tumorigenic in immunosuppressed mice, but did form colonies in semisolid medium. |
| 受體表達(dá)情況 | epidermal growth factor (EGF); transforming growth factor beta (Type 1 and Type 2) |
| 抗原表達(dá)情況 | Blood Type B, Rh+; HLA A2, A3, Bw16, Bw47 |
| 保藏機(jī)構(gòu) | ATCC; CRL-7939ATCC; HTB-85 DSMZ; ACC-243 ECACC; 89050205 |
STR鑒定
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STR位點信息
Amelogenin X CSF1PO 10 D2S1338 18 D3S1358 18 D5S818 12 D7S820 8,10 D8S1179 10,12 D13S317 12,13 D16S539 12,13 D18S51 15 D19S433 13 D21S11 28,30 FGA 22,25 PentaD 11,12 PentaE 14,19 TH01 6,9 TPOX 8 vWA 18 D6S1043 11,14 D12S391 20 D2S441 10,14 -
STR鑒定圖
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參考文獻(xiàn)
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Single-Atom Cu Nanozyme-Loaded Bone Scaffolds for Ferroptosis-Synergized Mild Photothermal Therapy in Osteosarcoma Treatment (2024-02-29)
期刊：Advanced Healthcare Materials
影響因子 ：10.0
引用產(chǎn)品： Saos-2 細(xì)胞
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Single-cell and spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma (2024-05-17)
期刊：BMC Medicine
DOI：10.1186/s12916-024-03319-w
影響因子 ：9.3
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , 143B 細(xì)胞 , Saos-2 細(xì)胞
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Multi-omics analysis reveals cuproptosis and mitochondria-based signature for assessing prognosis and immune landscape in osteosarcoma (2024-01-05)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1280945
影響因子 ：7.3
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , HOS 細(xì)胞 , Saos-2 細(xì)胞 , 143B 細(xì)胞
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SNRNP70 regulates the splicing of CD55 to promote osteosarcoma progression (2024-12-20)
期刊：JCI Insight
DOI：10.1172/jci.insight.185269
影響因子 ：6.3
引用產(chǎn)品： MG-63 細(xì)胞 , Saos-2 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞
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CGREF1 modulates osteosarcoma proliferation by regulating the cell cycle through the Wnt/β-catenin signaling pathway (2024-12-20)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-024-01038-9
影響因子 ：6.0
引用產(chǎn)品： Saos-2 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , 143B 細(xì)胞 , MG-63 細(xì)胞
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Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway (2024-01-08)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-024-00778-y
影響因子 ：5.7
引用產(chǎn)品： U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞 , MG-63 細(xì)胞
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Comprehensive investigation of tumor immune microenvironment and prognostic biomarkers in osteosarcoma through integrated bulk and single-cell transcriptomic analysis (2024-07-23)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2024.1424950
影響因子 ：5.7
引用產(chǎn)品： Saos-2 細(xì)胞 , MG-63 細(xì)胞
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Sirtuin 3-activated superoxide dismutase 2 mediates fluoride-induced osteoblastic differentiation in vitro and in vivo by down-regulating reactive oxygen species (2024-07-16)
期刊：ARCHIVES OF TOXICOLOGY
DOI：10.1007/s00204-024-03819-x
影響因子 ：4.8
引用產(chǎn)品： McCoy's 5A 培養(yǎng)基 , MG-63 細(xì)胞 , Saos-2 細(xì)胞 , MG-63細(xì)胞專用培養(yǎng)基
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IMPC-based screening revealed that ROBO1 can regulate osteoporosis by inhibiting osteogenic differentiation (2024-10-08)
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2024.1450215
影響因子 ：4.6
引用產(chǎn)品： Saos-2 細(xì)胞 , 小鼠骨髓間充質(zhì)干細(xì)胞 , MC3T3-E1 Subclone 14 細(xì)胞
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CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA (2024-04-16)
期刊：PLoS One
DOI：10.1371/journal.pone.0298947
影響因子 ：3.7
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , Saos-2 細(xì)胞
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Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma (2024-02-27)
期刊：Cancer Biomarkers
影響因子 ：2.2
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , HOS 細(xì)胞 , Saos-2 細(xì)胞 , 特級胎牛血清 , McCoy's 5A 培養(yǎng)基 , DMEM高糖 培養(yǎng)基 , Leibovitz's L-15 培養(yǎng)基
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MiR-150-5p inhibits cell proliferation and metastasis by targeting FTO in osteosarcoma (2024-10-16)
期刊：ONCOLOGY RESEARCH
影響因子 ：2.0
