產品中心Cell Resources
聯(lián)系我們CONTACT US
400-999-210024小時服務熱線
產品概述
產品信息
| 別名 | Interleukin-36 gamma; IL36G; IL-1-related Protein 2; IL-1RP2; IL-1 epsilon; IL-1F9; Interleukin-1 homolog 1; IL-1H1 |
| 物種 | Human |
| 表達宿主 | E.coli |
| 序列信息 | Ser18-Asp169 |
| 檢索號 | Q9NZH8 |
| 分子量 | 17.0 kDa |
| 表觀分子量 | 14-16 kDa |
| 生物活性 | Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 5-20 ng/ml. |
產品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris,100mM Nacl,0.1mM EDTA,pH8.0. |
| 復融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
Interleukin-36 gamma (IL-36γ) is a member of the Interleukin 1 Cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/ or Cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by Interleukin 1 Receptor-like 2 (IL1RL2/ IL1R-rp2), and is specifically inhibited by Interleukin 1 family, member 5 (IL1F5/ IL-1 delta). IL-36γ plays an important role in communicating the cell death to surrounding cells.
FAQs
Q：{{item.question}}
A：
暫無數據
產品資料
注：百度瀏覽器無法支持掃一掃功能，請輸入識別碼，獲取相應產品資料
識別碼示意圖