引用產(chǎn)品： MG-63 細(xì)胞 , HOS 細(xì)胞 , Saos-2 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , hFOB 1.19 細(xì)胞
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LncRNA SNHG25 Predicts Poor Prognosis and Promotes Progression in Osteosarcoma via the miR-497-5p/SOX4 Axis (2024-03-01)
期刊：COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
DOI：10.2174/1386207326666230602122618
影響因子 ：1.6
引用產(chǎn)品： U-2 OS [U2OS] 細(xì)胞 , MG-63 細(xì)胞 , Saos-2 細(xì)胞 , hFOB 1.19 細(xì)胞
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Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells (2023-09-30)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-02129-1
影響因子 ：10.2
引用產(chǎn)品： 143B 細(xì)胞 , MG-63 細(xì)胞 , Saos-2 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , 人骨髓間充質(zhì)干細(xì)胞
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Natural Chlorogenic Acid Planted Nanohybrids with Steerable Hyperthermia for Osteosarcoma Suppression and Bone Regeneration (2023-05-11)
期刊：Advanced Healthcare Materials
影響因子 ：10.0
引用產(chǎn)品： Saos-2 細(xì)胞 , MC3T3-E1 Subclone 24 細(xì)胞
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Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts (2023-02-03)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2023.01.026
影響因子 ：7.4
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , Saos-2 細(xì)胞
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Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction (2023-12-15)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1265098
影響因子 ：7.3
引用產(chǎn)品： HOS 細(xì)胞 , Saos-2 細(xì)胞
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function (2023-10-03)
期刊：EXPERT OPINION ON THERAPEUTIC TARGETS
DOI：10.1080/14728222.2023.2263908
影響因子 ：5.8
引用產(chǎn)品： U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞 , MG-63 細(xì)胞 , HOS 細(xì)胞 , SJSA-1 細(xì)胞 , hFOB 1.19 細(xì)胞 , McCoy's 5A 培養(yǎng)基 , MEM 培養(yǎng)基 , RPMI-1640 培養(yǎng)基 , DMEM/F12 培養(yǎng)基
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In vitro and in vivo killing effects of methionine enkephalin on osteosarcoma (2023-11-15)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111226
影響因子 ：5.6
引用產(chǎn)品： MG-63 細(xì)胞 , Saos-2 細(xì)胞
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ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling (2023-08-15)
期刊：American Journal of Cancer Research
DOI：PMID:37693131
影響因子 ：5.3
引用產(chǎn)品： HOS 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞 , 293T [HEK-293T] 細(xì)胞 , MG-63 細(xì)胞
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling (2023-06-15)
期刊：American Journal of Cancer Research
DOI：PMID:37424831
影響因子 ：5.3
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , HOS 細(xì)胞 , Saos-2 細(xì)胞 , MG-63 細(xì)胞
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HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway (2023-07-30)
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
DOI：10.1016/j.bbamcr.2023.119553
影響因子 ：5.1
引用產(chǎn)品： HOS 細(xì)胞 , Saos-2 細(xì)胞 , SW 1353 細(xì)胞 , McCoy's 5A 培養(yǎng)基
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RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination (2023-04-24)
期刊：CELL CYCLE
DOI：10.1080/15384101.2023.2205201
影響因子 ：4.3
引用產(chǎn)品： 293T [HEK-293T] 細(xì)胞 , hFOB 1.19 細(xì)胞 , MNNG/HOS Cl #5 [R-1059-D] 細(xì)胞 , Saos-2 細(xì)胞 , MG-63 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞
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hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression (2023-11-18)
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2023.2274120
影響因子 ：3.6
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , HOS 細(xì)胞 , Saos-2 細(xì)胞 , SW 1353 細(xì)胞 , Leibovitz's L-15 培養(yǎng)基 , McCoy's 5A完全培養(yǎng)基 (含10%FBS） , MEM 培養(yǎng)基 , DMEM/F12 培養(yǎng)基 , 青霉素-鏈霉素溶液 (雙抗)，100× , 特級胎牛血清
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy (2023-11-22)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04338-8
影響因子 ：2.6
引用產(chǎn)品： MG-63 細(xì)胞 , HOS 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞
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DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway (2023-02-27)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-03572-4
影響因子 ：2.6
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞 , MG-63 細(xì)胞
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Developing a Versatile Multiscale Therapeutic Platform for Osteosarcoma Synergistic Photothermo-Chemotherapy with Effective Osteogenicity and Antibacterial Capability (2022-09-20)
期刊：ACS Applied Materials & Interfaces
影響因子 ：10.4
引用產(chǎn)品： Saos-2 細(xì)胞 , MDA-MB-231 細(xì)胞
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Comprehensive analysis of a glycolysis and cholesterol synthesis-related genes signature for predicting prognosis and immune landscape in osteosarcoma (2022-12-23)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2022.1096009
影響因子 ：8.8
引用產(chǎn)品： MG-63 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞 , HOS 細(xì)胞 , hFOB 1.19 細(xì)胞
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CKB affects human osteosarcoma progression by regulating the p53 pathway (2022-10-15)
期刊：American Journal of Cancer Research
DOI：PMID:36381321
影響因子 ：5.9
引用產(chǎn)品： U-2 OS [U2OS] 細(xì)胞 , hFOB 1.19 細(xì)胞 , Saos-2 細(xì)胞 , HOS 細(xì)胞 , MG-63 細(xì)胞
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Integrated analysis of anti-tumor roles of BAP1 in osteosarcoma (2022-08-08)
期刊：Frontiers in Oncology
影響因子 ：5.7
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , Saos-2 細(xì)胞 , SJSA-1 細(xì)胞
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MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm (2021-03-04)
期刊：cell death and differentiation
DOI：10.1038/s41418-021-00744-9
影響因子 ：12.4
引用產(chǎn)品： Saos-2 細(xì)胞 , McCoy's 5A 培養(yǎng)基
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression (2021-08-26)
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.08.022
影響因子 ：8.8
引用產(chǎn)品： Saos-2 細(xì)胞 , MG-63 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , HOS 細(xì)胞
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Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells (2021-10-30)
期刊：Cancer Cell International
DOI：10.1186/s12935-021-02286-z
影響因子 ：5.8
引用產(chǎn)品： Saos-2 細(xì)胞
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Down-regulation of PRR11 affects the proliferation, migration and invasion of osteosarcoma by inhibiting the Wnt/β-catenin pathway (2021-09-13)
期刊：Journal of Cancer
影響因子 ：3.9
引用產(chǎn)品： Saos-2 細(xì)胞 , MG-63 細(xì)胞 , U-2 OS [U2OS] 細(xì)胞 , hFOB 1.19 細(xì)胞
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Schisandrin B Inhibits Cell Viability and Migration, and Induces Cell Apoptosis by circ_0009112/miR-708-5p Axis Through PI3K/AKT Pathway in Osteosarcoma (2021-12-22)
期刊：Frontiers in Genetics
影響因子 ：3.7
引用產(chǎn)品： U-2 OS [U2OS] 細(xì)胞 , Saos-2 細(xì)胞 , hFOB 1.19 細(xì)胞
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Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner (2021-12-20)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-021-02868-7
影響因子 ：2.6
引用產(chǎn)品： MG-63 細(xì)胞 , Saos-2 細(xì)胞
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circATP2A2 promotes osteosarcoma progression by upregulating MYH9 (2021-11-22)
期刊：Open Medicine
影響因子 ：2.1
引用產(chǎn)品： U-2 OS [U2OS] 細(xì)胞 , HOS 細(xì)胞 , Saos-2 細(xì)胞 , 特級胎牛血清 , DMEM/F12 培養(yǎng)基 , hFOB 1.19 細(xì)胞
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ADAM10 promotes cell growth, migration, and invasion in osteosarcoma via regulating E-cadherin/β-catenin signaling pathway and is regulated by miR-122-5p (2020-03-30)
期刊：Cancer Cell International
DOI：10.1186/s12935-020-01174-2
影響因子 ：5.8
引用產(chǎn)品： Saos-2 細(xì)胞 , SW 1353 細(xì)胞 , HOS 細(xì)胞 , McCoy's 5A 培養(yǎng)基
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Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells (2020-02-21)
期刊：OncoTargets and Therapy
影響因子 ：4.0
引用產(chǎn)品： Saos-2 細(xì)胞 , HOS 細(xì)胞
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Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis (2020-05-07)
期刊：OncoTargets and Therapy
影響因子 ：4.0
引用產(chǎn)品： MG-63 細(xì)胞 , Saos-2 細(xì)胞
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COLEC12 regulates apoptosis of osteosarcoma through Toll-like receptor 4–activated inflammation (2020-08-21)
期刊：JOURNAL OF CLINICAL LABORATORY ANALYSIS
影響因子 ：1.5
引用產(chǎn)品： hFOB 1.19 細(xì)胞 , MG-63 細(xì)胞 , Saos-2 細(xì)胞 , HOS 細(xì)胞
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy (2019-08-07)
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影響因子 ：5.8
引用產(chǎn)品： Saos-2 細(xì)胞 , MG-63 細(xì)胞 , HOS 細(xì)胞
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